N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning.
Abstract
The effect of microinfusion of the N-methyl-D-aspartate (NMDA) antagonist 2-amino-5-phosphonopentanoic acid (AP-5) into the amygdala, medial prefrontal cortex, and dorsal and ventral subiculum on acquisition of a lever-pressing task for food in rats was examined. Serial transmission between the basolateral amygdala and nucleus accumbens core was also examined in an asymmetric infusion design. AP-5 administered bilaterally into either the amygdala or medial prefrontal cortex markedly impaired learning, whereas administration into the dorsal or ventral subiculum had no effect. Unilateral infusion of AP-5 into either the nucleus accumbens core or amygdala was also sufficient to impair learning. These data provide novel evidence for NMDA receptor-dependent plasticity within corticostriatal networks in the acquisition of appetitive instrumental learning.
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Plasticity in the LA is required for several forms of appetitively motivated learning.
“In addition to being essential for aversively motivated learning, plasticity in the LA is also required for several forms of appetitively motivated learning (43–45) and a number of studies have found that separate populations of amygdala neurons mediate aversive and appetitive processing (46–48).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [44]
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Kraft, T. T., Huang, D., LaMagna, S., Warshaw, D., Natanova, E., Sclafani, A. J., & Bodnar, R. J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.01.034 · Cited by 10 · see citing works
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Shih, C.-C., & Chang, C. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114682 · Cited by 4 · see citing works
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- Authors
- Baldwin, A. E., Holahan, M. R., Sadeghian, K., & Kelley, A. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Behavioral Neuroscience
- Published
- 2000-02
- Volume
- 114
- Issue
- 1
- Pages
- 84-98
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2012799106
- Cited by
- 122
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA-04788)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- NMDA receptor, NMDA receptor antagonists, AP5, corticostriatal network, basolateral amygdala, nucleus accumbens core, medial prefrontal cortex, dorsal subiculum, ventral subiculum, synaptic plasticity, food reward, lever pressing, serial communication
- MeSH terms
- Amygdala, Animals, Appetitive Behavior, Brain Mapping, Cerebral Cortex, Conditioning, Operant, Corpus Striatum, Hippocampus, Male, Nerve Net, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Rats
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