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Fluorescence Glucose Detection: Advances Toward the Ideal In Vivo Biosensor
Abstract
The importance of glucose monitoring for in vivo as well as for ex vivo applications has driven a vast number of scientific groups to pursue the development of an advanced glucose sensor. Such a sensor must be robust, versatile, and capable of the long-term, accurate and reproducible detection of glucose levels in various testing media. Among the different configurations and signal transduction mechanisms used, fluorescence-based glucose sensors constitute a growing class of glucose sensors represented by an increasing number of significant contributions to the field over the last few years. This manuscript reviews the progress in the development of fluorescence based glucose sensors resulting from the advances in the design of new receptor systems for glucose recognition and the utilization of new fluorescence transduction schemes.
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“Photobleaching of the fluorophore and scattering in tissue are significant drawbacks.19,35–36”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [35]
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“While optical detection provides sensitive detection without damaging the host, skin pigmentation and epidermal thickness can negatively impact the analytical response among hosts.35–36”
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Metadata
- Authors
- Moschou, E. A., Sharma, B. V., Deo, S. K., & Daunert, S.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Daunert, Sylvia
- Venue
- Journal of Fluorescence
- Published
- 2004-09
- Volume
- 14
- Issue
- 5
- Pages
- 535-547
- ISSN
- 1053-0509 (ISSN-L)
- 1573-4994
- OpenAlex
- W2042531272
- Cited by
- 154
- References
- 49
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 14
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Fluorescence (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- glucose sensor, fluorescent biosensor, in vivo glucose monitoring, glucose recognition, glucose receptor
- MeSH terms
- Geobacillus stearothermophilus, Boronic Acids, Fluorescent Dyes, Fluorometry, Glucokinase, Glucose, Glucose Oxidase, Humans, Monitoring, Physiologic, Monosaccharide Transport Proteins, Mutation, Protein Conformation, Biosensing Techniques, Molecular Structure, Fluorescence Resonance Energy Transfer, Lectins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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