Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction.

Han, Doug Hyun; Hwang, Jun Won; Renshaw, Perry F.

doi:10.1037/a0020023

Cited by 324Impact of Technology on AdolescentsGambling Behavior and TreatmentsSubstance Abuse Treatment and Outcomes

Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction.

Han, Doug Hyun, Hwang, Jun Won, Renshaw, Perry F.·2010·Experimental and Clinical Psychopharmacology

DOI 10.1037/a0020023

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Abstract

Bupropion has been used in the treatment of patients with substance dependence based on its weak inhibition of dopamine and norepinephrine reuptake. We hypothesized that 6 weeks of bupropion sustained release (SR) treatment would decrease craving for Internet game play as well as video game cue-induced brain activity in patients with Internet video game addiction (IAG). Eleven subjects who met criteria for IAG, playing StarCraft (>30 hr/week), and eight healthy comparison subjects (HC) who had experience playing StarCraft (<3 days/week and <1 hr/day). At baseline and at the end of 6 weeks of bupropion SR treatment, brain activity in response to StarCraft cue presentation was assessed using 1.5 Tesla functional MRI. In addition, symptoms of depression, craving for playing the game, and the severity of Internet addiction were evaluated by Beck Depression Inventory, self-report of craving on a 7-point visual analogue scale, and Young's Internet Addiction Scale, respectively. In response to game cues, IAG showed higher brain activation in left occipital lobe cuneus, left dorsolateral prefrontal cortex, and left parahippocampal gyrus than HC. After a 6 week period of bupropion SR, craving for Internet video game play, total game play time, and cue-induced brain activity in dorsolateral prefrontal cortex were decreased in the IAG. We suggest that bupropion SR may change craving and brain activity in ways that are similar to those observed in individuals with substance abuse or dependence.

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Problem gaming can be a primary diagnosis, but in other cases it may be a secondary clinical issue, for example arising as a maladaptive coping strategy or compensatory mechanism.
“Studies examining problem gaming and co-occurring diagnoses have noted that the former can be a primary diagnosis 148,153,154 , but in other cases may be a secondary clinical issue, for example, arising as a maladaptive coping strategy or compensatory mechanism 155 .”
From Emerging experience with selected new categories in the <scp>ICD</scp>‐11: complex <scp>PTSD</scp>, prolonged grief disorder, gaming disorder, and compulsive sexual behaviour disorder (2022) · cites this paper as [153]

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Authors: Han, D. H., Hwang, J. W., & Renshaw, P. F.
Affiliations: Chung-Ang University (KR)
Eulji University (KR)
University of Utah (US)
ORCID: Han, Doug Hyun
Renshaw, Perry F.
Venue: Experimental and Clinical Psychopharmacology
Publisher: American Psychological Association (APA)
Published: 2010-08
Volume: 18
Issue: 4
Pages: 297-304
ISSN: 1064-1297 (ISSN-L)
1936-2293
DOI: 10.1037/a0020023
OpenAlex: W2003027127
Cited by: 324
References: 44
Citations by year: 2026: 6 · 2025: 12 · 2024: 11 · 2023: 26 · 2022: 16 · 2021: 16 · 2020: 16 · 2019: 20 · 2018: 17 · 2017: 34 · 2016: 32 · 2015: 35 · 2014: 33 · 2013: 17 · 2012: 25
FWCI: 51.64
Type: journal article
Language: en
Open access: closed
Locations: Experimental and Clinical Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA015116)
Chung-Ang University
Topics: Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: bupropion sustained release, craving, dorsolateral prefrontal cortex, dopamine uptake inhibition, norepinephrine reuptake inhibition, StarCraft, depression, functional MRI
MeSH terms: Adolescent, Adult, Brain, Cues, Delayed-Action Preparations, Humans, Magnetic Resonance Imaging, Male, Motivation, Visual Perception, Bupropion, Behavior, Addictive, Prefrontal Cortex, Antidepressive Agents, Second-Generation, Video Games, Substance-Related Disorders, Internet, Young Adult

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Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction.

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