The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster)

In the citing paper

“Infusion of oxytocin into the brains of female prairie voles and vasopressin in males, for instance, facilitated pair-bonding even in the absence of actual mating (Cho et al. 1999; Insel and Hulihan 1995; Williams et al. 1994; Winslow et al. 1993).”

In the citing paper

“These findings are consistent with those reported for other mammals, particularly monogamous rodent species in which OT has shown to play a critical role in the formation of pair-bonds (Cho et al., 1999; Insel and Hulihan, 1995; Williams et al., 1994).”

In the citing paper

“However, nonspecific intracerebroventricular administration of OXT can induce a partner preference and bonding in both males and females (10).”

In the citing paper

“This mutant has a deficit in OT secretion and is also impaired in its ability to recognize familiar conspecifics.”

In the citing paper

“Expressing CD-38 in the hypothalamus using a lenti-viral vector or by infusing OT was able to rescue this deficit [21].”

In the citing paper

“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”

In the citing paper

“Because some of these sex-specific effects were dose-dependent and required a higher dose in one sex (i.e., role of VP on partner preference in prairie voles with higher doses required in females; Cho et al., 1999), this further suggests that such sex-specific effects may be the result of sex differences in sensitivity to VP or OT systems.”

In the citing paper

“Oxytocin (OT), a neuropeptide hormone found exclusively in mammals, is associated with maternal behavior (1,2) and adult pair-bond formation (partner preference) behavior (3,4) in rodents.”

In the citing paper

“Adult males are also responsive to OT, but require higher dosages than females to induce a partner preference (4).”

In the citing paper

“In male prairie voles, AVP plays a critical role in the regulation of partner preferences, although it is likely that OT also plays a role [18, 19].”

In the citing paper

“Although exogenous central OT infusions facilitate partner preference formation in both sexes (Cho et al., 1999)”

In the citing paper

“and central OT administration enhances partner preference formation in both females and males (Cho et al., 1999).”

In the citing paper

“Finally, oxytocin can also bind to AVPR1A receptors25, which have also been linked to social functioning26.”

In the citing paper

“Earlier work in voles has suggested that either OT or AVP may support a general tendency toward social contact (Cho et al., 1999).”

In the citing paper

“For instance, ICV administration of oxytocin or injection of oxytocin directly into the nucleus accumbens can induce partner preferences in absence of mating (Cho et al., 1999).”

In the citing paper

“OT has been shown to regulate fundamental mechanisms underlying mate fidelity.”

In the citing paper

“Blocking endogenous OT activity diminished a partner-preference and inhibited pair-bond formation in prairie voles (Cho et al., 1999).”

In the citing paper

“This behavioral pattern is consistent with findings in prairie voles that OT increases preferential associations with a pair-mate (Williams et al., 1994; Cho et al., 1999).”

In the citing paper

“In prairie voles, intracerebroventricular injections of OT induced a partner-preference in both males and females (Cho et al., 1999)”