The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.
Reducing relapse and recurrence in unipolar depression: a comparative meta-analysis of cognitive-behavioral therapy’s effects
Open accessAbstract
Relapse and recurrence following response to acute-phase treatment for major depressive disorder (MDD) are prevalent and costly. In a meta-analysis of 28 studies including 1,880 adults, the authors reviewed the world's published literature on cognitive-behavioral therapies (CT) aimed at preventing relapse-recurrence in MDD. Results indicate that after discontinuation of acute-phase treatment, many responders to CT relapse-recur (29% within 1 year and 54% within 2 years). These rates appear comparable to those associated with other depression-specific psychotherapies but lower than those associated with pharmacotherapy. Among acute-phase treatment responders, continuation-phase CT reduced relapse-recurrence compared with assessment only at the end of continuation treatment (21% reduction) and at follow-up (29% reduction). Continuation-phase CT also reduced relapse-recurrence compared with other active continuation treatments at the end of continuation treatment (12% reduction) and at follow-up (14% reduction). The authors discuss implications for research and patient care and suggest directions, with methodological refinements, for future studies.
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In the citing paper
“However, numerous high-quality studies show that treatment effects wane and that the risk of relapse ranges from 29% to 51% in the first year after treatment completion 2-4 .”
From ChatGPT: five priorities for research (2023) · cites this paper as [4]
In the citing paper
“Meta-analyses focusing on psychological relapse prevention interventions for depressive disorders indicate that these interventions are effective in preventing relapse, with reductions of 22–50% in relapse [18, 44–48].”
From Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as [47]
In the citing paper
“approximately 40%–50% of patients relapse within 1–2 years of receiving treatment (8, 9).”
From A narrative review of digital biomarkers in the management of major depressive disorder and treatment-resistant forms (2023) · cites this paper as [9]
In the citing paper
“Significantly, fewer participants receiving ICBT experienced relapse compared with those in the control group (10.5 compared with 37.8%), which is in line with previous face-to-face studies [30].”
From Internet-based psychological treatments for depression (2012) · cites this paper as [30]
In the citing paper
“A number of psychological interventions have been developed that can be used to target such cognitive change in remitted depressed individuals, most notably cognitive-behavior therapy (CBT; Vittengl, Clark, Dunn, & Jarrett, 2007) and mindfulness-based cognitive therapy (MBCT; Segal, Williams, & Teasdale, 2012).”
From Beneficial effects of training in self-distancing and perspective broadening for people with a history of recurrent depression (2017) · cites this paper as Vittengl, Clark, Dunn, & Jarrett, 2007
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“The relapse prevention effect of psychological treatment particularly CBT, can be realized through acute and continuation phase interventions [56].”
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“Vittengl et al. [8] concluded that the relapse rates in depression were lower with CBT than with drug therapy or other active continuation treatments.”
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“However, while many patients benefit from these treatments, studies have found substantial rates of insufficient treatment response, non-response, and disease recurrence in others [5–8].”
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Background
Metadata
- Authors
- Vittengl, J. R., Clark, L. A., Dunn, T. W., & Jarrett, R. B.
- Affiliations
- Truman State University (US)
- University of Iowa (US)
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2007
- Volume
- 75
- Issue
- 3
- Pages
- 475-488
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- PMC
- PMC2630051
- OpenAlex
- W1981386178
- Cited by
- 551
- References
- 102
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 24 · 2023: 19 · 2022: 22 · 2021: 30 · 2020: 34 · 2019: 42 · 2018: 35 · 2017: 32 · 2016: 36 · 2015: 36 · 2014: 38 · 2013: 29 · 2012: 37
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-58397; MH-01571)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- major depressive disorder, relapse prevention, recurrence prevention, cognitive behavioral therapy, acute phase treatment, psychotherapy versus pharmacotherapy, treatment discontinuation
- MeSH terms
- Depressive Disorder, Humans, Recurrence, Cognitive Behavioral Therapy
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