Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance
Abstract
Excitotoxic lesions of the medial frontal cortex and anterior cingulate cortex in rats have been shown to produce dissociable impairments on a reaction time visual attention (5-choice) task. Because these cortical areas project to the medial striatal region, the authors predicted similar deficits after lesions of this striatal area compared with the lateral area. Compared with sham-operated controls, rats with quinolinic acid-induced medial striatal lesions showed all the behavioral changes associated with medial frontal cortex and anterior cingulate cortex lesions. In contrast, lateral striatal lesions produced profound disturbances in the performance of the task. Control tests showed little evidence of gross deficits in either group of rats in terms of motivation, locomotor function, or Pavlovian appetitive conditioning. These data suggest that the medial and lateral striatum have contrasting roles in the control of instrumental responding related to the primary sources of their cortical innervation.
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Lesions of the medial striatum produce both perseverative and premature responding changes.
“Lesions of the medial striatum, a main projection area, produce both of these behavioral changes (Rogers et al., 2001).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Rogers et al., 2001
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- Authors
- Rogers, R. D., Baunez, C., Everitt, B. J., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Venue
- Behavioral Neuroscience
- Published
- 2001
- Volume
- 115
- Issue
- 4
- Pages
- 799-811
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2013276895
- Cited by
- 140
- References
- 72
- Citations by year
- 2026: 1 · 2025: 3 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 11 · 2013: 11 · 2012: 6
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- medial striatum, lateral striatum, attention, visual attention, reaction time, quinolinic acid lesion, excitotoxic lesions, medial frontal cortex, anterior cingulate cortex, instrumental responding, motivation, locomotor function
- MeSH terms
- Animals, Attention, Choice Behavior, Conditioning, Classical, Male, Models, Neurological, Reaction Time, Visual Perception, Neostriatum, Rats
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