Leptin and the Hypothalamic-Pituitary Regulation of the Gonadotropin-Gonadal Axis

Chan, Jean L.; Mantzoros, Christos S.

doi:10.1023/a:1012947113197

Cited by 124Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityReproductive Biology and Fertility

Leptin and the Hypothalamic-Pituitary Regulation of the Gonadotropin-Gonadal Axis

Chan, Jean L., Mantzoros, Christos S.·2001·Pituitary

DOI 10.1023/a:1012947113197

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Abstract

Leptin is an adipocyte-derived protein hormone which not only conveys a signal of the amount of energy stores to the central nervous system but also plays an important role in regulating neuroendocrine function. The importance of leptin in the reproductive system has been suggested by the reproductive dysfunction associated with leptin deficiency and resistance in both animal models and humans as well as the ability of leptin to accelerate the onset of reproductive function in normal mice. Transgenic mice overexpressing leptin also have accelerated puberty, and leptin administration reverses the fasting-induced suppression of sexual maturation in rodents, indicating that leptin may serve as the critical link between sufficient energy stores and proper functioning of the reproductive system. Normal women have a pulsatile release pattern of leptin that is significantly associated with the variations in luteinizing hormone (LH) and estradiol levels. In various animal models, leptin administration restores the LH pulsatility pattern which is suppressed during fasting, indicating a hypothalamic site of action since LH pulsatility is under the control of gonadotropin-releasing hormone (GnRH). In humans, leptin has been administered to a 9-year-old leptin-deficient girl, resulting in a gonadotropin secretory pattern consistent with early puberty. While in vitro experiments with hypothalamic explants and a GnRH-secreting neuronal cell line have shown that leptin can directly stimulate GnRH secretion, the lack of leptin receptors on GnRH neurons suggests that leptin may act through other hypothalamic neuropeptides. Several neuropeptides which act as downstream effectors of leptin have been investigated, and recent studies indicate that cocaine and amphetamine-regulated transcript may be such a mediator of leptin's effect on GnRH. Leptin receptors have also been identified in human pituitaries, and leptin may influence LH release from the pituitary. However, the current evidence is conflicting, and further studies are needed in order to clarify leptin's role at the level of the pituitary. Thus, accumulating evidence suggests that leptin can regulate gonadotropin levels, and its secretion may, in turn, be influenced by GnRH or gonadal steroids but appears to be independent of LH control.

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The effect of low leptin on LH pulsatility is most likely secondary to effects on the hypothalamus to influence pulsatile GnRH release.
“This effect of low leptin on LH pulsatility is most likely secondary to effects on the hypothalamus to influence pulsatile GnRH release, on the basis of in vitro and animal data (27)”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [27]

Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
Self-citation
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346 · see citing works
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
Chehab, F. F., Lim, M. E., & Lu, R. (1996) · Nature Genetics · doi:10.1038/ng0396-318 · Cited by 1,476 · see citing works
A leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158 · see citing works
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
INGALLS, A. M., DICKIE, M. M., & SNELL, G. D. (1950) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106073 · Cited by 1,090 · see citing works
Early onset of reproductive function in normal female mice treated with leptin
Chehab, F. F., Mounzih, K., Lu, R., & Lim, M. E. (1997) · Science · doi:10.1126/science.275.5296.88 · Cited by 822 · see citing works
Effects of gender, body composition, and menopause on plasma concentrations of leptin.
Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S. B., Gallagher, D., Chu, F., & Leibel, R. L. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784109 · Cited by 810 · see citing works
Effect of fasting on serum leptin in normal human subjects
Boden, G. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.9.3419 · Cited by 809 · see citing works
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 785 · see citing works
Leptin accelerates the onset of puberty in normal female mice.
Ahima, R. S., Dushay, J. R., Flier, S. N., Prabakaran, D., & Flier, J. S. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119172 · Cited by 755 · see citing works
Role of leptin in hypothalamic–pituitary function
Yu, W. H., Kimura, M., Walczewska, A., Karanth, S., & McCann, S. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.1023 · Cited by 732 · see citing works
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 731 · see citing works
Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro
Kolaczynski, J. W., Nyce, M. R., Considine, R. V., Boden, G., Nolan, J. J., Henry, R., Mudaliar, S. R., Olefsky, J., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diab.45.5.699 · Cited by 700 · see citing works
Human Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function
Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine · doi:10.1038/nm0597-575 · Cited by 632 · see citing works
Self-citation
The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence
Mantzoros, C. S. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-8-199904200-00014 · Cited by 585 · see citing works
Self-citation
Sexual Dimorphism in Plasma Leptin Concentration
Saad, M. F., Damani, S., Gingerich, R. L., Riad, M. G., Khan, A. M., Boyadjian, R., Jinagouda, S. D., El-Tawil, K., Rude, R. K., & Kamdar, V. V. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3739 · Cited by 565 · see citing works
Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
Cunningham, M. J., Clifton, D. K., & Steiner, R. A. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.216 · Cited by 531 · see citing works
Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*
Mounzih, K., Lu, R., & Chehab, F. F. (1997) · Endocrinology · doi:10.1210/en.138.3.1190 · Cited by 482 · see citing works
IRS-2 pathways integrate female reproduction and energy homeostasis
Burks, D. J., de Mora, J. F., Schubert, M., Withers, D. J., Myers, M. G., Towery, H. H., Altamuro, S. L., Flint, C. L., & White, M. F. (2000) · Nature · doi:10.1038/35030105 · Cited by 455 · see citing works
Evidence for GnRH Regulation by Leptin: Leptin Administration Prevents Reduced Pulsatile LH Secretion during Fasting
Nagatani, S., Guthikonda, P., Thompson, R. C., Tsukamura, H., Maeda, K., & Foster, D. L. (1998) · Neuroendocrinology · doi:10.1159/000054335 · Cited by 304 · see citing works
The Stimulatory Effect of Leptin on the Neuroendocrine Reproductive Axis of the Monkey 1
Finn, P. D., Cunningham, M. J., Pau, K. ‐. F., Spies, H. G., Clifton, D. K., & Steiner, R. A. (1998) · Endocrinology · doi:10.1210/endo.139.11.6297 · Cited by 294 · see citing works
Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women
Licinio, J., Negrão, A. B., Mantzoros, C., Kaklamani, V., Wong, M.-L., Bongiorno, P. B., Mulla, A., Cearnal, L., Veldhuis, J. D., Flier, J. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2541 · Cited by 287 · see citing works
Self-citation
Leptin and Leptin Receptor Expression in Rat and Mouse Pituitary Cells1
Jin, L., Zhang, S., Burguera, B. G., Couce, M., OSAMURA, R. Y., Kulig, E., & Lloyd, R. V. (2000) · Endocrinology · doi:10.1210/endo.141.1.7260 · Cited by 242 · see citing works
Leptin and Leptin Receptor Expression in Normal and Neoplastic Human Pituitary: Evidence of a Regulatory Role for Leptin on Pituitary Cell Proliferation1
Jin, L. G., Burguera, B. G., Couce, M., Scheithauer, B. W., Lamsan, J., Eberhardt, N. L., Kulig, E., & Lloyd, R. V. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5908 · Cited by 239 · see citing works
Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland
Yu, W. H., Walczewska, A., Karanth, S., & McCann, S. M. (1997) · Endocrinology · doi:10.1210/endo.138.11.5649 · Cited by 234 · see citing works
Leptin inhibits testosterone secretion from adult rat testis in vitro
Tena‐Sempere, M., Pinilla, L., Gonzalez, L., Diéguez, C., Casanueva, F. F., & Aguilar, E. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1610211 · Cited by 231 · see citing works
Leptin expression and action: New experimental paradigms
Flier, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4242 · Cited by 223 · see citing works
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
Ingalls, A. M., Dickie, M. M., & Snell, G. D. (1996) · Obesity Research · doi:10.1002/j.1550-8528.1996.tb00519.x · Cited by 191 · see citing works
Leptin activation in hypothalamus
Woods, A. J., & Stock, M. J. (1996) · Nature · doi:10.1038/381745a0 · Cited by 176 · see citing works
Leptin Regulates Pulsatile Luteinizing Hormone and Growth Hormone Secretion in the Sheep**This work was supported by a V.A. Merit Award (to C.A.J.), NIH Grants HD-18258 and HD-18394 (to D.L.F.), and Michigan Diabetes Research and Training Center Grant 2P60-DK-20572-21. A preliminary report of this work was presented at the 82nd Annual Meeting of The Endocrine Society.
Nagatani, S., Zeng, Y., Keisler, D. H., Foster, D. L., & Jaffe, C. A. (2000) · Endocrinology · doi:10.1210/endo.141.11.7762 · Cited by 158 · see citing works
Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats
Carro, E., Pinilla, L., Seoane, L. M., Considine, R. V., Aguilar, E., Casanueva, F. F., & Diéguez, C. (2008) · Neuroendocrinology · doi:10.1159/000127262 · Cited by 155 · see citing works
Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin
Yura, S., Ogawa, Y., Sagawa, N., Masuzaki, H., Itoh, H., Ebihara, K., Aizawa‐Abe, M., Fujii, S., & Nakao, K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8353 · Cited by 151 · see citing works
Chronic Administration of Leptin into the Lateral Ventricle Induces Sexual Maturation in Severely Food‐restricted Female Rats
Gruaz, N. M., Lalaoui, M., Pierroz, D. D., Englaro, P., Sizoneko, P. C., Blum, W. F., & Aubert, M. L. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00247.x · Cited by 137 · see citing works
In VitroStimulation of the Prepubertal Rat Gonadotropin-Releasing Hormone Pulse Generator by Leptin and Neuropeptide Y through Distinct Mechanisms1
Lebrethon, M. C., Vandersmissen, E., Gérard, A., Parent, A., Junien, J., & Bourguignon, J.-P. (2000) · Endocrinology · doi:10.1210/endo.141.4.7432 · Cited by 137 · see citing works
ACTH- and α-MSH-induced grooming, stretching, yawning and penile erection in male rats: Site of action in the brain and role of melanocortin receptors
Argiolas, A., Melis, M. R., Murgia, S., & Schiöth, H. B. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00270-1 · Cited by 132 · see citing works
Expression of a Leptin Receptor in Immortalized Gonadotropin-Releasing Hormone-Secreting Neurons
Magni, P., Vettor, R., Pagano, C., Calcagno, A., Beretta, E., Messi, E., ZANISI, M., Martini, L., & Motta, M. (1999) · Endocrinology · doi:10.1210/endo.140.4.6622 · Cited by 132 · see citing works
Localization of Leptin Receptor-Like Immunoreactivity in the Corticotropes, Somatotropes, and Gonadotropes in the Ovine Anterior Pituitary1
Iqbal, J., Pompolo, S., Considine, R. V., & Clarke, I. J. (2000) · Endocrinology · doi:10.1210/endo.141.4.7433 · Cited by 120 · see citing works
Abnormal regulation of the leptin gene in the pathogenesis of obesity.
Ioffe, E., Moon, B., Connolly, E., & Friedman, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11852 · Cited by 117 · see citing works
Leptin116–130 Stimulates Prolactin and Luteinizing Hormone Secretion in Fasted Adult Male Rats
González, L. C., Pinilla, L., Tena‐Sempere, M., & Aguilar, E. (1999) · Neuroendocrinology · doi:10.1159/000054479 · Cited by 109 · see citing works
Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y
Parent, A., Lebrethon, M. C., Gérard, A., Vandersmissen, E., & Bourguignon, J. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00144-0 · Cited by 107 · see citing works
A Reproductive Endocrine Profile in the Diabetes (db) Mutant Mouse1
Johnson, L. M., & Sidman, R. L. (1979) · Biology of Reproduction · doi:10.1095/biolreprod20.3.552 · Cited by 107 · see citing works
Endocrine function of neuropeptide Y knockout mice
Erickson, J. C., Ahima, R. S., Hollopeter, G., Flier, J. S., & Palmiter, R. D. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01007-0 · Cited by 96 · see citing works
Intact Leptin Receptor Is Selectively Expressed in Human Fetal Pituitary and Pituitary Adenomas and Signals Human Fetal Pituitary Growth Hormone Secretion1
Shimon, I., Yan, X., Magoffin, D. A., Friedman, T. C., & Melmed, S. K. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.11.5273 · Cited by 95 · see citing works
Leptin as a regulator of adipose mass and reproduction
Chehab, F. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01514-5 · Cited by 92 · see citing works
Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction
Hohmann, J. G., Teal, T. H., Clifton, D. K., Davis, J., Hruby, V. J., Han, G., & Steiner, R. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.1.r50 · Cited by 91 · see citing works
Cocaine and Amphetamine‐Regulated‐Transcript Peptide Mediation of Leptin Stimulatory Effect on the Rat Gonadotropin‐Releasing Hormone Pulse Generator In Vitro
Lebrethon, Vandersmissen, Gérard, Parent, & Bourguignon (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00497.x · Cited by 89 · see citing works
Normal Reproductive Function in Leptin-Deficient Patients with Lipoatropic Diabetes
Andréelli, F., Hanaire, H. P., Laville, M., Tauber, J.-P., Riou, J. P., & Thivolet, C. H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.2.6392 · Cited by 72 · see citing works
Reproductive Function in the Genetically Obese “Fatty” Rat
Saiduddin, S., Bray, G. A., York, D. A., & SWERDLOFFf, R. S. (1973) · Endocrinology · doi:10.1210/endo-93-6-1251 · Cited by 65 · see citing works
A Significant Role of Leptin in the Generation of Steroid-Induced Luteinizing Hormone and Prolactin Surges in Female Rats
Kohsaka, A., Watanobe, H., Kakizaki, Y., Habu, S., & Suda, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.0112 · Cited by 50 · see citing works
Subcellular Localization of Leptin in Non-tumorous and Adenomatous Human Pituitaries: An Immuno-ultrastructural Study
Vidal, S., Cohen, S. M., Horváth, É., Kovács, K., Scheithauer, B. W., Burguera, B. G., & Lloyd, R. V. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800811 · Cited by 45 · see citing works
Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma
Dieterich, K., & Lehnert, H. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1212027 · Cited by 40 · see citing works
Leptin acts centrally to induce the prepubertal secretion of luteinizing hormone in the female rat☆
Dearth, R. K., Hiney, J. K., & Dees, W. L. (2000) · Peptides · doi:10.1016/s0196-9781(00)00157-1 · Cited by 37 · see citing works
Episodic leptin release is independent of luteinizing hormone secretion
Sir‐Petermann, T., Maliqueo, M. A., Palomino, A., Vantman, D., Recabarren, S. E., & Wildt, L. (1999) · Human Reproduction · doi:10.1093/humrep/14.11.2695 · Cited by 21 · see citing works
Effect of acute immunoneutralization of endogenous leptin on prolactin and LH secretion during the afternoon of pro-oestrus or in steroid-treated ovariectomized female rats
Gonzalez, L., Pinilla, L., Tena‐Sempere, M., Diéguez, C., Casanueva, F. F., & Aguilar, E. (2000) · Reproduction · doi:10.1530/jrf.0.1180039 · Cited by 15 · see citing works
Effect of acute immunoneutralization of endogenous leptin on prolactin and LH secretion during the afternoon of pro-oestrus or in steroid-treated ovariectomized female rats
Gonzalez, L., Pinilla, L., Tena‐Sempere, M., et al. (2000) · Reproduction · doi:10.1530/reprod/118.1.39 · Cited by 11 · see citing works

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Kahn, C. R., Wang, G., & Lee, K. Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129187 · Cited by 656 · see citing works
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Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works
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Donato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J. L., de Castro, I. A., Margatho, L. O., Lee, S., Lee, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45106 · Cited by 356 · see citing works
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Marino, M., Masella, R., Bulzomi, P., Campesi, I., Malorni, W., & Franconi, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.02.001 · Cited by 152 · see citing works
Role of leptin in female reproduction
Pérez‐Pérez, A., Sánchez-Jiménez, F., Maymó, J. L., Dueñas, J. L., Varone, C. L., & Sánchez‐Margalet, V. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-0387 · Cited by 154 · see citing works
Roles of ghrelin and leptin in the control of reproductive function
Tena-Sempere, M. (2007) · Neuroendocrinology · doi:10.1159/000108410 · Cited by 141 · see citing works
Amino Acid-Dependent Activation of Liver Estrogen Receptor Alpha Integrates Metabolic and Reproductive Functions via IGF-1
Torre, S. D., Rando, G., Meda, C., Stell, A., Chambon, P., Krust, A., Ibarra, C., Magni, P., Ciana, P., & Maggi, A. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.002 · Cited by 134 · see citing works
Metformin Therapy during Puberty Delays Menarche, Prolongs Pubertal Growth, and Augments Adult Height: A Randomized Study in Low-Birth-Weight Girls with Early-Normal Onset of Puberty
Ibáñez, L., Valls, C., Ong, K. K., Dunger, D. B., & de Zegher, F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2329 · Cited by 130 · see citing works
Caloric restriction: Impact upon pituitary function and reproduction
Martin, B., Golden, E. J., Carlson, O. D., Egan, J. M., Mattson, M. P., & Maudsley, S. R. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.01.002 · Cited by 93 · see citing works
Adipose tissue and reproduction in women
BOHLER, H. C. L., Mokshagundam, S. L., & Winters, S. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.079 · Cited by 94 · see citing works
Landmarks in the development of the female reproductive system
Beckman, D. A., & Feuston, M. H. (2003) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.10016 · Cited by 76 · see citing works
Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence
Odle, A. K., Akhter, N., Syed, M., Allensworth‐James, M. L., Beneš, H., Castillo, A. I. M., MacNicol, M. C., MacNicol, A. M., & Childs, G. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00367 · Cited by 77 · see citing works
Leptin in congenital and HIV-associated lipodystrophy
Tsoukas, M. A., Farr, O. M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.017 · Cited by 58 · see citing works
Self-citation
Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health
Stefanakis, K., Upadhyay, J., Ramirez-Cisneros, A., Patel, N., Sahai, A., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156056 · Cited by 63 · see citing works
Self-citation
Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility
Akhter, N., CarlLee, T. L., Syed, M., Odle, A. K., Cozart, M. A., Haney, A. C., Allensworth‐James, M. L., Beneš, H., & Childs, G. V. (2014) · Endocrinology · doi:10.1210/en.2014-1132 · Cited by 44 · see citing works
Evidence from clinical studies of leptin: current and future clinical applications in humans
Perakakis, N., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156053 · Cited by 48 · see citing works
Self-citation
Ecological and reproductive variance in serum leptin in wild vervet monkeys
Whitten, P. L., & Turner, T. R. (2008) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20885 · Cited by 40 · see citing works
Leptin-Mediated Neuroendocrine Alterations in Anorexia Nervosa: Somatic and Behavioral Implications
Müller, T. D., Föcker, M., Holtkamp, K., Herpertz‐Dahlmann, B., & Hebebrand, J. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2008.07.002 · Cited by 40 · see citing works
The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review
Zamanian, M. Y., Bazmandegan, G., Sureda, A., Sobarzo‐Sánchez, E., Yousefi‐Manesh, H., & Shirooie, S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200510020744 · Cited by 35 · see citing works
The Estrogenic Inhibition of Eating
Geary, N. (2004) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48643-1_12 · Cited by 40 · see citing works
Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty
Lee, H. S., Yoon, J. S., & Hwang, J. S. (2016) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.3091 · Cited by 31 · see citing works
Distribution of the neuronal inputs to the ventral premammillary nucleus of male and female rats
Cavalcante, J. C., Bittencourt, J. C., & Elias, C. F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.034 · Cited by 29 · see citing works
Central causes of hypogonadism—functional and organic
Warren, M. P., & Vu, C. Q. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00042-2 · Cited by 28 · see citing works
Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide
Babaei, M., Alizadeh‐Fanalou, S., Nourian, A., Yarahmadi, S., Farahmandian, N., Nabi‐Afjadi, M., Alipourfard, I., & Bahreini, E. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00794-1 · Cited by 26 · see citing works
Acylated and unacylated ghrelin levels in normal weight and obese children: influence of puberty and relationship with insulin, leptin and adiponectin levels.
Bellone, S., Prodam, F., Savastio, S., Rienzo, F. D., Demarchi, I., Trovato, L., Petri, A., Rapa, A., Aimaretti, G., & Bona, G. (2012) · PubMed · doi:10.3275/7761 · Cited by 27 · see citing works
PI 3K signalling in leptin receptor cells: Role in growth and reproduction
García-Galiano, D., Borges, B. C., Allen, S. J., & Elias, C. F. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12685 · Cited by 24 · see citing works
A study of depression and anxiety in cancer patients.
Thapa, P., Rawal, N. M., & Bista, Y. (2010) · PubMed · Cited by 24 · see citing works
Food Safety and Functional Foods in the European Union: Obesity as a Paradigmatic Example for Novel Food Development
Palou, A., Picó, C., & Bonet, M. L. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00089.x · Cited by 24 · see citing works
Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
Mantzoros, C. S. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.3.181 · Cited by 22 · see citing works
Self-citation
Co‐Expression of Leptin and Oestrogen Receptors in the Preoptic‐Hypothalamic Area
Borges, B. D. B., Cabral, F. J., & Franci, C. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02046.x · Cited by 20 · see citing works
The effect of cumulative endurance exercise on leptin and adiponectin and their role as markers to monitor training load.
Voss, S. C., Николовски, З., Bourdon, P. C., Alsayrafi, M., & Schumacher, Y. O. (2016) · Europe PMC (PubMed Central) · doi:10.5604/20831862.1180173 · Cited by 20 · see citing works
Inhibin B: A Potential Marker of Gonadal Activity in Patients with Anorexia Nervosa during Weight Recovery
POPOVIC, V. M., Djurovic, M. N., Ćetković, A., Vojvodić, D., Pekić, S., Spremović-Radjenović, S., Petakov, M. S., Damjanovic, S. S., Milic, N. M., Diéguez, C., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031326 · Cited by 20 · see citing works
Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state
Allen, S. J., García-Galiano, D., Borges, B. C., Burger, L. L., Boehm, U., & Elias, C. F. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00529.2015 · Cited by 18 · see citing works
Age at menarche of subpopulation of Nepalese girls.
Sunuwar, L., Saha, C. G., Anupa, K. C., & Dhungel, K. U. (2010) · PubMed · Cited by 18 · see citing works
Leptina: aspectos sobre o balanço energético, exercício físico e amenorréia do esforço
Ribeiro, S. M. L., dos Santos, Z. A., da Silva, R. J., Eliana, L. R., Donato, J., & Tirapegui, J. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000100005 · Cited by 18 · see citing works
Rescue effect of sodium acetate in diabetes mellitus-associated testicular dysfunction is accompanied by PCSK9 modulation
Olaniyi, K. S., Badejogbin, O. C., Saliu, S. B., & Olatunji, L. A. (2021) · Biochimie · doi:10.1016/j.biochi.2021.02.004 · Cited by 16 · see citing works
Garden Cress Seed Oil Abrogates Testicular Oxidative Injury and NF-kB-Mediated Inflammation in Diabetic Mice
Abu‐Khudir, R., Badr, G. M., El‐Moaty, H. I. A., Hamad, R. S., Abdulsalam, N. K. A., Abdelrahem, A. S. A., Alqarni, S., Alkuwayti, M. A., Salam, S. A., & El-Kareem, H. F. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015478 · Cited by 14 · see citing works
Leptin Stimulates LH Secretion in Peripubertal Male Rats Through NMDA Receptors
Carbone, S., Szwarcfarb, B., Reynoso, R., Bollero, G., Ponzo, O., Rondina, D., Scacchi, P. A., & Moguilevsky, J. A. (2005) · Endocrine Research · doi:10.1080/07435800500458032 · Cited by 13 · see citing works
Brain–Bone Axis in Physiological and Pathological Conditions
Massaccesi, L., Romanelli, M. M. C., & Galliera, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199822 · Cited by 12 · see citing works
Melatonin Administration Accelerates Puberty Onset in Mice by Promoting FSH Synthesis
Yang, C., Ran, Z., Liu, G., Hou, R., He, C., Liu, Q., Chen, Y., Liu, Y., Wang, X., Ling, C., et al. (2021) · Molecules · doi:10.3390/molecules26051474 · Cited by 12 · see citing works
The relationship between the levels of gonadotropic hormones and OPG, leptin, TGF-β1 and TGF-β2 in Chinese adult women
Wu, X., Wu, X.-P., Luo, X., Xie, H., Zhang, H., Peng, Y., Yuan, L., Jiang, Y., & Liao, E.-Y. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.05.006 · Cited by 12 · see citing works
Savanna Monkeys
Turner, T. R., Schmitt, C. A., & Cramer, J. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941 · Cited by 17 · see citing works
The effects of physical exercise therapy on weight control: its regulation of adipocyte physiology and metabolic capacity
Park, H.-J., Rhie, S. J., & Shim, I. (2023) · Journal of Exercise Rehabilitation · doi:10.12965/jer.2346232.116 · Cited by 11 · see citing works
Pituitary Leptin-A Paracrine Regulator of Gonadotropes: A Review
Akhter, N. (2011) · The Open Neuroendocrinology Journal · doi:10.2174/1876528901104010025 · Cited by 10 · see citing works
Effects of leptin on FSH cells in the pituitary gland of Podarcis siculus
Ferrandino, I., Monaco, A., & Grimaldi, M. C. (2015) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2014.12.006 · Cited by 10 · see citing works
Leptin: From Satiety Signal to Reproductive Regulator
Henson, M. C., Castracane, V. D., & Edwards, D. E. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0157-2_1 · Cited by 10 · see citing works
Dissociable effects of hunger, exposure and sensory overlap on flavour liking
Khorisantono, P. A., Fondberg, R., Achs, L., Friedrich, N. N., Harenbrock, J., Hog, L., Persson, J., Weber, M.-C., Lundström, J. N., & Seubert, J. (2024) · Food Quality and Preference · doi:10.1016/j.foodqual.2024.105211 · Cited by 9 · see citing works
Savanna Monkeys: The Genus Chlorocebus
Turner, T. R., Schmitt, C. A., & Cramer, J. D. (2019) · Cited by 8 · see citing works
Leptin-like immunoreactivity in the central nervous system, digestive organs, and gonads of the giant freshwater prawn, Macrobrachium rosenbergii
Poljaroen, J., Tinikul, Y., Tinikul, R., Anurucpreeda, P., & Sobhon, P. (2017) · Acta Histochemica · doi:10.1016/j.acthis.2017.06.001 · Cited by 6 · see citing works
Hyperandrogenemia elevates expression of apelin and apelin receptor protein in the mice pituitary
Riba, P., Anima, B., Dutta, A., Gurusubramanian, G., & Roy, V. K. (2024) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2857 · Cited by 5 · see citing works
Clomiphene Citrate in the Management of Infertility in Oligospermic Obese Men with Hypogonadism: Retrospective Pilot Study
Selvam, M. K. P., Baskaran, S., Tannenbaum, J., Greenberg, J. W., Shalaby, H., Hellstrom, W. J. G., & Sikka, S. C. (2023) · Medicina · doi:10.3390/medicina59111902 · Cited by 5 · see citing works
Diurnal Leptin Secretion Is Intact in Male Hypogonadotropic Hypogonadism and Is Not Influenced by Exogenous Gonadotropins
Kılcıler, G., Özata, M., Öktenli, Ç., Sanisoğlu, S. Y., Bolu, E., Bingöl, N., Kilciler, M., Ozdemír, I. C., & Kutlu, M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020516 · Cited by 5 · see citing works
The Social and Thermal Competence of Wild Vervet Monkeys
McFarland, R., Henzi, S. P., & Barrett, L. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.015 · Cited by 5 · see citing works
Hormones and Reproductive Cycles in Rodents
Bales, K. L., & Hostetler, C. M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374928-4.10011-2 · Cited by 5 · see citing works
Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty
Liang, Y., Yuan, Y., & Yang, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1448111 · Cited by 4 · see citing works
Altered production of reproductive neuropeptides in rats subjected to chronic intermittent hypoxia
Terrizzi, A. R., Martínez, M. P., & Fernández‐Solari, J. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2003069 · Cited by 4 · see citing works
AGE AT MENARCHE AND BODY MASS INDEX AMONG SCHOOL GOING ADOLESCENT GIRLS IN BHARATPUR METROPOLITAN CITY CHITWAN
Bhusal, P., Khatiwada, S., & Poudyel, P. (2022) · Journal of Chitwan Medical College · doi:10.54530/jcmc.567 · Cited by 4 · see citing works
Neuroendokrine Regulation der Ovarialfunktion
Wildt, L., & LEYENDECKER, G. (2011) · Springer eBooks · doi:10.1007/978-3-642-15012-8_29 · Cited by 4 · see citing works
Savanna Monkey Taxonomy
Turner, T. R., Schmitt, C. A., & Cramer, J. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.003 · Cited by 4 · see citing works
Behavioral Ecology of Savanna Monkeys
Turner, T. R., Schmitt, C. A., & Cramer, J. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.009 · Cited by 3 · see citing works
TRANSFERENCIA EMBRIONARIA IPSILATERAL Y CONTRALATERAL A LA POSICIÓN DEL CUERPO LÚTEO Y SUPERVIVENCIA EMBRIONARIA EN LLAMAS.
Salazar, S. C., Wilfredo Huanca, L., Aída Cordero, R., Martha Vásquez, E., & Teodosio Huanca, M. (2011) · Revista de Investigaciones Veterinarias del Perú · doi:10.15381/rivep.v22i2.278 · Cited by 3 · see citing works
Anorexia Nervosa and Bulimia Nervosa
Paz-Filho, G., & Licinio, J. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00093-0 · Cited by 3 · see citing works
Nutrition and Reproduction
Santoro, N. F., Polotsky, A. J., Rieder, J., & Kondapalli, L. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00018-4 · Cited by 3 · see citing works
Estradiol and the feeding state modulate the interaction between leptin and the nitrergic system in female rats
Oliveira, L. L. B., Borges, B. D. B., & Franci, C. R. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102096 · Cited by 2 · see citing works
Leptin: A Metabolic Signal for the Differentiation of Pituitary Cells
Childs, G. V., Odle, A. K., MacNicol, M. C., Allensworth‐James, M. L., Miles, T. K., Akhter, N., Syed, M., & MacNicol, A. M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100922 · Cited by 2 · see citing works
Obesity-related metabolic and reproductive dysfunction: variations between the sexes
Dimitriadis, G. K., & Barber, T. M. (2016) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2016.1220301 · Cited by 2 · see citing works
Juvenile Animal Studies and Experience
Martin, P. L., & Coogan, T. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417144-2.00026-3 · Cited by 2 · see citing works
Hormones and Reproductive Cycles in Rodents
Bales, K. L., & Hostetler, C. M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374932-1.00058-5 · Cited by 2 · see citing works
Hormones and reproductive cycles in rodents
Lee, N. S., & Beery, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15986-2.00009-5 · Cited by 2 · see citing works
Biological Resources for Genomic Investigation in the Vervet Monkey (Chlorocebus)
Jasinska, A. J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.002 · Cited by 2 · see citing works
Nuclear Factor Kappa-B Protein Levels in Sperm of Obese Men with and without Diabetes; Cellular Approach in Male Infertility.
Abbasihormozi, S., Kouhkan, A., Shaverdi, A., Gilani, M. A. S., Babapour, V., Naslji, A. N., Akbarinehad, V., & Alizadeh, A. (2023) · PubMed Central · doi:10.22074/cellj.2022.557547.1065 · Cited by 1 · see citing works
Circadian rhythm disruption induces PCOS-like phenotypes by interfering with ovarian steroid hormone synthesis pathways
Feng, C., Guo, L., Xin, G. A. O., Ji, X., Liu, Y., Liu, J., Liu, S., Liu, Y., Ma, L., & He, X. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106980 · Cited by 1 · see citing works
Pulsatile GnRH-Therapie
Wildt, L., & LEYENDECKER, G. (2013) · Springer eBooks · doi:10.1007/978-3-642-30181-0_12 · Cited by 1 · see citing works
Eating and Feeding Disorders
Misra, M., & Eddy, K. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00084-5 · Cited by 1 · see citing works
Life History of Savanna Monkeys
Turner, T. R., Schmitt, C. A., & Cramer, J. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.014 · Cited by 1 · see citing works
The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
Bilgin, R. B. G., Özen, S., Gökşen, D., Korkmaz, Ö., & Darcan, Ş. (2021) · The Journal of Pediatric Research · doi:10.4274/jpr.galenos.2021.67689 · Cited by 1 · see citing works
A diabetic patient at the urological clinic
Piťhová, P. (2021) · Urologie pro praxi · doi:10.36290/uro.2021.032 · Cited by 1 · see citing works
Pulsatile GnRH-Therapie
Wildt, L., Böttcher, B., & LEYENDECKER, G. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-57636-6_16 · Cited by 1 · see citing works
Leptin and IGF-1 in Infancy Are Associated With Variants in DHCR7 and CYP2R1 That Relate With Type 1 Diabetes and 25OHD
Eleftheriou, A., Ong, K. K., Hughes, I. A., & Petry, C. J. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad263 · Cited by 1 · see citing works
Ethnoprimatology and Savanna Monkeys
Turner, T. R., Schmitt, C. A., & Cramer, J. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.019 · Cited by 1 · see citing works
Pulsatile GnRH-Therapie
Wildt, L., Böttcher, B., & LEYENDECKER, G. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-55601-6_16-1 · Cited by 1 · see citing works
Control of reproductive function
WEBB, R. (2012) · ERA · Cited by 1 · see citing works
Estudo da ação do núcleo pré-mamilar ventral de ratos no controle reprodutivo e em respostas à exposição feromonal.
Donato, J. (2008) · doi:10.11606/t.42.2008.tde-12032009-181647
Effect of rams on temporal hormone concentrations in Targhee ewes during the transition into the breeding season
McCosh, R. B. (2011) · Montana State University ScholarWorks (Montana State University)
Leptin expression in embryos sired by male golden hamsters (mesocricetus auratus) with all accessory sex glands removed
Liao, S.-B. (2007) · doi:10.5353/th_b3963403
Food Safety and Functional Foods in the European Union: Obesity as a Paradigmatic Example for Novel Food
Picó, C., & Bonet, M. L. (2004)
The Vervet Microbiome
Amato, K. R. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.006
Measurement of Novelty-Seeking in Wild Vervet Monkeys
Blaszczyk, M. B. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.017
Population Genetic Structure of Vervet Monkeys in South Africa
Coetzer, W. G., Lorenz, J. G., Freimer, N. B., & Grobler, J. P. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139019941.008

Authors: Chan, J. L., & Mantzoros, C. S.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Chan, Jean L.
ORCID: Mantzoros, Christos S.
Venue: Pituitary
Publisher: Springer Science and Business Media LLC
Published: 2001-01
Volume: 4
Issue: 1-2
Pages: 87-92
ISSN: 1386-341X (ISSN-L)
1573-7403
DOI: 10.1023/a:1012947113197
OpenAlex: W9174261
Cited by: 124
References: 60
Citations by year: 2026: 6 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 30 · 2018: 3 · 2017: 1 · 2016: 7 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 3
FWCI: 2.86
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Pituitary (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: leptin, hypothalamic-pituitary-gonadal axis, gonadotropin-releasing hormone, luteinizing hormone, GnRH neurons, leptin receptor, neuropeptides, CART, puberty, energy homeostasis, leptin resistance, estradiol, gonadotropin secretion
MeSH terms: Animals, Gonadotropins, Gonads, Humans, Hypothalamo-Hypophyseal System, Reproduction, Leptin

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Leptin and the Hypothalamic-Pituitary Regulation of the Gonadotropin-Gonadal Axis

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About these checks