Differentiation and death of premyelinating oligodendrocytes in developing rodent brain
Open accessAbstract
Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. This study has characterized the appearance and fate of newly formed oligodendrocytes in developing rat brain. Oligodendrocytes appear in predictable locations and radially extend DM-20-positive processes that cover 80-microm domains in the cortex and 40-microm domains in the corpus callosum. These premyelinating oligodendrocytes have one of two fates: they myelinate axons or degenerate. Between 7 and 21 d after birth, approximately 20% of premyelinating oligodendrocytes identified in the cerebral cortex were degenerating. Oligodendrocytes that ensheathed axons expressed and selectively targeted proteolipid protein to compact myelin and did not degenerate. These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products.
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In the developing neocortex, approximately 20% of premyelinating OLs die between P7 and P11.
“In the developing neocortex, ∼20% of premyelinating OLs die between P7 and P11 (Trapp et al., 1997).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Trapp et al., 1997
The Results section reports that approximately 20% of premyelinating oligodendrocytes in the developing cerebral cortex were degenerating at observations between P7 and P21. It does not establish that 20% died specifically between P7 and P11; the Discussion says the incidence of death cannot be determined without knowing how long degeneration remains detectable. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe appearance of PAM coincides with the onset of myelination, when many newly formed oligodendrocytes die.
“The timing of their appearance coincides with the onset of myelination, during which large numbers of newly formed oligodendrocytes die (Barres et al., 1992; Trapp et al., 1997).”
From Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing (2019) · cites this paper as Trapp et al., 1997
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- Authors
- Trapp, B. D., Nishiyama, A., Cheng, D., & Macklin, W.
- Affiliations
- Cleveland Clinic (US)
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1997-04-21
- Volume
- 137
- Issue
- 2
- Pages
- 459-468
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2139778
- OpenAlex
- W2097849969
- Cited by
- 395
- References
- 41
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 16 · 2022: 14 · 2021: 23 · 2020: 26 · 2019: 16 · 2018: 13 · 2017: 15 · 2016: 12 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 7
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS25304, R01NS029818, R01NS025304, NS 29818)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- oligodendrocyte differentiation, oligodendrocyte death, myelination, proteolipid protein, DM20, oligodendrocyte survival, cerebral cortex, corpus callosum, postnatal brain development
- MeSH terms
- Animals, Axons, Brain, Cell Differentiation, Cerebral Cortex, Chromatin, Corpus Callosum, Nerve Tissue Proteins, Oligodendroglia, Cell Death, Rats, Sprague-Dawley, Myelin Proteolipid Protein, Rats
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