Cited by 122Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning.

Baldwin, Anne E., Holahan, Matthew R., Sadeghian, Kenneth, Kelley, Ann E.·2000·Behavioral Neuroscience

Abstract

The effect of microinfusion of the N-methyl-D-aspartate (NMDA) antagonist 2-amino-5-phosphonopentanoic acid (AP-5) into the amygdala, medial prefrontal cortex, and dorsal and ventral subiculum on acquisition of a lever-pressing task for food in rats was examined. Serial transmission between the basolateral amygdala and nucleus accumbens core was also examined in an asymmetric infusion design. AP-5 administered bilaterally into either the amygdala or medial prefrontal cortex markedly impaired learning, whereas administration into the dorsal or ventral subiculum had no effect. Unilateral infusion of AP-5 into either the nucleus accumbens core or amygdala was also sufficient to impair learning. These data provide novel evidence for NMDA receptor-dependent plasticity within corticostriatal networks in the acquisition of appetitive instrumental learning.

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Crossref · 10.1037/0735-7044.114.1.84

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  • Plasticity in the LA is required for several forms of appetitively motivated learning.

    “In addition to being essential for aversively motivated learning, plasticity in the LA is also required for several forms of appetitively motivated learning (43–45) and a number of studies have found that separate populations of amygdala neurons mediate aversive and appetitive processing (46–48).”

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Authors
Baldwin, A. E., Holahan, M. R., Sadeghian, K., & Kelley, A. E.
Affiliations
University of Wisconsin–Madison (US)
Venue
Behavioral Neuroscience
Published
2000-02
Volume
114
Issue
1
Pages
84-98
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2012799106
Cited by
122
References
0
Citations by year
2026: 1 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 6
FWCI
6.52
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA-04788)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
NMDA receptor, NMDA receptor antagonists, AP5, corticostriatal network, basolateral amygdala, nucleus accumbens core, medial prefrontal cortex, dorsal subiculum, ventral subiculum, synaptic plasticity, food reward, lever pressing, serial communication
MeSH terms
Amygdala, Animals, Appetitive Behavior, Brain Mapping, Cerebral Cortex, Conditioning, Operant, Corpus Striatum, Hippocampus, Male, Nerve Net, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Rats

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