Dissociable control of impulsivity in rats by dopamine D2/3 receptors in the core and shell subregions of the nucleus accumbens
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Previous research has identified the nucleus accumbens (NAcb) as an important brain region underlying inter-individual variation in impulsive behavior. Such variation has been linked to decreased dopamine (DA) D2/3 receptor availability in the ventral striatum of rats exhibiting spontaneously high levels of impulsivity on a 5-choice serial reaction time (5-CSRT) test of sustained visual attention. This study investigated the involvement of DA D2/3 receptors in the NAcb core (NAcbC) and the NAcb shell (NAcbS) in impulsivity. We investigated the effects of a DA D2/3 receptor antagonist (nafadotride) and a DA D2/3 partial agonist (aripiprazole) infused directly into either the NAcbC or NAcbS of rats selected for high (HI) and low (LI) impulsivity on the 5-CSRT task. Nafadotride increased significantly the level of impulsivity when infused into the NAcbS, but decreased impulsivity when infused into the NAcbC of HI rats. By contrast, intra-NAcb microinfusions of aripiprazole did not affect impulsivity. Systemic administration of nafadotride had no effect on impulsive behavior but increased the number of omissions and correct response latencies, whereas systemic injections of aripiprazole decreased impulsive and perseverative behavior, and increased the number of omissions and correct response latencies. These findings indicate an opponent modulation of impulsive behavior by DA D2/3 receptors in the NAcbS and NAcbC. Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction.
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Peripheral administration of a D2 receptor antagonist increases impulsivity, as does intra-accumbens shell administration.
“Moreover, peripheral administration of D2 receptor antagonist increases impulsivity (Wade et al., 2000) as does intra-accumbens shell administration (Besson et al., 2010).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Besson et al., 2010
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- Authors
- Besson, M., Belin, D., McNamara, R., Theobald, D. E., Castel, A., Beckett, V. L., Crittenden, B. M., Newman, A. H., Everitt, B. J., Robbins, T. W., & Dalley, J. W.
- Affiliations
- University of Cambridge (GB)
- National Institutes of Health (US)
- Corresponding author
- Dalley, Jeffrey W
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2009-10-21
- Volume
- 35
- Issue
- 2
- Pages
- 560-569
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055378
- OpenAlex
- W2054111217
- Cited by
- 143
- References
- 53
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 12 · 2013: 25 · 2012: 6
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (076274)
- Medical Research Council
- National Institute on Drug Abuse
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- impulsivity, dopamine D2/D3 receptors, nucleus accumbens, nucleus accumbens core, nucleus accumbens shell, aripiprazole, 5-choice serial reaction time task, sustained visual attention, perseveration, interindividual variability, attention deficit hyperactivity disorder, drug addiction
- MeSH terms
- Aripiprazole, Analysis of Variance, Animals, Attention, Choice Behavior, Dose-Response Relationship, Drug, Drug Administration Routes, Impulsive Behavior, Male, Naphthalenes, Neuropsychological Tests, Nucleus Accumbens, Piperazines, Pyrrolidines, Reaction Time, Quinolones, Receptors, Dopamine D2, Dopamine Antagonists, Receptors, Dopamine D3, Rats, Dopamine D2 Receptor Antagonists
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