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Cited by 248Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

The familial risk of endometriosis

Moen, Mette H., Magnus, Per·1993·Acta Obstetricia Et Gynecologica Scandinavica
DOI 10.3109/00016349309058164
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Abstract

OBJECTIVE: To study the occurrence of endometriosis or adenomyosis in mothers and sisters of patients with endometriosis. METHODS: A total of 563 patients with endometriosis were interviewed about endometriosis or adenomyosis in their mothers or sisters. Five hundred and twenty-eight patients (94%) gave information about their relatives. Six patients were adopted and had no knowledge about their relatives. Among 522 patients were seven pairs of sisters, of which only one was included, giving a total of 515 cases. The control group consisted of 149 women without endometriosis documented at a recently diagnostic laparoscopy performed in connection with sterilization. The controls were likewise interviewed about their relatives, and none refused to give information. If a gynecological operation in a relative was reported, medical records were obtained (68%) or a description of the medical history was given by the proband. RESULTS: Endometriosis or adenomyosis was disclosed in 3.9% of mothers of cases and in 0.7% of mothers of controls, in 4.8% of sisters of cases and in 0.6% of sisters of controls. The relative risk of endometriosis in a first-degree relative (expressed as odds ratio), was 7.2 (95% confidence interval 2.1, 24.3). Severe manifestations of endometriosis were found more often among patients with a positive family history than among those without (26% versus 12%, p < 0.01). CONCLUSION: The study demonstrates a seven fold increased risk of endometriosis in mothers and sisters of patients with endometriosis. It is assumed that daughters of patients with endometriosis have a similar risk of developing endometriosis.

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  • In twin sisters, prevalence of endometriosis and age of onset are similar.

    “In twin sisters a prevalence of endometriosis (158-161) and age of onset (162) are similar.”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [159]

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Authors
Moen, M. H., & Magnus, P.
Affiliations
  • University of Oslo (NO)
  • Norwegian Institute of Public Health (NO)
Corresponding author
Moen, Mette H.
ORCID
Venue
Acta Obstetricia Et Gynecologica Scandinavica
Publisher
Wiley
Published
1993-10
Volume
72
Issue
7
Pages
560-564
ISSN
  • 0001-6349 (ISSN-L)
  • 1600-0412
DOI
10.3109/00016349309058164
OpenAlex
W1972563403
Cited by
248
References
14
Citations by year
2026: 3 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 1 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 4
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6307 d)
Locations
  • Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, adenomyosis, familial risk, family history (medicine), first-degree relatives, genetic susceptibility, endometriosis severity
MeSH terms
Adult, Endometriosis, Female, Humans, Norway, Risk Factors, Case-Control Studies

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