The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Effects of D-cycloserine on extinction of conditioned freezing.
Abstract
The present study tested the prediction that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, would facilitate extinction of conditioned freezing in male Sprague-Dawley rats. Rats received 5 light-shock pairings (conditioning). The following day, rats received 6 light-alone presentations (extinction training). Twenty-four hours later, rats received 1 light-alone presentation (test). Subcutaneous DCS injection before or after extinction training significantly enhanced extinction, and the dose-response curve for this effect was linear. Increasing the delay of DCS administration after extinction training led to a linear decrease in the facilitatory effect. The effect of systemic administration was replicated by intra-basolateral amygdala infusion. These results suggest that DCS facilitates extinction of conditioned freezing by acting on consolidation processes partly mediated by the basolateral amygdala.
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In the citing paper
“administration of the NMDAR partial agonist D-cycloserine (DCS) enhances the acquisition of the extinction memory”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Ledgerwood et al., 2003
In the citing paper
“with no effect when administered after re-exposure in rodents (Ledgerwood et al., 2003; Lee et al., 2006a)”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Ledgerwood et al., 2003
In the citing paper
“Preclinical research has demonstrated that DCS facilitates extinction learning and memory in rodent models (Davis et al, 2006; Ledgerwood et al, 2003; Walker et al, 2002).”
From D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial (2014) · cites this paper as Ledgerwood et al, 2003
In the citing paper
“We chose weekly dosing, administered 90 min before exposure sessions, as this regimen has been effective in multiple animal and human fear extinction studies (Ledgerwood et al, 2003; Ressler et al, 2004; Walker et al, 2002)”
From D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial (2014) · cites this paper as Ledgerwood et al, 2003
In the citing paper
“administration of D-cycloserine (DCS), a partial agonist of the NMDA receptor involved in long-term potentiation (a cellular model of learning), facilitates extinction (e.g., Walker, Ressler, Lu, & Davis, 2002; Ledgerwood, Richardson, & Cranney, 2003).”
From D-cycloserine facilitates context-specific fear extinction learning (2008) · cites this paper as Ledgerwood, Richardson, & Cranney, 2003
In the citing paper
“Our results are generally in agreement with the results of Walker et al (2002) and Ledgerwood et al (2003), in which DCS systemic administration enhanced the extinction of conditioned fear.”
From Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD (2008) · cites this paper as Ledgerwood et al (2003)
In the citing paper
“Likewise, though the molecular mechanism of contextual fear extinction remains to be precisely determined, the N-methyl-D-aspartate (NMDA) receptor appears to play a critical role in fear extinction (Falls et al, 1992;Ledgerwood et al, 2003Ledgerwood et al, , 2004Ledgerwood et al, , 2005;;Rodrigues et al, 2001;Santini et al, 2001;Walker et al, 2002).”
From Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD (2008) · cites this paper as Ledgerwood et al, 2003
In the citing paper
“The DCS dose (15 mg/kg per rat) was chosen on the basis of the results of other behavioral studies (Ledgerwood et al, 2003(Ledgerwood et al, , 2005;;Walker et al, 2002).”
From Effects of Single Prolonged Stress and D-Cycloserine on Contextual Fear Extinction and Hippocampal NMDA Receptor Expression in a Rat Model of PTSD (2008) · cites this paper as Ledgerwood et al, 2003
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Neurobiology of Pavlovian fear conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,543
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain
Monaghan, D., & Cotman, C. W. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-11-02909.1985 · Cited by 1,279
NMDA receptors - their role in long-term potentiation
Collingridge, G. L., & Bliss, T. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90175-5 · Cited by 1,178
Aguado Aguilar, L. (2001) · PubMed · Cited by 1,072
Neural organization of the defensive behavior system responsible for fear
Fanselow, M. S. (1994) · Psychonomic Bulletin & Review · doi:10.3758/bf03210947 · Cited by 1,000
From normal fear to pathological anxiety.
Rosen, J. B., & Schulkin, J. A. (1998) · Psychological Review · doi:10.1037/0033-295x.105.2.325 · Cited by 914
A perceptual-defensive-recuperative model of fear and pain
Bolles, R. C., & Fanselow, M. S. (1980) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0000491x · Cited by 840
Miserendino, M. J. D., Sananes, C. B., Melia, K. R., & Davis, M. (1990) · Nature · doi:10.1038/345716a0 · Cited by 824
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815
Handbook of Contemporary Learning Theories
Mowrer, R. R. (2000) · Psychology Press eBooks · doi:10.4324/9781410600691 · Cited by 787
Innate and conditioned reactions to threat in rats with amygdaloid lesions.
Blanchard, D. C., & Blanchard, R. J. (1972) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0033521 · Cited by 753
Molecular mechanisms of memory acquisition, consolidation and retrieval
Abel, T. G., & Lattal, K. M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00194-x · Cited by 709
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673
Bourtchouladze, R., Abel, T., Berman, N., Gordon, R., Lapidus, K., & Kandel, E. R. (1998) · Learning & Memory · doi:10.1101/lm.5.4.365 · Cited by 525
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1365 · Cited by 385
Fanselow, M. S., & Kim, J. J. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.210 · Cited by 360
Santini, E., Muller, R. U., & Quirk, G. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-22-09009.2001 · Cited by 358
Fanselow, M. S., & Kim, J. J. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.210 · Cited by 337
Amygdalar NMDA Receptors are Critical for New Fear Learning in Previously Fear-Conditioned Rats
Lee, H. J., & Kim, J. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08444.1998 · Cited by 310
d-Cycloserine: A ligand for the coupled glycine receptor has partial agonist characteristics
Hood, W. F., Compton, R. P., & Monahan, J. B. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90379-0 · Cited by 309
Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1365 · Cited by 260
Monahan, J. B., Handelmann, G. E., Hood, W. F., & Cordi, A. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90571-6 · Cited by 257
Campeau, S., Miserendino, M. J. D., & Davis, M. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.3.569 · Cited by 255
Campeau, S., Miserendino, M. J. D., & Davis, M. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.3.569 · Cited by 221
Psychosocial treatment of posttraumatic stress disorder.
Foa, E. B. (2000) · PubMed · Cited by 210
Handbook of behavior therapy and psychological science: an integrative approach
(1991) · Choice Reviews Online · doi:10.5860/choice.29-1790 · Cited by 194
Imagery in human classical conditioning.
Dadds, M. R., Bovbjerg, D. H., Redd, W. H., & Cutmore, T. R. H. (1997) · Psychological Bulletin · doi:10.1037/0033-2909.122.1.89 · Cited by 186
Watson, G. B., Bolanowski, M. A., Baganoff, M. P., Deppeler, C. L., & Lanthorn, T. H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90745-w · Cited by 172
Rescorla, R. A. (2000) · PsycEXTRA Dataset · doi:10.1037/e413792005-865 · Cited by 166
Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor
Flood, J. F., Morley, J. E., & Lanthorn, T. H. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90709-d · Cited by 153
Zhang, W. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00256-x · Cited by 137
Modulation of memory processing by glutamic acid receptor agonists and antagonists
Flood, J. F., Baker, M. L., & Davis, J. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)91543-p · Cited by 111
Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents
Handelmann, G. E., Nevins, M. E., Mueller, L. L., Arnolde, S. M., & Cordi, A. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90281-5 · Cited by 90
Matsuoka, N., & Aigner, T. G. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20677-2 · Cited by 82
Cox, J., & Westbrook, R. F. (1994) · PubMed · Cited by 74
Handbook of behavior therapy and psychological science: An integrative approach
Galassi, J. P. (1992) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(92)90012-8 · Cited by 74
Conditioned Reflexes and Neuronal Organization
Szumski, A. J. (1970) · Physical Therapy · doi:10.1093/ptj/50.2.297b · Cited by 73
Priestley, T., & Kemp, J. A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09868-2 · Cited by 68
Löscher, W., Właź, P., Rundfeldt, C., Baran, H., & Hönack, D. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13036.x · Cited by 66
Land, C., & Riccio, D. C. (1999) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3897 · Cited by 61
Pussinen, R., Nieminen, S. A., Koivisto, E., Haapalinna, A., Riekkinen, P. J., & Sirviö, J. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3738 · Cited by 42
Land, C. L., & Riccio, D. C. (1997) · Psychobiology · doi:10.3758/bf03331929 · Cited by 29
Manipulation of NMDA-receptor activity alters extinction of an instrumental response in rats
Port, R. L., & Seybold, K. S. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00095-x · Cited by 25
Steele, R. J., Dermon, C. R., & Stewart, M. G. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0064 · Cited by 21
Effects of putative cognition enhancers on the NMDA receptor by [3H]MK801 binding
Hamelin, S. M., & Lehmann, J. C. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00432-k · Cited by 7
Flagged first, then by citations
Research works printed but not linked: 1
- Bouton, 1991, A contextual analysis of fear extinction., 435
Cited by
Sorted by citations
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841
Metadata
- Authors
- Ledgerwood, L., Richardson, R., & Cranney, J.
- Affiliations
- UNSW Sydney (AU)
- Venue
- Behavioral Neuroscience
- Published
- 2003
- Volume
- 117
- Issue
- 2
- Pages
- 341-349
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2129939370
- Cited by
- 388
- References
- 46
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 16 · 2017: 19 · 2016: 10 · 2015: 16 · 2014: 18 · 2013: 28 · 2012: 25
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- D-cycloserine, extinction, conditioned freezing, NMDA receptor agonist, basolateral amygdala, memory consolidation, fear extinction, dose-response relationship
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Brain Mapping, Conditioning, Psychological, Cycloserine, Dose-Response Relationship, Drug, Drug Administration Routes, Extinction, Psychological, Male, Reflex, Startle, Time Factors, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Rats
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