Animal models of prefrontal-executive function

Chudasama, Yogita

doi:10.1037/a0023766

Cited by 149Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorHistorical and Modern Theater Studies

Animal models of prefrontal-executive function

Chudasama, Yogita·2011·Behavioral Neuroscience

DOI 10.1037/a0023766

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Abstract

Executive function allows us to interact with the world in a purposive, goal-directed manner. It relies on several cognitive control operations that are mediated by different regions of the prefrontal cortex. While much of our knowledge about the functional subdivisions of the prefrontal cortex comes from the systematic assessment of patients with brain damage, animal models have served as the predominant tool for investigating specific structure-function relationships within the prefrontal cortex, especially as they relate to complex executive behaviors. These studies generally involve the targeted disruption of neural circuits combined with behavioral testing using carefully designed cognitive paradigms. In this review, I will describe a broad range of such experiments conducted in rats and monkeys that together reveal the distinct contributions of dorsal, medial, and ventral prefrontal cortex to different aspects of executive function. The effects of lesions and local pharmacological manipulations have provided valuable insights into the neural underpinnings of executive function and its neurochemical modulation. Despite the challenges associated with establishing a precise homology between animal models of prefrontal function and the human brain, such models currently offer the best means to systematically investigate the cognitive building blocks of executive function. This helps define the neural circuits that lead to a range of neurological and psychiatric disorders and facilitate the development of effective therapeutic strategies to ameliorate the associated cognitive impairments.

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The rodent PFC participates in functions such as attention, decision making and memory.
“Like in primates, the PFC in rodents is considered to participate in functions such as attention, decision making and memory (Chudasama, 2011; Dalley et al., 2004; Preston and Eichenbaum, 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chudasama, 2011

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Authors: Chudasama, Y.
Affiliations: McGill University (CA)
Corresponding author: Chudasama, Yogita
ORCID: Chudasama, Yogita
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2011
Volume: 125
Issue: 3
Pages: 327-343
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/a0023766
OpenAlex: W2069271056
Cited by: 149
References: 11
Citations by year: 2026: 1 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 19 · 2014: 9 · 2013: 19 · 2012: 14
FWCI: 6.98
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Sciences and Engineering Research Council
Canadian Institutes of Health Research
Canadian Foundation for Innovation (CFI)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords: executive function, prefrontal cortex, dorsal prefrontal cortex, medial prefrontal cortex, ventral prefrontal cortex, cognitive control, lesion studies, pharmacological manipulation, rats, monkeys, structure-function relationship, cognitive impairment, mental illness
MeSH terms: Animals, Attention, Decision Making, Impulsive Behavior, Memory, Short-Term, Neural Pathways, Reversal Learning, Reward, Space Perception, Visual Perception, Prefrontal Cortex, Models, Animal, Executive Function

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