Cited by 551Psychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

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Reducing relapse and recurrence in unipolar depression: a comparative meta-analysis of cognitive-behavioral therapy’s effects

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Vittengl, Jeffrey R., Clark, Lee Anna, Dunn, Todd W., Jarrett, Robin B.·2007·Journal of Consulting and Clinical Psychology

DOI 10.1037/0022-006x.75.3.475PMC PMC2630051

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Abstract

Relapse and recurrence following response to acute-phase treatment for major depressive disorder (MDD) are prevalent and costly. In a meta-analysis of 28 studies including 1,880 adults, the authors reviewed the world's published literature on cognitive-behavioral therapies (CT) aimed at preventing relapse-recurrence in MDD. Results indicate that after discontinuation of acute-phase treatment, many responders to CT relapse-recur (29% within 1 year and 54% within 2 years). These rates appear comparable to those associated with other depression-specific psychotherapies but lower than those associated with pharmacotherapy. Among acute-phase treatment responders, continuation-phase CT reduced relapse-recurrence compared with assessment only at the end of continuation treatment (21% reduction) and at follow-up (29% reduction). Continuation-phase CT also reduced relapse-recurrence compared with other active continuation treatments at the end of continuation treatment (12% reduction) and at follow-up (14% reduction). The authors discuss implications for research and patient care and suggest directions, with methodological refinements, for future studies.

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Method

Authors: Vittengl, J. R., Clark, L. A., Dunn, T. W., & Jarrett, R. B.
Affiliations: Truman State University (US)
University of Iowa (US)
The University of Texas Southwestern Medical Center (US)
ORCID: Vittengl, Jeffrey R.
Clark, Lee Anna
Jarrett, Robin B.
Venue: Journal of Consulting and Clinical Psychology
Publisher: American Psychological Association (APA)
Published: 2007
Volume: 75
Issue: 3
Pages: 475-488
ISSN: 0022-006X (ISSN-L)
1939-2117
DOI: 10.1037/0022-006x.75.3.475
PMC: PMC2630051
OpenAlex: W1981386178
Cited by: 551
References: 102
Citations by year: 2026: 11 · 2025: 15 · 2024: 24 · 2023: 19 · 2022: 22 · 2021: 30 · 2020: 34 · 2019: 42 · 2018: 35 · 2017: 32 · 2016: 36 · 2015: 36 · 2014: 38 · 2013: 29 · 2012: 37
FWCI: 4.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Consulting and Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH-58397; MH-01571)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: major depressive disorder, relapse prevention, recurrence prevention, cognitive behavioral therapy, acute phase treatment, psychotherapy versus pharmacotherapy, treatment discontinuation
MeSH terms: Depressive Disorder, Humans, Recurrence, Cognitive Behavioral Therapy

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Reducing relapse and recurrence in unipolar depression: a comparative meta-analysis of cognitive-behavioral therapy’s effects

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