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Cited by 48Phytoestrogen effects and researchNutritional Studies and DietCancer Risks and Factors

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Phyto-oestrogen Intake and Breast Cancer Risk in South Asian Women in England: Findings from a Population-based Case-Control Study

Silva, Isabel dos Santos, Mangtani, Punam, McCormack, Valerie, Bhakta, Dee, McMichael, Anthony J, Sevak, Leena·2004·Cancer Causes & Control
DOI 10.1023/b:caco.0000043431.85706.d8
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Abstract

Objective This study investigates whether intake of phyto-oestrogens is associated with breast cancer risk in South Asian women from the Indian subcontinent, whose diet is rich in pulses and vegetables but poor in soyfoods. Methods A total of 240 South Asian breast cancer cases living in England and 477 age-matched population-based controls were recruited into the study. Dietary intake was measured using a validated food frequency questionnaire. Conditional logistic regression models were used to estimate the effect of phyto-oestrogen intake on breast cancer risk. Results After adjustment for known breast cancer risk factors and total energy intake, there was moderate evidence of a dose-effect response in the odds of breast cancer with isoflavone intake (p-value for trend 0.08), with women in the top quartile having approximately half the odds of breast cancer of those in the bottom one (odds ratio (OR) 0.58, 95% confidence interval (CI) 0.33, 1.00) but with no reductions in the odds for women in the second and third quartiles. The ORs for second, third and highest quartiles of total lignan intake compared to the lowest were 0.78 (95% CI 0.48, 1.26), 0.74 (0.46, 1.19) and 0.66 (0.41, 1.07), respectively, again with moderate evidence of a linear dose-effect response (p-value for trend 0.09). Further adjustment for non-startch polysaccharides (NSP) intake slightly weakened the phyto-oestrogens-breast cancer associations. Conclusions These findings are consistent with the possib…

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  • The traditional Japanese diet contains between 6-11 g of soy protein and 25-50 mg isoflavones; top percentiles of soy intake in Asian studies consume as much as 20 g soy protein or 100 mg isoflavones per day, while the cut-off for top quartiles of intake among Western populations is in the range of a few hundred micrograms per day.

    “The traditional Japanese diet contains between 6-11g of soy protein and 25-50mg isoflavones; top percentiles of soy intake in Asian studies consume as much as 20g soy protein or 100mg isoflavones per day [188], while the cut off for the top quartiles of intake among Western populations is in the range of a few hundred micrograms (mcg) per day [52,74].”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [52]

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Metadata

Authors
Silva, I. D. S., Mangtani, P., McCormack, V., Bhakta, D., McMichael, A. J., & Sevak, L.
Affiliations
London School of Hygiene & Tropical Medicine (GB)
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
2004-10
Volume
15
Issue
8
Pages
805-818
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/b:caco.0000043431.85706.d8
OpenAlex
W1987171227
Cited by
48
References
1
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 3
FWCI
2.55
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
Funders
Cancer Research UK
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
phytoestrogens, breast cancer risk, isoflavones, lignans, South Asian women, dietary intake, non-starch polysaccharides, pulses, dose-response relationship, protective effect
MeSH terms
Adult, Aged, Asia, Southeastern, Breast Neoplasms, Diet, England, Female, Humans, Middle Aged, Risk Factors, Vegetables, Odds Ratio, Case-Control Studies, Phytoestrogens

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