Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
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In the standard model of pavlovian fear learning, sensory input from neutral and aversive stimuli converge in the lateral nucleus of the amygdala (LA), in which alterations in synaptic transmission encode the association. During fear expression, the LA is thought to engage the central nucleus of the amygdala (CE), which serves as the principal output nucleus for the expression of conditioned fear responses. In the present study, we reexamined the roles of LA and CE. Specifically, we asked whether CE, like LA, might also be involved in fear learning and memory consolidation. Using functional inactivation methods, we first show that CE is involved not only in the expression but also the acquisition of fear conditioning. Next, we show that inhibition of protein synthesis in CE after training impairs fear memory consolidation. These findings indicate that CE is not only involved in fear expression but, like LA, is also involved in the learning and consolidation of pavlovian fear conditioning.
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The central amygdala nucleus (CEA) has been implicated in learning and expression of fear responses, as well as the expression of stress-induced anxiety behaviors.
“Functionally, CEA has been implicated in learning and expression of fear responses,105, 106, 107 as well as the expression of stress-induced anxiety behaviors.108, 109, 110, 111, 112, 113”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [107]
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- Authors
- Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E.
- Affiliations
- Yale University (US)
- ORCID
- LeDoux, Joseph E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-11-29
- Volume
- 26
- Issue
- 48
- Pages
- 12387-12396
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6674909
- OpenAlex
- W1993630149
- Cited by
- 533
- References
- 72
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 17 · 2023: 16 · 2022: 11 · 2021: 23 · 2020: 26 · 2019: 18 · 2018: 29 · 2017: 25 · 2016: 35 · 2015: 37 · 2014: 27 · 2013: 46 · 2012: 31
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- W. M. Keck Foundation
- York University
- National Institute of Mental Health (R37 MH38774, R37MH038774, F31 MH63612, K05MH067048, F31MH063612, R01MH046516, R01-MH46516, MH38774)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- central amygdala, fear conditioning, fear memory consolidation, fear expression, fear learning, protein synthesis inhibition, functional inactivation, fear circuit
- MeSH terms
- Amygdala, Animals, Conditioning, Classical, Fear, Male, Nerve Net, Thinking, Rats, Sprague-Dawley, Rats
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