D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response
Abstract
The effect of D-cycloserine (DCS), an NMDA partial agonist, on extinction of fear was investigated in rats using the conditioned emotional response preparation. Fear extinction was facilitated when the first 4 trials occurred with a 30-mg/kg dose of DCS. However, extinguished fear was "renewed" regardless of the drug treatment when the rats were returned to the context in which fear had been conditioned. Additional results suggest that DCS's facilitation of extinction is a small but meaningful effect in the current method. The results suggest caution regarding the use of DCS as an adjunct to extinction: Although the drug may modestly facilitate extinction learning, it does not necessarily destroy the potential for relapse. Behavioral mechanisms are discussed.
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In a re-analysis of a null-finding animal study, a significant DCS augmentation effect was seen only for animals that had demonstrated stronger extinction learning.
“Likewise, in a re-analysis of a null-finding study (3) of DCS augmentation, Bouton and colleagues (8) subsequently performed a median split of their sample based on the extinction effects during the drug session; again, a significant DCS augmentation effect was seen only for the animals that had demonstrated stronger extinction learning.”
From D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: evidence from the treatment of height phobia (2013) · cites this paper as [3]
Woods and Bouton (2006) found that although DCS facilitated fear loss in extinction, it did not weaken the renewal effect.
“Woods and Bouton (2006) found that although DCS facilitated fear loss in extinction, it did not weaken the renewal effect.”
From D-cycloserine facilitates context-specific fear extinction learning (2008) · cites this paper as Woods and Bouton (2006)
In two unpublished experiments, DCS had no demonstrable effect on extinction learning.
“In two unpublished experiments, DCS had no demonstrable effect on extinction learning.”
From D-cycloserine facilitates context-specific fear extinction learning (2008) · cites this paper as Woods and Bouton (2006)
The equivalent renewal result replicates, in the freezing preparation, the results of Woods and Bouton (2006) in the conditioned suppression preparation.
“That result replicates, in the freezing preparation, the results of Woods and Bouton (2006) in the conditioned suppression preparation.”
From D-cycloserine facilitates context-specific fear extinction learning (2008) · cites this paper as Woods and Bouton (2006)
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- Authors
- Woods, A. M., & Bouton, M. E.
- Affiliations
- University of Vermont (US)
- ORCID
- Bouton, Mark E.
- Venue
- Behavioral Neuroscience
- Published
- 2006
- Volume
- 120
- Issue
- 5
- Pages
- 1159-1162
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2077803253
- Cited by
- 133
- References
- 26
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 11
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (RO1 MH64847)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- D-cycloserine, fear extinction, conditioned emotional response, NMDA receptor partial agonist, fear conditioning, relapse
- MeSH terms
- Animals, Antimetabolites, Association Learning, Conditioning, Classical, Cycloserine, Dose-Response Relationship, Drug, Extinction, Psychological, Fear, Female, Nitroso Compounds, Mental Recall, Rats, Wistar, Rats
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