Electrolytic lesions of the amygdala block acquisition and expression of fear-potentiated startle even with extensive training but do not prevent reacquisition.
Abstract
Lesions of the amygdala have been shown to block the expression of fear-potentiated startle (increased acoustic startle in the presence of a cue previously paired with shock). In the present study, bilateral lesions of the central nucleus of the amygdala given after extensive training totally blocked the expression of fear-potentiated startle but did not prevent reacquisition. In contrast, when the lesions were made before any training, the lesioned rats did not show potentiated startle even with extensive training. Thus, the central nucleus of the amygdala normally seems to be required for the initial acquisition and expression of potentiated startle regardless of the degree of learning. However, reacquisition of potentiated startle can occur without the central nucleus, which implies the presence of a secondary brain system that can compensate for the loss of the central nucleus of the amygdala under some circumstances.
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The central amygdala nucleus (CEA) has been implicated in learning and expression of fear responses, as well as the expression of stress-induced anxiety behaviors.
“Functionally, CEA has been implicated in learning and expression of fear responses,105, 106, 107 as well as the expression of stress-induced anxiety behaviors.108, 109, 110, 111, 112, 113”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [106]
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- Authors
- Kim, M., & Davis, M.
- Affiliations
- Yale University (US)
- Venue
- Behavioral Neuroscience
- Published
- 1993
- Volume
- 107
- Issue
- 4
- Pages
- 580-595
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2038679538
- Cited by
- 139
- References
- 5
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 25642, MH 47840, MH 00004, P01MH025642)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- amygdala, central amygdala, fear-potentiated startle, fear conditioning, acoustic startle response, reacquisition, learning acquisition, electrolytic lesions, rats
- MeSH terms
- Amygdala, Animals, Arousal, Brain Mapping, Brain Stem, Conditioning, Classical, Efferent Pathways, Fear, Male, Retention, Psychology, Reflex, Startle, Rats, Sprague-Dawley, Rats
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