Familial endometriosis
Abstract
Purpose The study aimed to identify families with endometriosis and to document disease severity within the families and the clinical characteristics of the affected women.Results Two hundred and thirty women with surgically confirmed endometriosis in 100 families were identified. The families consisted of 19 mother-daughter pairs, 1 set of cousins and 56 sister pairs. There were 5 families with 3 affected sisters, 1 family with 5 affected sisters, and 18 families with > or = 3 affected members in more than one generation. The mean age at the onset of symptoms and the mean age at surgical diagnosis was 22.1 +/- 8.8 SD (range 10-46) and 31.8 +/- 7.9 SD (range 15-56) years respectively. Seventy-nine women (34.3%) had revised AFS Stage I-II disease, and 151 (65.7%) had revised AFS Stage III-IV disease.Conclusion The study confirms a familial tendency for endometriosis and supports the hypothesis that endometriosis has a genetic basis.
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Familial clustering of endometriosis is well established in humans and primates.
“Well established are familial clustering in humans (156) and primates (157).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [156]
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- Authors
- Kennedy, S., Mardon, H., & Barlow, D.
- Affiliations
- John Radcliffe Hospital (GB)
- ORCID
- Kennedy, Stephen
- Venue
- Journal of Assisted Reproduction and Genetics
- Published
- 1995-01
- Volume
- 12
- Issue
- 1
- Pages
- 32-34
- ISSN
- 0740-7769 (ISSN-L)
- 1058-0468
- 1573-7330
- OpenAlex
- W4248912009
- Cited by
- 157
- References
- 8
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Assisted Reproduction and Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, disease severity, age at symptom onset, mother-daughter pairs, sisters, multigenerational families
- MeSH terms
- Australia, Endometriosis, Europe, Female, Humans, Hysterectomy, Laparotomy, New Zealand, North America, Pedigree, Laparoscopy, Severity of Illness Index, Prevalence
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