Negative cognitive style interacts with negative life events to predict first onset of a major depressive episode in adolescence via hopelessness
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The hopelessness theory of depression is a prominent account of depression that posits that individuals with a negative inferential style are more likely to become hopeless when they experience negative life events (NLEs) and that hopelessness is a proximal cause of depression. There is strong evidence supporting the role of a negative inferential style in the pathogenesis of major depression; however, substantially less is known about the proposed role played by hopelessness. The cornerstone hypothesis of hopelessness theory, that hopelessness is a proximal cause of major depression, is largely untested. A small number of studies have generated inconclusive evidence that hopelessness mediates the relationship between a negative inferential style, NLEs, and depressive symptoms. The current study tested whether hopelessness mediates the relationship between a Negative Inferential Style × NLEs interaction and (a) 1st onset of a major depressive episode (MDE) and (b) depressive symptoms in a fully prospective design. A diverse sample of 249 adolescents, ages 12-13 years, were assessed at baseline and at 2 or more follow-ups over approximately 2.5 years. Self-report as well as life event and diagnostic interviews assessed inferential style, NLEs, hopelessness, depressive symptoms, and depression diagnosis. Moderated mediation analyses indicated that hopelessness mediated the relationship between a Negative Inferential Style × NLEs interaction and (a) 1st onset of an MDE as well as (b) depressive symptoms at higher levels of multiple types of NLEs. The current study demonstrates the validity of the hopelessness theory of depression and its continued clinical relevance in predicting depression in adolescence. (PsycINFO Database Record
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Determinants related to depression include low self-esteem and shame.
“Determinants related to this condition include low self-esteem and shame, among other factors [269,270,275,278].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [275]
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Gene expression in peripheral blood in treatment-free major depression
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- Authors
- Mac Giollabhui, N., Hamilton, J. L., Nielsen, J., Connolly, S. L., Stange, J. P., Varga, S., Burdette, E., Olino, T. M., Abramson, L. Y., & Alloy, L. B.
- Affiliations
- Temple University (US)
- University of Illinois Chicago (US)
- University of Wisconsin–Madison (US)
- ORCID
- Venue
- Journal of Abnormal Psychology
- Published
- 2018-01
- Volume
- 127
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- PMC
- PMC5785411
- OpenAlex
- W2768978068
- Cited by
- 66
- References
- 55
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 4
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Abnormal Psychology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH079369 and MH101168, 5T32MH067631-12)
- Sponsor name not included (F31MH106184, F31MH106181, F31MH099761)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- hopelessness theory of depression, negative life events, adolescent depression, depressive symptoms, hopelessness, moderated mediation, depression prediction
- MeSH terms
- Adolescent, Child, Cognition, Major Depressive Disorder, Female, Humans, Life Change Events, Male, Psychiatric Status Rating Scales, Thinking
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