Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

Mounzih, Khalid; Lu, Ronghua; Chehab, Farid F.

doi:10.1210/en.138.3.1190

Cited by 482Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesitySperm and Testicular Function

Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

Mounzih, Khalid, Lu, Ronghua, Chehab, Farid F.·1997·Endocrinology

DOI 10.1210/en.138.3.1190

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Abstract

Leptin, a hormone secreted from white adipose tissue, has been shown to normalize the body weight of ob/ob but not db/db mice as postulated by Coleman in his classical parabiosis experiments. The major effect of leptin is therefore to decrease food intake, thus resulting in a breakdown of fat stores. Recently, we have suggested that leptin plays a role in reproductive physiology based on the observation that leptin treatment but not food restriction rescues the sterility of ob/ob females. In the present communication, we treated sterile ob/ob males with leptin and asked whether fertility could be induced, thus selecting their reproductive ability as the endpoint of the experiment. Our results show that all food-restricted ob/ob males are unable to impregnate normal C57BL/6J females. However, all leptin-treated ob/ob males fertilized normal females mice that carried out normal pregnancies and deliveries, demonstrating that the reproductive capacity of ob/ob males was corrected only with leptin treatment. Furthermore, reproductive indices such as testicular weight and histology are normalized in leptin-treated animals. Therefore, as in ob/ob females, leptin plays a significant role in the male mouse reproductive pathways.

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Exogenous leptin corrects the sterility of leptin-deficient ob/ob mice.
“and corrects the sterility of leptin-deficient ob/ob mice (29, 30).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [30]

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Authors: Mounzih, K., Lu, R., & Chehab, F. F.
Affiliations: University of California, San Francisco (US)
ORCID: Lu, Ronghua
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1997-03-01
Volume: 138
Issue: 3
Pages: 1190-1193
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.138.3.1190
OpenAlex: W1997157145
Cited by: 482
References: 26
Citations by year: 2026: 3 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 21 · 2017: 19 · 2016: 17 · 2015: 11 · 2014: 20 · 2013: 24 · 2012: 20
FWCI: 26.15
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: University of California, San Francisco
National Heart, Lung, and Blood Institute (HLS-53762)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: leptin, ob/ob mice, male infertility, reproductive capacity, dietary restriction, testicular histology, testicular weight, obesity, reproductive physiology
MeSH terms: Animals, Body Weight, Eating, Female, Fertility, Infertility, Male, Obesity, Organ Size, Proteins, Testis, Leptin, Mice

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Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

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