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D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response

Woods, Amanda M., Bouton, Mark E.·2006·Behavioral Neuroscience

DOI 10.1037/0735-7044.120.5.1159

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Abstract

The effect of D-cycloserine (DCS), an NMDA partial agonist, on extinction of fear was investigated in rats using the conditioned emotional response preparation. Fear extinction was facilitated when the first 4 trials occurred with a 30-mg/kg dose of DCS. However, extinguished fear was "renewed" regardless of the drug treatment when the rats were returned to the context in which fear had been conditioned. Additional results suggest that DCS's facilitation of extinction is a small but meaningful effect in the current method. The results suggest caution regarding the use of DCS as an adjunct to extinction: Although the drug may modestly facilitate extinction learning, it does not necessarily destroy the potential for relapse. Behavioral mechanisms are discussed.

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Authors: Woods, A. M., & Bouton, M. E.
Affiliations: University of Vermont (US)
ORCID: Bouton, Mark E.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2006
Volume: 120
Issue: 5
Pages: 1159-1162
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.120.5.1159
OpenAlex: W2077803253
Cited by: 133
References: 26
Citations by year: 2026: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 11
FWCI: 4.83
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (RO1 MH64847)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: D-cycloserine, fear extinction, conditioned emotional response, NMDA receptor partial agonist, fear conditioning, relapse
MeSH terms: Animals, Antimetabolites, Association Learning, Conditioning, Classical, Cycloserine, Dose-Response Relationship, Drug, Extinction, Psychological, Fear, Female, Nitroso Compounds, Mental Recall, Rats, Wistar, Rats

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D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response

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