Dendritic spine changes associated with normal aging

Life and Death of Neurons in the Aging Brain

Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344 · see citing works

Influence of dendritic structure on firing pattern in model neocortical neurons

Mainen, Z. F., & Sejnowski, T. J. (1996) · Nature · doi:10.1038/382363a0 · Cited by 1,231 · see citing works

Executive Functioning as a Potential Mediator of Age-Related Cognitive Decline in Normal Adults.

Salthouse, T. A., Atkinson, T. M., & Berish, D. E. (2003) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.132.4.566 · Cited by 1,057 · see citing works

Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting

Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works

The ageing cortical synapse: hallmarks and implications for cognitive decline

Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works

Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex

Radley, J. J., Sisti, H. M., Hao, J., Rocher, A. B., McCall, T., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.006 · Cited by 769 · see citing works

Age-Related Impairment in Executive Functioning: Updating, Inhibition, Shifting, and Access

Fisk, J. E., & Sharp, C. A. (2004) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490510680 · Cited by 634 · see citing works

Propagation of action potentials in dendrites depends on dendritic morphology

Vetter, P., Roth, A., & Häusser, M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.926 · Cited by 598 · see citing works

The effects of normal aging on myelin and nerve fibers: a review

Peters, A. (2002) · Journal of Neurocytology · doi:10.1023/a:1025731309829 · Cited by 577 · see citing works

Neuronal basis of age-related working memory decline

Wang, M., Gamo, N. J., Yang, Y., Jin, L. E., Wang, X.-J., Laubach, M., Mazer, J. A., Lee, D., & Arnsten, A. F. T. (2011) · Nature · doi:10.1038/nature10243 · Cited by 485 · see citing works

Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

Dumitriu, D., Hao, J., Hara, Y., Kaufmann, J., Janssen, W. G. M., Lou, W., Rapp, P. R., & Morrison, J. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6410-09.2010 · Cited by 439 · see citing works

Regional Dendritic and Spine Variation in Human Cerebral Cortex: a Quantitative Golgi Study

Jacobs, B. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.558 · Cited by 423 · see citing works

The aging brain: morphomolecular senescence of cortical circuits

Hof, P. R., & Morrison, J. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.013 · Cited by 411 · see citing works

Circuit-Specific Alterations in Hippocampal Synaptophysin Immunoreactivity Predict Spatial Learning Impairment in Aged Rats

Smith, T. D., Adams, M., Gallagher, M., Morrison, J., & Rapp, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06587.2000 · Cited by 404 · see citing works

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works

Progressive dendritic changes in aging human cortex

Scheibel, M. E., Lindsay, R. D., Tomiyasu, U., & Scheibel, A. B. (1975) · Experimental Neurology · doi:10.1016/0014-4886(75)90072-2 · Cited by 365 · see citing works

Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

Goldman‐Rakic, P. S., & Brown, R. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90053-1 · Cited by 357 · see citing works

Cyclic Estrogen Replacement Improves Cognitive Function in Aged Ovariectomized Rhesus Monkeys

Rapp, P. R., Morrison, J. H., & Roberts, J. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05708.2003 · Cited by 352 · see citing works

Normal aging: regionally specific changes in hippocampal synaptic transmission

Barnes, C. A. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90029-9 · Cited by 334 · see citing works

Aging of the human cerebellum: A stereological study

Andersen, B. B., Gundersen, H. J. G., & Pakkenberg, B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10884 · Cited by 334 · see citing works

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery

Goldwater, D. S., Pavlides, C., Hunter, R. G., Bloss, E. B., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.053 · Cited by 333 · see citing works

Age-related Dendritic and Spine Changes in Corticocortically Projecting Neurons in Macaque Monkeys

Duan, H. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.9.950 · Cited by 317 · see citing works

Age-Related Differences in Performance on the Wisconsin Card Sorting Test: A Meta-Analytic Review.

Rhodes, M. G. (2004) · Psychology and Aging · doi:10.1037/0882-7974.19.3.482 · Cited by 310 · see citing works

Patterns of cognitive decline in aged rhesus monkeys

Herndon, J. G., Moss, M. B., Rosene, D. L., & Killiany, R. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02256-5 · Cited by 290 · see citing works

Age‐related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique

Geinisman, Y., de Toledo-Morrell, L., Morrell, F., Persina, I. S., & Rossi, M. (1992) · Hippocampus · doi:10.1002/hipo.450020411 · Cited by 264 · see citing works

Estrogen Alters Spine Number and Morphology in Prefrontal Cortex of Aged Female Rhesus Monkeys

Hao, J., Rapp, P. R., Leffler, A. E., Leffler, S. R., Janssen, W. G. M., Lou, W. Y. W., McKay, H. M., Roberts, J. A., Wearne, S. L., Hof, P. R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3440-05.2006 · Cited by 257 · see citing works

Repeated stress and structural plasticity in the brain

Radley, J. J., & Morrison, J. H. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.004 · Cited by 241 · see citing works

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

Wenk, G. L., Walker, L. C., Price, D. L., & Cork, L. C. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90047-n · Cited by 235 · see citing works

Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats.

Geinisman, Y., de Toledo‐Morrell, L., & Morrell, F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.3027 · Cited by 234 · see citing works

Age-related changes in multiple neurotransmitter systems in the monkey brain

Wenk, G. L., Pierce, D. J., Struble, R. G., Price, D. L., & Cork, L. C. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80005-3 · Cited by 222 · see citing works

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

Adams, M. M., Shah, R. A., Janssen, W. G. M., & Morrison, J. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141215898 · Cited by 222 · see citing works

Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex

Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0839-11.2011 · Cited by 219 · see citing works

Rapid modulation of long‐term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons

Mukai, H., Tsurugizawa, T., Murakami, G., Kominami, S., Ishii, H., Ogiue-Ikeda, M., Takata, N., Tanabe, N., Furukawa, A., Hojo, Y., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04264.x · Cited by 214 · see citing works

Estrogen Replacement Increases Spinophilin-immunoreactive Spine Number in the Prefrontal Cortex of Female Rhesus Monkeys

Tang, Y. C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg121 · Cited by 197 · see citing works

Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology

Calabrese, B., & Halpain, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.027 · Cited by 187 · see citing works

Interactive Effects of Stress and Aging on Structural Plasticity in the Prefrontal Cortex

Bloss, E. B., Janssen, W. G. M., McEwen, B. S., & Morrison, J. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0759-10.2010 · Cited by 185 · see citing works

Aging in the Rhesus Monkey: Effects on Visual Discrimination Learning and Reversal Learning

Bartus, R. T., Dean, R. L., & Fleming, D. L. (1979) · Journal of Gerontology · doi:10.1093/geronj/34.2.209 · Cited by 185 · see citing works

Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis

Wu, C. F., Bertorelli, R., Sacconi, M., Pepeu, G., & Consolo, S. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80081-2 · Cited by 183 · see citing works

Aged Rats Are Impaired on an Attentional Set-Shifting Task Sensitive to Medial Frontal Cortex Damage in Young RatsPreprint

Barense, M. D., Fox, M. T., & Baxter, M. G. (2002) · Learning & Memory · doi:10.1101/lm.48602 · Cited by 183 · see citing works

Layer‐specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex

de Brabander, Kramers, & Uylings (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00137.x · Cited by 180 · see citing works

Executive system dysfunction in the aged monkey: Spatial and object reversal learning

Lai, Z. C., Moss, M. B., Killiany, R., Rosene, D. L., & Herndon, J. G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02014-4 · Cited by 178 · see citing works

Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys.

Gazzaley, A. H., Siegel, S. J., Kordower, J. H., Mufson, E. J., & Morrison, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3121 · Cited by 177 · see citing works

Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex

Hao, J., Rapp, P. R., Janssen, W. G. M., Lou, W. Y. W., Lasley, B. L., Hof, P. R., & Morrison, J. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704757104 · Cited by 176 · see citing works

The effects of aging on layer 1 in area 46 of prefrontal cortex in the rhesus monkey

Peters, A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.8.671 · Cited by 167 · see citing works

Dynamic network connectivity: a new form of neuroplasticity

Arnsten, A. F. T., Paspalas, C. D., Gamo, N. J., Yang, Y., & Wang, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.003 · Cited by 160 · see citing works

Neuropsychological and neurophysiological changes in healthy adult humans across the age range

Albert, M. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90049-h · Cited by 158 · see citing works

Age-related changes in prefrontal cortex of Macaca mulatta: Quantitative analysis of dendritic branching patterns

Cupp, C. J., & Uemura, E. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90150-8 · Cited by 155 · see citing works

Age related changes in emotional memory.

Leigland, L. A., Schulz, L., & Janowsky, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.10.015 · Cited by 151 · see citing works

Effects of dendritic morphology on CA3 pyramidal cell electrophysiology: a simulation study

Krichmar, J. L., Nasuto, S. J., Scorcioni, R., Washington, S. D., & Ascoli, G. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02488-5 · Cited by 150 · see citing works

Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy

Cabello, C. R., Thune, J. J., Pakkenberg, H., & Pakkenberg, B. (2002) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2002.00393.x · Cited by 150 · see citing works

Animal models of prefrontal-executive function

Chudasama, Y. (2011) · Behavioral Neuroscience · doi:10.1037/a0023766 · Cited by 149 · see citing works

Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats

Colombo, P. J., Wetsel, W. C., & Gallagher, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14195 · Cited by 147 · see citing works

Recognition memory deficits in a subpopulation of aged monkeys resemble the effects of medial temporal lobe damage

Rapp, P. R., & Amaral, D. G. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90077-w · Cited by 144 · see citing works

Senescent microstructural changes in rat cerebellum

Rogers, J., Zornetzer, S. F., Bloom, F. E., & Mervis, R. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)90886-2 · Cited by 144 · see citing works

Differential effects and rates of normal aging in cerebellum and hippocampus

Woodruff-Pak, D. S., Foy, M. R., Akopian, G. G., Lee, K. H., Zach, J., Nguyen, K. P. T., Comalli, D. M., Kennard, J. A., Agelan, A., & Thompson, R. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914207107 · Cited by 143 · see citing works

Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex

Luebke, J. I., Chang, Y., Moore, T. L., & Rosene, D. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.035 · Cited by 142 · see citing works

Executive system dysfunction occurs as early as middle-age in the rhesus monkey

Moore, T. L., Killiany, R., Herndon, J. G., Rosene, D. L., & Moss, M. B. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.004 · Cited by 141 · see citing works

Age-related changes of pyramidal cell basal dendrites in layers III and V of human motor cortex: A quantitative Golgi study

Nakamura, S., Akiguchi, I., Kameyama, M., & Mizuno, N. (1985) · Acta Neuropathologica · doi:10.1007/bf00687009 · Cited by 139 · see citing works

Increased Action Potential Firing Rates of Layer 2/3 Pyramidal Cells in the Prefrontal Cortex are Significantly Related to Cognitive Performance in Aged Monkeys

Chang, Y. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh144 · Cited by 139 · see citing works

Impairment in abstraction and set shifting in aged Rhesus monkeys

Moore, T. L. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00054-4 · Cited by 137 · see citing works

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Hara, Y., Rapp, P. R., & Morrison, J. H. (2011) · AGE · doi:10.1007/s11357-011-9278-5 · Cited by 130 · see citing works

Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models

Luebke, J. I., Weaver, C. M., Rocher, A. B., Rodriguez, A., Crimins, J. L., Dickstein, D. L., Wearne, S. L., & Hof, P. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0244-2 · Cited by 113 · see citing works

Visual discrimination and reversal learning in the aged monkey (Macaca mulatta).

Rapp, P. R. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.6.876 · Cited by 112 · see citing works

Sexually dimorphic aging of dendritic morphology in CA1 of hippocampus

Markham, J. A., McKian, K. P., Stroup, T. S., & Juraska, J. M. (2004) · Hippocampus · doi:10.1002/hipo.20034 · Cited by 112 · see citing works

Influence of Highly Distinctive Structural Properties on the Excitability of Pyramidal Neurons in Monkey Visual and Prefrontal Cortices

Amatrudo, J. M., Weaver, C. M., Crimins, J. L., Hof, P. R., Rosene, D. L., & Luebke, J. I. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2581-12.2012 · Cited by 111 · see citing works

Integration of Cognitive and Motivational Context Information in the Primate Prefrontal Cortex

Watanabe, M., & Sakagami, M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm067 · Cited by 107 · see citing works

Morphological alterations in neurons forming corticocortical projections in the neocortex of aged Patas monkeys

Page, T. L., Einstein, M. C., Duan, H., He, Y., Flores, T., Rolshud, D., ERWIN, J. M., Wearne, S. L., Morrison, J. H., & Hof, P. R. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02428-4 · Cited by 104 · see citing works

Visual discrimination and reversal learning in the aged monkey (Macaca mulatta).

Rapp, P. R. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.6.876 · Cited by 103 · see citing works

The Electrotonic Structure of Pyramidal Neurons Contributing to Prefrontal Cortical Circuits in Macaque Monkeys Is Significantly Altered in Aging

Kabaso, D., Coskren, P. J., Henry, B. I., Hof, P. R., & Wearne, S. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn242 · Cited by 98 · see citing works

Dendritic processing

Segev, I. (1998) · Cited by 98 · see citing works

Impairments in acquisition and reversals of two-choice discriminations by aged rhesus monkeys

Voytko, M. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00097-4 · Cited by 97 · see citing works

Loss of Synapses in the Cerebellar Cortex of the Senescent Rat

Glick, R. P., & Bondareff, W. (1979) · Journal of Gerontology · doi:10.1093/geronj/34.6.818 · Cited by 96 · see citing works

The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.

Steere, J. C., & Arnsten, A. F. T. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.5.883 · Cited by 94 · see citing works

The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys.

Steere, J. C., & Arnsten, A. F. T. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.5.883 · Cited by 94 · see citing works

Aging of the Planning process: The role of executive functioning

Sorel, O., & Pennequin, V. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.07.006 · Cited by 87 · see citing works

Age-related changes in GluR2 and NMDAR1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys

Hof, P. R., Duan, H., Page, T. L., Einstein, M. C., Wicinski, B. A., He, Y., ERWIN, J. M., & Morrison, J. H. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03345-5 · Cited by 85 · see citing works

Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats

Pyapali, G. K., & Turner, D. A. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00034-6 · Cited by 85 · see citing works

Chapter 31 Chapter Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease

Flood, D. G., & Coleman, P. D. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)61267-4 · Cited by 82 · see citing works

Neuronal Firing Sensitivity to Morphologic and Active Membrane Parameters

Weaver, C. M., & Wearne, S. L. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0040011 · Cited by 79 · see citing works

Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex

Moore, T. L., Schettler, S. P., Killiany, R., Herndon, J. G., Luebke, J. I., Moss, M. B., & Rosene, D. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.12.003 · Cited by 79 · see citing works

Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis

Shi, L., Adams, M. M., Linville, M. C., Newton, I. G., Forbes, M. E., Long, A. B., Riddle, D. R., & Brunso‐Bechtold, J. K. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.026 · Cited by 78 · see citing works

Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys

Hara, Y., Park, C. S., Janssen, W. G. M., Roberts, M. T., Morrison, J. H., & Rapp, P. R. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.09.014 · Cited by 78 · see citing works

The Effects of Aging on Layer 1 of Primary Visual Cortex in the Rhesus Monkey

Peters, A. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.2.93 · Cited by 77 · see citing works

Protein kinase C activity, translocation, and conventional isoforms in aging rat brain

Battaini, F., Elkabes, S., Bergamaschi, S., Ladisa, V., Lucchi, L., Graan, P. N. E. D., Schuurman, T., Wetsel, W. C., Trabucchi, M., & Govoni, S. M. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00154-5 · Cited by 76 · see citing works

Age-related changes of structures in cerebellar cortex of cat

Zhang, C., Hua, T., Zhu, Z., & Luo, X. (2006) · Journal of Biosciences · doi:10.1007/bf02705235 · Cited by 76 · see citing works

Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration

Shimada, A., Tsuzuki, M., Keino, H., Satoh, M., Chiba, Y., Saitoh, Y., & Hosokawa, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00632.x · Cited by 74 · see citing works

Mathematical modelling and numerical simulation of the morphological development of neurons

Graham, B. P., & Arjen Van Ooyen, B. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-s1-s9 · Cited by 73 · see citing works

Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging

Bailey, M. E., Wang, A. C., Hao, J., Janssen, W. G. M., Hara, Y., Dumitriu, D., Hof, P. R., & Morrison, J. H. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.045 · Cited by 72 · see citing works

The Frontal Hypothesis of Cognitive Aging: Factor Structure and Age Effects on Four Frontal Tests Among Healthy Individuals

Rodríguez‐Aranda, C., & Sundet, K. S. (2006) · The Journal of Genetic Psychology · doi:10.3200/gntp.167.3.269-287 · Cited by 71 · see citing works

Information Processes in the Primate Prefrontal Cortex in Relation to Working Memory Processes

Funahashi, S., & Takeda, K. (2002) · Reviews in the Neurosciences · doi:10.1515/revneuro.2002.13.4.313 · Cited by 68 · see citing works

Synaptic Distributions of GluA2 and PKMζ in the Monkey Dentate Gyrus and Their Relationships with Aging and Memory

Hara, Y., Punsoni, M., Yuk, F., Park, C. S., Janssen, W. G. M., Rapp, P. R., & Morrison, J. H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0605-12.2012 · Cited by 66 · see citing works

Structural alterations in neurons of aged canine neocortex: A Golgi study

Mervis, R. F. (1978) · Experimental Neurology · doi:10.1016/0014-4886(78)90065-1 · Cited by 65 · see citing works

Endogenous glutamate release from frontal cortex of adult and aged rats

DAWSONJR, R., Wallace, D. R., & Meldrum, M. J. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90002-x · Cited by 62 · see citing works

Age-related dendritic hypertrophy and sexual dimorphism in rat basolateral amygdala

Rubinow, M. J., Drogos, L. L., & Juraska, J. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.006 · Cited by 61 · see citing works

Individual differences in spatial memory among aged rats are related to hippocampal PKCγ immunoreactivity

Colombo, P. J., & Gallagher, M. (2002) · Hippocampus · doi:10.1002/hipo.10016 · Cited by 57 · see citing works

Dendritic processing

Euler, T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00228-2 · Cited by 56 · see citing works

Differential effects of protein kinase inhibitors and activators on memory formation in the 2-day-old chick

Serrano, P. A., Beniston, D. S., Oxonian, M. G., Rodriguez, W. A., Rosenzweig, M. R., & Bennett, E. L. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80045-7 · Cited by 50 · see citing works

Effects of aging and caloric restriction on dentate gyrus synapses and glutamate receptor subunits

Newton, I. G., Forbes, M. E., Linville, M. C., Hui, P., Tucker, E. W., Riddle, D. R., & Brunso‐Bechtold, J. K. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.009 · Cited by 50 · see citing works

Regulation of phorbol ester binding and protein kinase C activity in aged rat brain

Battaini, F., Vesco, R. D., Govoni, S. M., & Trabucchi, M. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90118-j · Cited by 49 · see citing works

Quantitative morphology of medium-sized caudate spiny neurons in aged cats

Levine, M. S., Adinolfi, A. M., Fisher, R. S., Hull, C. D., Buchwald, N. A., & McAllister, J. P. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90008-4 · Cited by 49 · see citing works

Dying-back of Purkinje cell dendrites with synapse loss in aging rats

Chen, S., & Hillman, D. E. (1999) · Journal of Neurocytology · doi:10.1023/a:1007015721754 · Cited by 48 · see citing works

Effect of PKC inhibitors and activators on memory

Zhao, W., Sedman, G. L., Gibbs, M. E., & Ng, K. T. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90142-2 · Cited by 47 · see citing works

Protein kinase C activity is associated with prefrontal cortical decline in aging

Brennan, A. R., Yuan, P., Dickstein, D. L., Rocher, A. B., Hof, P. R., Manji, H. K., & Arnsten, A. F. T. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.020 · Cited by 47 · see citing works

Neurotransmitters in neocortex of aged rhesus monkeys

Beal, M. F., Walker, L. C., Storey, E., Segar, L., Price, D. L., & Cork, L. C. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90065-r · Cited by 44 · see citing works

The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice

Mathis, C., Lehmann, J. C., & Ungerer, A. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90020-5 · Cited by 40 · see citing works

Dendritic spines in the posterodorsal medial amygdala after restraint stress and ageing in rats

Marcuzzo, S., Dall’Oglio, A., Ribeiro, M. F. M., Achaval, M., & Rasia‐Filho, A. A. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.019 · Cited by 40 · see citing works

Spatial orienting of attention in adult and aged rhesus monkeys.

Baxter, M. G., & Voytko, M. L. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.5.898 · Cited by 38 · see citing works

Cortical neuropathological and neurochemical substrates of Alzheimer's and Parkinson's diseases.

Perry, R. H., Perry, E. K., Smith, C. J., Xuereb, J. H., Irving, D., Whitford, C. A., Candy, J. M., & Cross, A. J. (1987) · PubMed · Cited by 35 · see citing works

Age-related synapse loss in hippocampal CA3 is not reversed by caloric restriction

Adams, M. M., Donohue, H. S., Linville, M. C., Iversen, E., Newton, I. G., & Brunso-Bechtold, J. K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.022 · Cited by 34 · see citing works

Evidence for nonrandom regression of dendrites of Purkinje neurons during aging

Quackenbush, L. J., Ngo, H., & Pentney, R. J. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90043-y · Cited by 30 · see citing works

Spatial orienting of attention in adult and aged rhesus monkeys.

Baxter, M. G., & Voytko, M. L. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.5.898 · Cited by 30 · see citing works

Neuronal Changes in the Substantia Nigra with Aging

Cruz-Sánchez, F. F., Cardozo, A., & Tolosa, E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199501000-00009 · Cited by 29 · see citing works

Conversion of glucose to neurotransmitter amino acids in the brains of young and aging rats

Tyce, G. M., & Wong, K. (1980) · Experimental Gerontology · doi:10.1016/0531-5565(80)90005-4 · Cited by 27 · see citing works

Protein kinase C activation facilitates memory retention in rats.

Yang, H., & Lee, E. H. Y. (1993) · PubMed · Cited by 17 · see citing works

Age-Related Changes in the Synapses of the Rat' Neostriatum

Itzev, D. E., Lolova, I. S., Lolov, S. R., & Usunoff, K. G. (2001) · Archives of Physiology and Biochemistry · doi:10.1076/apab.109.1.80.4279 · Cited by 15 · see citing works

Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity.

Hanada, K., Katoh, H., Hosokawa, T., Hosono, M., & Takeda, T. (1991) · PubMed Central · Cited by 11 · see citing works

Aging and synaptic changes in the paraventricular hypothalamic nucleus of the rat.

Itzev, D. E., Lolov, S. R., & Usunoff, K. G. (2003) · PubMed · Cited by 6 · see citing works

Untitled work

(1997) · doi:10.1002/(sici)1096-9861(19971006)386:4

Epigenetic regulation of brain region-specific microglia clearance activity

Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460 · see citing works

A synopsis on aging—Theories, mechanisms and future prospects

da Costa, J. P., Vitorino, R. M. P., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha‐Santos, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.005 · Cited by 486 · see citing works

Roles of microglia in brain development, tissue maintenance and repair

Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works

Cellular senescence in brain aging

Sikora, E., Bielak-Zmijewska, A., Dudkowska, M., Krzystyniak, A., Mosieniak, G., Wesierska, M., & Wlodarczyk, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646924 · Cited by 304 · see citing works

Normal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes

Lee, J., & Kim, H.-J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931536 · Cited by 310 · see citing works

When pain gets stuck: the evolution of pain chronification and treatment resistance

Borsook, D., Youssef, A. M., Simons, L., Elman, I., & Eccleston, C. (2018) · Pain · doi:10.1097/j.pain.0000000000001401 · Cited by 281 · see citing works

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

Sun, S., Zhang, H., Liu, J., Александровна, П. Е., Xu, N., Feske, S., White, C. L., & Борисович, Б. И. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.019 · Cited by 273 · see citing works

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works

Brain aging mechanisms with mechanical manifestations

Blinkouskaya, Y., Caçoilo, A., Gollamudi, T., Jalalian, S., & Weickenmeier, J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111575 · Cited by 274 · see citing works

Dendritic spines: Revisiting the physiological role

Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 255 · see citing works

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Kelmer Sacramento, E., Kirkpatrick, J. M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209596 · Cited by 236 · see citing works

Cranial irradiation compromises neuronal architecture in the hippocampus

Parihar, V. K., & Limoli, C. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307301110 · Cited by 240 · see citing works

Dendritic Spine Plasticity: Function and Mechanisms

Runge, K., Cardoso, C., & de Chevigny, A. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00036 · Cited by 224 · see citing works

The Concept of Successful Aging: A Review Article

Estebsari, F., Dastoorpoor, M., Kandi, Z. R. K., Nouri, A., Mostafaei, D., Hosseini, M., Esmaeili, R., & Aghababaeian, H. (2019) · Current Aging Science · doi:10.2174/1874609812666191023130117 · Cited by 211 · see citing works

Impact of aging brain circuits on cognition

Samson, R. D., & Barnes, C. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12183 · Cited by 184 · see citing works

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

Nguyen, L. D., & Ehrlich, B. E. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012075 · Cited by 176 · see citing works

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works

Functional Consequences of Neurite Orientation Dispersion and Density in Humans across the Adult Lifespan

Nazeri, A., Chakravarty, M. M., Rotenberg, D. J., Rajji, T. K., Rathi, Y., Michailovich, O. V., & Voineskos, A. N. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3979-14.2015 · Cited by 162 · see citing works

BDNF signaling during the lifetime of dendritic spines

Zagrebelsky, M., Tacke, C., & Korte, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03226-5 · Cited by 147 · see citing works

Functional Magnetic Resonance Spectroscopy: The “New” MRS for Cognitive Neuroscience and Psychiatry Research

Stanley, J. A., & Raz, N. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00076 · Cited by 141 · see citing works

Aging in the olfactory system

Mobley, A. S., Rodriguez‐Gil, D. J., Imamura, F., & Greer, C. A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.004 · Cited by 140 · see citing works

Frontal Structural Neural Correlates of Working Memory Performance in Older Adults

Nissim, N. R., O’Shea, A. M., Bryant, V. E., Porges, E. C., Cohen, R. A., & Woods, A. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00328 · Cited by 135 · see citing works

Common Mechanisms of Alzheimer's Disease and Ischemic Stroke: The Role of Protein Kinase C in the Progression of Age-Related Neurodegeneration

Lucke-Wold, B. P., Turner, R. C., Logsdon, A. F., Simpkins, J. W., Alkon, D. L., Smith, K. E., Chen, Y., Tan, Z. T., Huber, J. D., & Rosen, C. L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141422 · Cited by 112 · see citing works

The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb

Reshef, R., Kudryavitskaya, E., Shani-Narkiss, H., Isaacson, B., Rimmerman, N., Mizrahi, A., & Yirmiya, R. (2017) · eLife · doi:10.7554/elife.30809 · Cited by 108 · see citing works

Brain Shape Changes Associated With Cerebral Atrophy in Healthy Aging and Alzheimer’s Disease

Blinkouskaya, Y., & Weickenmeier, J. (2021) · Frontiers in Mechanical Engineering · doi:10.3389/fmech.2021.705653 · Cited by 109 · see citing works

Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies

Agnès Lacreuse, A., Raz, N., Schmidtke, D., Hopkins, W. D., & Herndon, J. G. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0618 · Cited by 101 · see citing works

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging

Cabral‐Miranda, F., Tamburini, G., Martínez, G., Ardiles, Á. O., Medinas, D. B., Gerakis, Y., Hung, M.-L. D., Vidal, R. L., Fuentealba, M., Miedema, T., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022111952 · Cited by 95 · see citing works

Species and cell-type properties of classically defined human and rodent neurons and glia

Xu, X., Stoyanova, E. I., Patriotis, A. L., Xing, J., Mash, D. C., & Heintz, N. (2018) · eLife · doi:10.7554/elife.37551 · Cited by 90 · see citing works

Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid

Henderson, B. W., Greathouse, K. M., Ramdas, R., Walker, C. K., Rao, T. C., Bach, S. V., Curtis, K. A., Day, J. J., Mattheyses, A. L., & Herskowitz, J. H. (2019) · Science Signaling · doi:10.1126/scisignal.aaw9318 · Cited by 92 · see citing works

Predicting age from cortical structure across the lifespan

Madan, C. R., & Kensinger, E. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13835 · Cited by 91 · see citing works

Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging

Boros, B. D., Greathouse, K. M., Gearing, M., & Herskowitz, J. H. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.003 · Cited by 90 · see citing works

Jaw sensorimotor control in healthy adults and effects of ageing

Avivi‐Arber, L., & Sessle, B. J. (2017) · Journal of Oral Rehabilitation · doi:10.1111/joor.12554 · Cited by 91 · see citing works

Structural Plasticity of the Hippocampus in Neurodegenerative Diseases

Weerasinghe-Mudiyanselage, P. D. E., Ang, M. J., Kang, S., Kim, J., & Moon, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063349 · Cited by 95 · see citing works

Roles for neuronal and glial autophagy in synaptic pruning during development

Lieberman, O. J., McGuirt, A. F., Tang, G., & Sulzer, D. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.04.017 · Cited by 87 · see citing works

Automatic Dendritic Spine Quantification from Confocal Data with Neurolucida 360

Dickstein, D. L., Dickstein, D. R., Janssen, W. G. M., Hof, P. R., Glaser, J. R., Rodriguez, A., O'Connor, N., Angstman, P. J., & Tappan, S. J. (2016) · Current Protocols in Neuroscience · doi:10.1002/cpns.16 · Cited by 83 · see citing works

Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?

Queen, N. J., Hassan, Q. N., & Cao, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00605 · Cited by 84 · see citing works

Inflammaging and Brain Aging

Jurcău, M. C., Jurcău, A., Cristian, A., Hogea, V. O., Diaconu, R. G., & Nunkoo, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910535 · Cited by 90 · see citing works

Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging

Merluzzi, A. P., Dean, D. C., Adluru, N., Suryawanshi, G. S., Okonkwo, O. C., Oh, J. M., Hermann, B. P., Sager, M. A., Asthana, S., Zhang, H., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.026 · Cited by 78 · see citing works

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Liu, J., Supnet, C. B., Sun, S., Zhang, H., Good, L. B., Александровна, П. Е., & Борисович, Б. И. (2014) · Channels · doi:10.4161/chan.27471 · Cited by 77 · see citing works

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice

Qu, W., & Li, L. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2193-20.2020 · Cited by 70 · see citing works

The Cognitive Effects of Radiotherapy for Brain Metastases

Lehrer, E. J., Jones, B. M., Dickstein, D. R., Green, S., Germano, I. M., Palmer, J. D., Laack, N. N., Brown, P. D., Gondi, V., Wefel, J. S., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.893264 · Cited by 70 · see citing works

The effects of aging on neuropil structure in mouse somatosensory cortex—A 3D electron microscopy analysis of layer 1

Calì, C., Wawrzyniak, M., Becker, C., Maco, B., Cantoni, M., Jorstad, A., Nigro, B., Grillo, F. W., Paola, V. D., Fua, P., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198131 · Cited by 63 · see citing works

Age-Related Changes to Layer 3 Pyramidal Cells in the Rhesus Monkey Visual Cortex

Luebke, J. I., Medalla, M., Amatrudo, J. M., Weaver, C. M., Crimins, J. L., Hunt, B. A. E., Hof, P. R., & Peters, A. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht336 · Cited by 68 · see citing works

Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity

Gupta, S. C., Yadav, R., Pavuluri, R., Morley, B. J., Stairs, D. J., & Dravid, S. M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.013 · Cited by 65 · see citing works

Cognitive training can reduce the rate of cognitive aging: a neuroimaging cohort study

Li, T., Yao, Y., Cheng, Y., Xu, B., Cao, X., Waxman, D., Feng, W., Shen, Y., Li, Q., Wang, J., et al. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0194-5 · Cited by 59 · see citing works

Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats

Lauterborn, J. C., Palmer, L. C., Jia, Y., Pham, D. T., Hou, B., Wang, W., Trieu, B. H., Cox, C. D., Kantorovich, S., Gall, C. M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3157-15.2016 · Cited by 61 · see citing works

Biochemical deficits and cognitive decline in brain aging: Intervention by dietary supplements

Poddar, J., Pradhan, M., Ganguly, G., & Chakrabarti, S. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.04.002 · Cited by 62 · see citing works

Beneficial effects of dietary restriction in aging brain

Hadem, I. K. H., Majaw, T., Kharbuli, B., & Sharma, R. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.001 · Cited by 59 · see citing works

Synaptic plasticity at the interface of health and disease: New insights on the role of endoplasmic reticulum intracellular calcium stores

Maggio, N., & Vlachos, A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.041 · Cited by 57 · see citing works

Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss

Burrinha, T., Martinsson, I., Gomes, R. A., Terrasso, A. P., Gouras, G. K., & Almeida, C. G. (2021) · Journal of Cell Science · doi:10.1242/jcs.255752 · Cited by 56 · see citing works

Key periods of cognitive decline in a nonhuman primate model of cognitive aging, the common marmoset (Callithrix jacchus)

Sadoun, A., Rosito, M., Fonta, C., & Girard, P. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.003 · Cited by 52 · see citing works

Adrenocortical Status Predicts the Degree of Age-Related Deficits in Prefrontal Structural Plasticity and Working Memory

Anderson, R. M., Birnie, A. K., Koblesky, N. K., Romig‐Martin, S. A., & Radley, J. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1385-14.2014 · Cited by 51 · see citing works

Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism

Musto, A., Rosencrans, R. F., Walker, C. P., Bhattacharjee, S., Raulji, C. M., Belayev, L., Fang, Z., Gordon, W., & Bazan, N. (2016) · Scientific Reports · doi:10.1038/srep30298 · Cited by 48 · see citing works

Neuronal Senescence in the Aged Brain

Chou, S.-M., Yen, Y., Yuan, F., Zhang, S., & Chong, C. (2023) · Aging and Disease · doi:10.14336/ad.2023.0214 · Cited by 54 · see citing works

Interneuron Simplification and Loss of Structural Plasticity As Markers of Aging-Related Functional Decline

Eavri, R., Shepherd, J. D., Welsh, C. A., Flanders, G. H., Bear, M. F., & Nedivi, E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0808-18.2018 · Cited by 49 · see citing works

BACE1 controls synaptic function through modulating release of synaptic vesicles

Das, B., Singh, N., Yao, A. Y., Zhou, J., He, W., Hu, X., & Yan, R. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01166-2 · Cited by 49 · see citing works

Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Tian, R., Zhang, Y., Pan, Q., Wang, Y., Wen, Q., Fan, X., Qin, G., Zhang, D., Chen, L., Zhang, Y., et al. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01403-1 · Cited by 47 · see citing works

Structural and molecular correlates of cognitive aging in the rat

Mota, C., Taipa, R. J. F., das Neves, S. P., Monteiro-Martins, S., Monteiro, S., Palha, J. A., Sousa, N., Sousa, J. C., & Cerqueira, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39645-w · Cited by 46 · see citing works

Age- and memory- related differences in hippocampal gray matter integrity are better captured by NODDI compared to single-tensor diffusion imaging

Venkatesh, A., Stark, S. M., Stark, C. E. L., & Bennett, I. J. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.08.004 · Cited by 45 · see citing works

Interneuron Deficit Associates Attenuated Network Synchronization to Mismatch of Energy Supply and Demand in Aging Mouse Brains

Jessen, S. B., Mathiesen, C., Lind, B. L., & Lauritzen, M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv261 · Cited by 48 · see citing works

Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex

Coskren, P. J., Luebke, J. I., Kabaso, D., Wearne, S. L., Yadav, A., Rumbell, T. H., Hof, P. R., & Weaver, C. M. (2014) · Journal of Computational Neuroscience · doi:10.1007/s10827-014-0541-5 · Cited by 45 · see citing works

Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamsters

Bullmann, T., Seeger, G., Stieler, J., Hanics, J., Reimann, K., Kretzschmann, T. P., Hilbrich, I., Holzer, M., Alpár, A., & Arendt, T. (2015) · Hippocampus · doi:10.1002/hipo.22522 · Cited by 46 · see citing works

Age‐related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset

Madan, C. R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15039 · Cited by 44 · see citing works

The endocrine-brain-aging triad where many paths meet: female reproductive hormone changes at midlife and their influence on circuits important for learning and memory

Koebele, S. V., & Bimonte‐Nelson, H. A. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.011 · Cited by 43 · see citing works

Transcranial direct current stimulation decreased cognition-related reaction time in older adults: A systematic review and meta-analysis

Lee, J. H., Lee, T. L., & Kang, N. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101377 · Cited by 43 · see citing works

Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging

Devi, S. A., & Chamoli, A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_7 · Cited by 41 · see citing works

Effects of Transcranial Direct Current Stimulation (tDCS) on Cognitive Performance and Cerebral Oxygen Hemodynamics: A Systematic Review

Figeys, M., Zeeman, M., & Kim, E. S. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.623315 · Cited by 42 · see citing works

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia

Ouellette, A. R., Neuner, S. M., Dumitrescu, L. C., Anderson, L. C., Gatti, D. M., Mahoney, E. R., Bubier, J. A., Churchill, G. A., Peters, L. L., Huentelman, M. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108091 · Cited by 40 · see citing works

Deacidification of endolysosomes by neuronal aging drives synapse loss

Burrinha, T., Cunha, C., Hall, M. J., Lopes‐da‐Silva, M., Seabra, M. C., & Guimas Almeida, C. (2023) · Traffic · doi:10.1111/tra.12889 · Cited by 35 · see citing works

Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation

Prévot, T. D., Sumitomo, A., Tomoda, T., Knutson, D. E., Li, G., Mondal, P., Banasr, M., Cook, J. M., & Sibille, E. L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa310 · Cited by 38 · see citing works

Noise-induced auditory damage affects hippocampus causing memory deficits in a model of early age-related hearing loss

Paciello, F., Pisani, A., Rinaudo, M., Cocco, S., Paludetti, G., Fetoni, A. R., & Grassi, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106024 · Cited by 37 · see citing works

Towards Combinatorial Approaches for Preserving Cognitive Fitness in Aging

Brem, A., & Sensi, S. L. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.09.009 · Cited by 37 · see citing works

On the relationship between cellular and hemodynamic properties of the human brain cortex throughout adult lifespan

Zhao, Y., Wen, J., Cross, A. H., & Yablonskiy, D. A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.022 · Cited by 35 · see citing works

Nuclear Calcium Buffering Capacity Shapes Neuronal Architecture

Mauceri, D., Hagenston, A. M., Schramm, K., Weiss, U. K., & Bading, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.654962 · Cited by 36 · see citing works

Sex-specific features of spine densities in the hippocampus

Brandt, N., Löffler, T., Fester, L., & Rune, G. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-68371-x · Cited by 36 · see citing works

Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus

Amani, M., Lauterborn, J. C., Le, A. A., Cox, B. M., Wang, W., Quintanilla, J., Cox, C. D., Gall, C. M., & LYNCH, G. S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2376-20.2021 · Cited by 35 · see citing works

Age-dependent changes in the medial prefrontal cortex and medial amygdala structure, and elevated plus-maze performance in the healthy male Wistar rats

Sotoudeh, N., Namavar, M. R., Zarifkar, A., & Heidarzadegan, A. R. (2020) · IBRO Reports · doi:10.1016/j.ibror.2020.08.002 · Cited by 34 · see citing works

Irradiation of Neurons with High-Energy Charged Particles: An In Silico Modeling Approach

Alp, M., Parihar, V. K., Limoli, C. L., & Cucinotta, F. A. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004428 · Cited by 33 · see citing works

Structural Analysis of Human and Mouse Dendritic Spines Reveals a Morphological Continuum and Differences across Ages and Species

Ofer, N., Benavides‐Piccione, R., DeFelipe, J., & Yuste, R. (2022) · eNeuro · doi:10.1523/eneuro.0039-22.2022 · Cited by 30 · see citing works

Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery

Prior, M., Goldberg, J., Chiruta, C., Farrokhi, C. B., Kopynets, M., Roberts, A. J., & Schubert, D. A. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.03.016 · Cited by 32 · see citing works

Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition

Lubec, J., Kalaba, P., Hussein, A. M., Feyissa, D. D., Kotob, M. H., Mahmmoud, R. R., Wieder, O., Garon, A., Sagheddu, C., Ilic, M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01214-x · Cited by 31 · see citing works

Changes in the plastic properties of hippocampal dendritic spines underlie the attenuation of place learning in healthy aged rats

González-Ramírez, M. M., Velázquez-Zamora, D. A., Olvera‐Cortés, M. E., & González‐Burgos, I. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.017 · Cited by 32 · see citing works

Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders

Barrantes, F. J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1476909 · Cited by 31 · see citing works

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

Machiela, E., Jeloka, R., Caron, N. S., Mehta, S., Schmidt, M. E., Baddeley, H. J. E., Tom, C. M., Polturi, N., Xie, Y., Mattis, V. B., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.524369 · Cited by 29 · see citing works

Neurite Imaging Reveals Widespread Alterations in Gray and White Matter Neurite Morphology in Healthy Aging and Amnestic Mild Cognitive Impairment

Gozdas, E., Fingerhut, H., Dacorro, L., Bruno, J. L., & Hosseini, S. M. H. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab180 · Cited by 30 · see citing works

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Augustin, H., McGourty, K., Allen, M. J., Kudumala, S., Adcott, J., Kerr, F., Wong, C. T., Vincent, A. J., Godenschwege, T. A., Boucrot, E., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2001655 · Cited by 30 · see citing works

Effect of ozone exposure on dendritic spines of CA1 pyramidal neurons of the dorsal hippocampus and on object-place recognition memory in rats

Bello-Medina, P. C., Prado-Alcalá, R. A., & Rivas-Arancibia, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.018 · Cited by 29 · see citing works

CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice

Latorre‐Leal, M., Rodriguez‐Rodriguez, P., Franchini, L., Nikolidakis, O., Daniilidou, M., Delac, L., Varshney, M., Arroyo‐García, L. E., Eroli, F., Winblad, B. G., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj1354 · Cited by 30 · see citing works

Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

Parajuli, L. K., Wako, K., Maruo, S., Kakuta, S., Taguchi, T., Ikuno, M., Yamakado, H., Takahashi, R., & Koike, M. (2020) · eNeuro · doi:10.1523/eneuro.0072-20.2020 · Cited by 29 · see citing works

Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration

Collier, T. J., O’Malley, J. A., Rademacher, D. J., Stancati, J. A., Sisson, K. A., Sortwell, C. E., Paumier, K. L., Gebremedhin, K. G., & Steece‐Collier, K. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.005 · Cited by 27 · see citing works

The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review

Vandersmissen, J., Dewachter, I., Cuypers, K., & Hansen, D. (2025) · Sports Medicine - Open · doi:10.1186/s40798-025-00836-7 · Cited by 26 · see citing works

Sex‐dependency of oestrogen‐induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents

Brandt, N., & Rune, G. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14541 · Cited by 26 · see citing works

Normal ageing of the brain: Histological and biological aspects

Teissier, T., Boulanger, É., & Deramecourt, V. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.03.017 · Cited by 27 · see citing works

Neuronal microstructural changes in the human brain are associated with neurocognitive aging

Singh, K., Barsoum, S., Schilling, K. G., An, Y., Ferrucci, L., & Benjamini, D. (2024) · Aging Cell · doi:10.1111/acel.14166 · Cited by 25 · see citing works

Unilateral injection of Aβ25–35in the hippocampus reduces the number of dendritic spines in hyperglycemic rats

Lazcano, Z., Solís, Ó., Bringas, M. E., Limón, I. D., Díaz, A., Espinosa, B., García‐Peláez, I., Flores, G., & Guevara, J. (2014) · Synapse · doi:10.1002/syn.21770 · Cited by 25 · see citing works

Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity

Albertson, A. J., Landsness, E., Tang, M. J., Yan, P., Miao, H.-Y., Rosenthal, Z., Kim, B., Culver, J. C., Bauer, A. Q., & Lee, J.-M. (2021) · bioRxiv · doi:10.1016/j.neuroimage.2022.119287 · Cited by 25 · see citing works

Age‐related alterations in human cortical microstructure across the lifespan: Insights from high‐gradient diffusion MRI

Lee, H., Lee, H., Ma, Y., Eskandarian, L., Gaudet, K., Tian, Q., Krijnen, E. A., Russo, A. W., Salat, D. H., Klawiter, E. C., et al. (2024) · Aging Cell · doi:10.1111/acel.14267 · Cited by 24 · see citing works

Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion

Bez, F., Francardo, V., & Cenci, M. A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.06.005 · Cited by 24 · see citing works

Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities

Hébert, J. M., & Vijg, J. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.02.008 · Cited by 24 · see citing works

Selective neuronal vulnerability in Alzheimer’s disease

Wang, Z.-T., Zhang, C. M., Wang, Y., Dong, Q., Tan, L., & Yu, J. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101114 · Cited by 24 · see citing works

Influence of aging and neurodegeneration on dendritic spine morphology

Bloss, E. B., Morrison, J. H., Hof, P. R., & Dickstein, D. L. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0008-3 · Cited by 12 · see citing works

Dendritic spine remodeling and aging

Boros, B. D., & Herskowitz, J. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00022-6

Morphological changes in nerve cells during normal aging

Pannese, E. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0308-y · Cited by 205 · see citing works

Changes in the structural complexity of the aged brain

Dickstein, D. L., Kabaso, D., Rocher, A. B., Luebke, J. I., Wearne, S. L., & Hof, P. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00289.x · Cited by 460 · see citing works

Plastic changes to dendritic spines in the cerebellar and prefrontal cortices underlie the decline in motor coordination and working memory during successful aging

Vázquez-Hernández, N., Martínez-Torres, N. I., & González‐Burgos, I. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113014 · Cited by 7 · see citing works