Familial risk among patients with endometriosis
Open accessAbstract
Purpose The objective of the present study was to determine the prevalence of endometriosis among the relatives of patients with confirmed endometriosis.Methods We analyzed the prevalence of endometriosis among first-, second-, and third-degree relatives in a group of 101 patients with varying symptoms related to endometriosis seen at two public hospitals and submitted to laparoscopy and/or laparotomy. The control group consisted of 43 women submitted to laparoscopy without a diagnosis of endometriosis.Results Among the patients with endometriosis, we detected nine families with a positive history of endometriosis, comprising one mother, six sisters, three aunts, and two cousins, as opposed to no case among the controls.Conclusions These data confirm a familial tendency for endometriosis and suggest that this disorder has a genetic basis.
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The self-reported family history rate in this sample (40%) is higher than rates reported in studies from Puerto Rico (20%), Brazil (8.9%), Japan (8.8%), and the US (8.1%).
“This rate of family history is higher than what has been reported in other published studies of patients from Puerto Rico (20%) (31), Brazil (8.9%) (32), Japan (8.8%) (33), and the US (8.1%) (34).”
From Patients’ report on how endometriosis affects health, work, and daily life (2010) · cites this paper as [32]
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- Authors
- Dos Reis, R. M., Silva De Sá, M. F., De Moura, M. D., Nogueira, A. A., Ribeiro, J. U., Ramos, E. S., & Ferriani, R. A.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal do Triângulo Mineiro (BR)
- Venue
- Journal of Assisted Reproduction and Genetics
- Published
- 1999-10
- Volume
- 16
- Issue
- 9
- Pages
- 500-503
- ISSN
- 0740-7769 (ISSN-L)
- 1058-0468
- 1573-7330
- PMC
- PMC3455623
- OpenAlex
- W1578274906
- Cited by
- 48
- References
- 10
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2017: 1 · 2015: 6 · 2013: 3 · 2012: 2
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Assisted Reproduction and Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, familial risk, genetic susceptibility, genetic basis, first-degree relatives, sisters, family history (medicine)
- MeSH terms
- Adult, Endometriosis, Female, Humans, Middle Aged, Pedigree, Prevalence, Risk Assessment
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