Dissociation of attention in learning and action: effects of lesions of the amygdala central nucleus, medial prefrontal cortex, and posterior parietal cortex
Open accessAbstract
Many associative learning theories assert that the predictive accuracy of events affects the allocation of attention to them. More reliable predictors of future events are usually more likely to control action based on past learning, but less reliable predictors are often more likely to capture attention when new information is acquired. Previous studies showed that a circuit including the amygdala central nucleus (CEA) and the cholinergic substantia innominata/nucleus basalis magnocellularis (SI/nBM) is important for both sustained attention guiding action in a five-choice serial reaction time (5CSRT) task and for enhanced new learning about less predictive cues in a serial conditioning task. In this study, the authors found that lesions of the cholinergic afferents of the medial prefrontal cortex interfered with 5CSRT performance but not with surprise-induced enhancement of learning, whereas lesions of cholinergic afferents of posterior parietal cortex impaired the latter effects but did not affect 5CSRT performance. CEA lesions impaired performance in both tasks. These results are consistent with the view that CEA affects these distinct aspects of attention by influencing the activity of separate, specialized cortical regions via modulation of SI/nBM.
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Task-related and exploratory attention rely on separate neural circuits involving the medial frontal cortex versus the substantia nigra, amygdala, and parietal lobe.
“Neuropsychological studies in rats suggest that task-related and exploratory attention rely on separate neural circuits that involve, respectively, the medial frontal cortex (Maddux and Holland, 2011) versus the substantia nigra, amygdala and the parietal lobe (Maddux et al., 2007).”
From Attention, learning, and the value of information (2012) · cites this paper as Maddux et al., 2007
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“Neuropsychological studies in rats suggest that task-related and exploratory attention rely on separate neural circuits that involve, respectively, the medial frontal cortex (Maddux and Holland, 2011) versus the substantia nigra, amygdala and the parietal lobe (Maddux et al., 2007).”
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- Authors
- Maddux, J.-M., Kerfoot, E. C., Chatterjee, S., & Holland, P. C.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2007-02
- Volume
- 121
- Issue
- 1
- Pages
- 63-79
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC2853715
- OpenAlex
- W2166376912
- Cited by
- 67
- References
- 84
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 7
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R37MH053667)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attentional capture, associative learning, central amygdala, medial prefrontal cortex, posterior parietal cortex, nucleus basalis magnocellularis, substantia innominata, cholinergic afferents, serial reaction time task, lesion studies
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Attention, Behavior, Animal, Choice Behavior, Conditioning, Classical, Learning, Male, Parietal Lobe, Reaction Time, Prefrontal Cortex, Rats, Long-Evans, Rats
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