Cited by 11Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Research Topics

A Latent Structure Analysis of Cognitive Vulnerability to Depression in Adolescence

Open access
Liu, Richard T., McArthur, Brae Anne, Burke, Taylor A., Hamilton, Jessica L., Mac Giollabhui, Naoise, Stange, Jonathan P., Hamlat, Elissa J., Abramson, Lyn Y. +1 more·2019·Behavior Therapy

Abstract

Whether cognitive vulnerability to depression exists along a continuum of severity or as a qualitatively discrete phenomenological entity has direct bearing on theoretical formulations of risk for depression and clinical risk assessment. This question is of particular relevance to adolescence, given that cognitive vulnerability appears to coalesce and rates of depression begin to rise markedly during this period of development. Although a dimensional view is often assumed, it is necessary to submit this assumption to direct empirical evaluation. Taxometric analysis is a family of statistical techniques developed directly to test such assumptions. The present study applied taxometric methods to address this question in a community sample of early adolescents (n = 485), drawing on three indices of cognitive vulnerability to depression (i.e., negative inferential style, ruminative response style, self-referent information processing). The results of three taxometric analyses (i.e., mean above minus below a cut [MAMBAC], maximum eigenvalue [MAXEIG], and latent mode [L-Mode]) were consistent in unambiguously supporting a dimensional conceptualization of this construct. The latent structure of the tested indices of cognitive vulnerability to depression in adolescence appears to exist along a continuum of severity rather than as a discrete clinical entity.

AI snapshot

Written from the paper’s full text.

TL;DR

In a community sample of 485 early adolescents, three taxometric procedures consistently indicated that cognitive vulnerability to depression is dimensional rather than taxonic. The findings support a continuum-of-severity conceptualization and argue against a discrete clinical entity.

Key findings

  • MAMBAC, MAXEIG, and L-Mode all produced results more consistent with dimensional than taxonic latent structure for cognitive vulnerability to depression.
  • CCFI values were CCFI_MAMBAC = 0.237, CCFI_MAXEIG = 0.194, CCFI_L-Mode = 0.288, mean CCFI = 0.240, all near the dimensional end of the 0–1 scale.
  • Four indicators were retained: ACSQ-M globality-stability, ACSQ-M self-characteristics, CRSQ rumination, and SRET negative self-schema; mean full-sample inter-indicator r = 0.37, mean taxon/complement rs ≤ 0.06, and all indicators had d ≥ 1.25.
  • The authors conclude the results align with a titration model and imply that cut-points based on cognitive vulnerability are artificial and should be interpreted cautiously.

Methods

  • Community sample of 485 early adolescents (mean age = 12.86 years, SD = 0.59; 48.5% white, 52.4% female) from the baseline assessment of the Adolescent Cognition and Emotion Project; recruited via Philadelphia School District mailings (68%) and local newspaper advertisements (32%).
  • Measures included the ACSQ-M for negative inferential style, the CRSQ rumination subscale, and the behavioral Self-Referent Encoding Task (SRET) for negative self-schema and recall bias.
  • Taxometric analyses used MAMBAC, MAXEIG, and L-Mode with simulated taxonic and dimensional comparison data generated 100 times per model; the comparison curve fit index (CCFI) objectively compared empirical fit to each latent structure.

Limitations

  • The paper states that additional research is needed to generalize to all aspects of cognitive vulnerability to depression, including future examination of other markers such as cognitive control and overgeneral autobiographical memory, and additional methods such as neural indices.
  • Evident from the text: all data came from a single baseline assessment, so the latent-structure findings are cross-sectional.
  • Evident from the text: the sample was restricted to 12–13-year-olds, specific racial groups (white, African American/Black, or biracial), and adolescents with a participating mother/female primary caretaker; only four indicators were retained for analysis.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1016/j.beth.2018.11.004

Cites

59 of 60 references verified1 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 33 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    Cognitive vulnerability to depression exists along a continuum of severity.

    “Our findings that cognitive vulnerability to depression exists along a continuum of severity align well with this interpretation.”
    • Also stated in: § Discussion · plain
      “dimensional vulnerability factors such as articulated in the titration model and observed in the current study”
    • Also stated in: § Discussion · plain
      “A dimensional solution for the vulnerability construct”
    Quote in the paperSubstantial claim
  • Interpretationown data

    The latent structure of the tested indices of cognitive vulnerability to depression in adolescence is dimensional (exists along a continuum of severity) rather than taxonic or discrete.

    “The latent structure of the tested indices of cognitive vulnerability to depression in adolescence appears to exist along a continuum of severity rather than as a discrete clinical entity.”
    • Also stated in: § Discussion · boosted
      “Across three mathematically distinct taxometric procedures, and based on a combination of self-report and behavioral data, the current study found clear and consistent evidence of dimensionality in the latent structure of three indices of cognitive vulnerability to depression in a sample of early adolescents.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The findings from this community sample of early adolescents generalize to cognitive vulnerability to depression in adolescence more broadly.
  • Premisecitation

    Several taxometric studies of youth depression have yielded mixed support for a dimensional versus taxonic latent structure.

    “Several taxometric studies of youth depression have been conducted (e.g., Hankin, Fraley, Lahey, & Waldman, 2005; Liu, 2016; Richey et al., 2009; Solomon, Ruscio, Seeley, & Lewinsohn, 2006), with mixed support for a dimensional versus taxonic latent structure.”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites Hankin et al., 2005

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    • cites Liu, 2016 source

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    • cites Richey et al., 2009 source

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  • Study design and conductown data

    The ACSQ-M subscales had excellent internal consistency in this sample (αGlobality-Stability = .90, αConsequences = .86, αSelf-Characteristics = .88).

    “Internal consistency in this sample was excellent (αGlobality-Stability = .90, αConsequences =.86, αSelf-Characteristics =.88).”
    Quote in the paperNot a substantial claim
  • Interpretationreasoning

    It cannot be assumed that evidence of dimensionality in adults (Gibb et al., 2004) is generalizable to adolescents, given developmental differences in cognitive vulnerability.

    “Given developmental differences in cognitive vulnerability, it cannot be assumed that evidence of dimensionality in adults (Gibb et al., 2004) is generalizable to adolescents.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Gibb et al., 2004 source

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  • The quote only partly states this claim. 2
  • Classified as probably not a substantial claim. 17
  • May combine two claims. 9
  • The quote only partly states this claim.

    Findingown data

    The empirical data were consistent in more closely resembling the dimensional distributions than the simulated taxonic distributions across all three taxometric procedures.

    “The empirical data were consistent in more closely resembling the dimensional distributions.”
    Quote in the paperSubstantial claim
  • The quote only partly states this claim.

    Findingown data

    The three taxometric analyses (MAMBAC, MAXEIG, L-Mode) on the four retained indicators of cognitive vulnerability in 485 early adolescents yielded CCFI values that unambiguously favored dimensional solutions (CCFIMAMBAC = 0.237, CCFIMAXEIG = 0.194, CCFIL-Mode = 0.288, mean CCFI = 0.240).

    “The results of three taxometric analyses (i.e., mean above minus below a cut [MAMBAC], maximum eigenvalue [MAXEIG], and latent mode [L-Mode]) were consistent in unambiguously supporting a dimensional conceptualization of this construct.”
    • Also stated in: § Taxometric analyses · boosted
      “The corresponding CCFIs were similarly consistent in unambiguously favoring dimensional solutions (CCFIMAMBAC = 0.237, CCFIMAXEIG = 0.194, CCFIL-Mode = 0.288, mean CCFI = 0.240).”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    The CRSQ has demonstrated adequate validity in previous research.

    “The CRSQ has demonstrated adequate validity in previous research (Abela et al., 2004)”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Abela et al., 2004 source

      Not checked in the free run.

  • May combine two claims.

    Study design and conductown data

    All four indicators separated the putative taxon from its complement at Cohen's d ≥ 1.25, satisfying the recommended minimum validity.

    “This condition was satisfied in the current study (for all indicators, d ≥ 1.25)2.”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Meehl, 1995 source

      Not checked in the free run.

    • cites Meehl & Yonce, 1996

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  • May combine two claims.

    Premisecitation

    Only one taxometric study exists examining the latent structure of cognitive vulnerability to depression (Gibb et al., 2004), and it found evidence of dimensionality.

    “Yet, only one taxometric study exists examining the latent structure of cognitive vulnerability to depression (Gibb, Alloy, Abramson, Beevers, & Miller, 2004), finding evidence of dimensionality.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Gibb et al., 2004 source

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  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    The CCFI thresholds (0.45-0.55 for ambiguity) have accuracy rates of 98.2% for MAMBAC, 95.8% for MAXEIG, and 97.3% for L-Mode.

    “These dual thresholds have an accuracy rate of 98.2% for MAMBAC, 95.8% for MAXEIG, and 97.3% for L-Mode (Ruscio et al., 2010).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Ruscio et al., 2010

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    The CCFI is an objective index that differentiates taxonic and dimensional data with high accuracy and is robust to poor measurement conditions, supplanting subjective visual inspection of taxometric graphical output.

    “As an objective index for differentiating between taxonic and dimensional data at a high level of accuracy and being robust to a wide array of poor measurement conditions (Ruscio & Kaczetow, 2009), the CCFI supplants the approach adopted in older studies, which relied on subjective interpretation based on visual inspection of taxometric graphical output, which is more vulnerable to spurious taxon”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Ruscio & Kaczetow, 2009

      Not checked in the free run.

    • cites Haslam et al., 2012 source

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  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The CRSQ rumination subscale had an internal consistency of α = .85 in the current sample.

    “The CRSQ has demonstrated adequate validity in previous research (Abela et al., 2004), and α =.85 in the current sample.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Study design and conductown data

    For the four retained indicators, the mean full-sample inter-indicator correlation was 0.37 and the mean within-taxon and complement correlations were ≤ 0.06, satisfying the requirement for a sizeable difference between full-sample and within-group correlations.

    “Satisfying these requirements, for the four indicators, mean full sample r = 0.37 and mean taxon and complement rs ≤ 0.06.”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Meehl, 1995 source

      Not checked in the free run.

    • cites Ruscio et al., 2006

      Not checked in the free run.

  • Classified as probably not a substantial claim. May combine two claims.

    Premisereasoning

    Within a pure interaction framework, the dichotomous diathesis-stress interpretation implies that, in the absence of other vulnerabilities, cognitive vulnerability is a necessary condition for depression to manifest, and stress only exerts a deleterious influence in the presence of this diathesis.

    “Within a pure interaction framework, the implication of this interpretation is that, in the absence of other vulnerabilities, cognitive vulnerability is a necessary condition for depression to manifest, and stress only exerts a deleterious influence in the presence of this diathesis.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisereasoning

    The adoption of cut-points in high-risk studies is guided largely by practical considerations centering on feasibility and statistical power.

    “their adoption is guided largely by practical considerations centering on feasibility and statistical power.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).

    Interpretationreasoning

    Additional research is necessary to be able to generalize the current findings to all aspects of cognitive vulnerability to depression.

    “additional research is necessary to be able to generalize to all aspects of cognitive vulnerability to depression.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    The current findings do not necessarily indicate that cut-points should be avoided in the screening of risk.

    “The current findings do not necessarily indicate that cut-points should be avoided in the screening of risk.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationreasoning

    Dichotomizing individuals based on cognitive vulnerability creates largely artificial and arbitrary distinctions, including the cut-points used in high-risk studies.

    “A dimensional solution for the vulnerability construct, however, also points to the importance of recognizing that the cut-points used in such studies are artificial ones”
    • Also stated in: § Discussion · plain
      “any attempt to dichotomize individuals based on cognitive vulnerability creates largely artificial and arbitrary distinctions”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim.

    Premisecitation

    Several studies have obtained empirical support for the view that cognitive vulnerabilities transition from mediators to moderators of the relation between negative life events and depression.

    “Several studies have obtained empirical support for this view (Cole et al., 2001; Tram & Cole, 2000; Uhrlass & Gibb, 2007).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Cole et al., 2001 source

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    • cites Tram & Cole, 2000

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    • cites Uhrlass & Gibb, 2007

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  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    Assessments of therapeutic change in cognitive risk for depression may benefit from viewing this change as falling along a continuum rather than as a qualitatively distinct change from at risk to outside of risk.

    “the current findings suggest that assessments of therapeutic change in cognitive risk for depression may benefit from viewing this change as falling along a continuum rather than being characterized by a qualitatively distinct change from at risk to being outside of risk.”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim.

    Premisecitation

    The dichotomous diathesis-stress model holds that the vulnerability factor of interest exists as a discontinuous entity, with individuals either possessing the vulnerability or not.

    “The dichotomous diathesis-stress model holds that the vulnerability factor of interest exists as a discontinuous entity, with individuals either possessing the vulnerability or not (Ingram & Luxton, 2005).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Ingram & Luxton, 2005

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning

    A dimensional latent structure for a given vulnerability to depression does not invalidate its use in a high-risk design or negate the advantages such designs confer.

    “It should be noted that a dimensional latent structure for a given vulnerability to depression does not invalidate its use in a high-risk design or negate the aforementioned advantages it confers.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationcitation

    The current findings are consistent with those reported in an earlier taxometric investigation with an adult sample drawing on self-report measures (Gibb et al., 2004).

    “These findings are consistent with those reported in an earlier taxometric investigation with an adult sample drawing on self-report measures (Gibb et al., 2004).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Gibb et al., 2004 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    An additional advantage of high-risk designs is that the greater variability in vulnerability constructs they often afford yields greater statistical power to detect moderating effects by reducing standard errors without compromising parameter estimates.

    “An additional advantage of high-risk designs is that the greater variability in vulnerability constructs they often afford yields greater statistical power to detect the presence of moderating effects by reducing standard errors without compromising parameter estimates (Carter & Garber, 2011; McClelland & Judd, 1993).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Carter & Garber, 2011 source

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    • cites McClelland & Judd, 1993 source

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  • Classified as probably not a substantial claim.

    Study design and conductnone given

    A unique strength of the current study is its multi-method assessment of several distinct indices of cognitive vulnerability to depression to derive taxometric indicators for analysis.

    “A unique strength of the current study is its multi-method assessment of several distinct indices of cognitive vulnerability to depression to derive taxometric indicators for analysis.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisenone given

    One reason for adopting high-risk research designs is to increase the chance of prospectively capturing enough cases of a low base rate phenomenon for statistically powered analyses with a smaller sample, thereby increasing feasibility when resources are limited.

    “One reason for the adoption of high-risk research designs is to increase the chance of prospectively capturing a sufficient number of cases of a relatively low base rate phenomenon for statistically powered analyses, with a smaller sample than would otherwise be required, thereby increasing feasibility when resources may be limited.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    Cut-points on vulnerability measures are used in certain research contexts, most prominently in high-risk designs.

    “Cut-points on vulnerability measures are used in certain research contexts, perhaps one of the most prominent examples of which is high-risk designs.”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Carter & Garber, 2011 source

      Not checked in the free run.

    • cites Just, Abramson, & Alloy, 2001

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  • Classified as probably not a substantial claim.

    Premisecitation

    According to the vulnerability threshold model or the quasi-continuous diathesis model, risk for depression is only conferred above a certain level of the diathesis.

    “According to a second perspective, the vulnerability threshold model (Meiser & Esser, 2017), or a variation of it, the quasi-continuous diathesis model (Ingram & Luxton, 2005),3 risk for depression is only conferred above a certain level of the diathesis.”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites Meiser & Esser, 2017

      Not checked in the free run.

    • cites Ingram & Luxton, 2005

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  • Classified as probably not a substantial claim. May combine two claims.

    Premisecitation

    A contrasting position is that both vulnerability and stress operate in a graded manner, such that as diathetic loading increases, the level of stress required to precipitate depression decreases, and conversely as stress increases, a less severe diathesis is necessary for depression to occur.

    “A contrasting position that has garnered substantial interest is that both vulnerability and stress operate in a graded manner, such that as the diathetic loading increases, the level of stress required to precipitate depression decreases, and conversely as stress increases, a less severe diathesis is necessary for depression to occur (Monroe & Simons, 1991).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Monroe & Simons, 1991 source

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25 of 25
  • The paper relies on this without support.

    The current study is only the third taxometric study of psychiatric phenomena or their associated risk not to rely solely on self-report methodology, and the first such study relating to depression.

    “To our knowledge, this is only the third taxometric study of psychiatric phenomena or their associated risk not to rely solely on self-report methodology, and the first such study relating to depression.”
  • The paper relies on this without support.

    The findings from this community sample of early adolescents generalize to cognitive vulnerability to depression in adolescence more broadly.

    “The latent structure of the tested indices of cognitive vulnerability to depression in adolescence appears to exist along a continuum of severity rather than as a discrete clinical entity.”
2 of 2

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Cites

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Research works printed but not linked: 1

  1. Beck, 1987, Cognitive models of depression, Journal of Cognitive Psychotherapy, 1, 5

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Authors
Liu, R. T., McArthur, B. A., Burke, T. A., Hamilton, J. L., Mac Giollabhui, N., Stange, J. P., Hamlat, E. J., Abramson, L. Y., & Alloy, L. B.
Affiliations
  • Brown University (US)
  • Temple University (US)
  • University of Pittsburgh (US)
  • University of Illinois Chicago (US)
  • University of Illinois Urbana-Champaign (US)
  • University of Wisconsin–Madison (US)
Corresponding author
Liu, Richard T.
Venue
Behavior Therapy
Publisher
Elsevier BV
Published
2019-07
Volume
50
Issue
4
Pages
755-764
ISSN
0005-7894 (ISSN-L)
OpenAlex
W2903839664
Cited by
11
References
59
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2021: 1 · 2020: 3
FWCI
1.31
Type
journal article
Language
en
Open access
Locations
  • Behavior Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health
  • National Science Foundation
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
cognitive vulnerability to depression, adolescent depression, taxometric analysis, ruminative response style, risk assessment, early adolescence
MeSH terms
Adolescent, Adult, Cognition, Depression, Female, Humans, Male

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