Basolateral amygdala lesions facilitate reward choices after negative feedback in rats
Open accessAbstract
The orbitofrontal cortex (OFC) and basolateral amygdala (BLA) constitute part of a neural circuit important for adaptive, goal-directed learning. One task measuring flexibility of response to changes in reward is discrimination reversal learning. Damage to OFC produces well documented impairments on various forms of reversal learning in rodents, monkeys, and humans. Recent reports show that BLA, though highly interconnected with OFC, may be differentially involved in reversal learning. In the present experiment, we compared the effects of bilateral, ibotenic acid lesions of OFC or BLA (or SHAM) on visual discrimination and reversal learning. Specifically, we used pairwise visual discrimination methods, as is commonly administered in non-human primate studies, and analyzed how animals use positive and negative trial-by-trial feedback, domains not previously explored in a rat study. As expected, OFC lesions displayed significantly slower reversal learning than SHAM and BLA rats across sessions. Rats with BLA lesions, conversely, showed facilitated reversal learning relative to SHAM and OFC groups. Furthermore, a trial-by-trial analysis of the errors committed showed the BLA group benefited more from incorrectly performed trials (or negative feedback) on future choices than either SHAM or OFC rats. This provides evidence that BLA and OFC are involved in updating responses to changes in reward contingency and that the roles are distinct. Our results are discussed in relation to a competitive framework model for OFC and BLA in reward processing.
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The striatum, amygdala, and hippocampus are important for reversal learning.
“Other brain regions important for reversal learning are the striatum (Cools et al 2002, Rogers et al 2000), amygdala (Izquierdo et al 2013, Schoenbaum et al 2003, Wassum & Izquierdo 2015) and the hippocampus (Mala et al 2015).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Izquierdo et al 2013
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- Authors
- Izquierdo, A., Darling, C., Manos, N., Pozos, H., Kim, C., Ostrander, S., Cazares, V., Stepp, H., & Rudebeck, P. H.
- Affiliations
- California State University Los Angeles (US)
- National Institutes of Health (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-02-27
- Volume
- 33
- Issue
- 9
- Pages
- 4105-4109
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3606920
- OpenAlex
- W2048745224
- Cited by
- 63
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 1 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 2
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (SC2MH087974)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, orbitofrontal cortex, reversal learning, discrimination reversal learning, negative feedback, reward contingency, trial-by-trial feedback, ibotenic acid lesions, goal-directed learning, reward processing, rats
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Choice Behavior, Conditioning, Operant, Discrimination Learning, Feedback, Food Preferences, Ibotenic Acid, Male, Photic Stimulation, Reversal Learning, Reward, Prefrontal Cortex, Excitatory Amino Acid Agonists, Rats, Long-Evans, Rats
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