Evidence for two genetically distinct pathways to co-occurring internalizing and externalizing problems in adolescence characterized by negative affectivity or behavioral inhibition.
Open accessAbstract
Unique pathways to adolescents' co-occurring internalizing/externalizing problems, a severe and common form of psychopathology, remain poorly delineated; this paucity of knowledge impedes the development of personalized interventions. We examined established measures of genetic risk and early childhood temperamental dimensions to clarify potentially distinct pathways to adolescents' co-occurring internalizing/externalizing problems. Participants were drawn from a longitudinal randomized controlled trial of a family-based intervention. The study employed multiple informants and methods, including observer ratings of toddlers' negative affectivity and behavioral inhibition, and primary caregiver ratings of toddlers' inhibitory control; internalizing and aggression polygenic risk scores (PRS) based on prior meta-genome-wide association studies (GWAS); and parents' and teachers' reports of adolescents' internalizing and externalizing problems. Higher levels of the aggression PRS indirectly predicted primary caregiver- and teacher-reported co-occurring problems relative to all other groups through greater early childhood negative affectivity. Lower levels of the aggression PRS and higher levels of the internalizing PRS indirectly predicted co-occurring problems relative to the externalizing "only" and low problem groups (primary caregivers only) through greater early childhood behavioral inhibition. Findings suggest two different genetic pathways to co-occurring problems that could lead to distinct prevention and intervention efforts. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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Lower aggression PRS and higher internalizing PRS indirectly predicted co-occurring problems relative to the externalizing only and low problem groups (primary caregivers only) through greater early childhood behavioral inhibition.
“Lower aggression PRS and higher internalizing PRS indirectly predicted co-occurring problems relative to the externalizing only and low problem groups (primary caregivers only) through greater early childhood behavioral inhibition.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Wang [116]
Higher aggression PRS indirectly predicted primary caregiver- and teacher-reported co-occurring problems relative to all other groups through greater early childhood negative affectivity.
“Higher aggression PRS indirectly predicted primary caregiver- and teacher-reported co-occurring problems relative to all other groups through greater early childhood negative affectivity.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Wang [116]
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- Authors
- Wang, F. L., Galán, C. A., Lemery-Chalfant, K., Wilson, M. N., & Shaw, D. S.
- Venue
- Journal of Abnormal Psychology
- Published
- 2020-08
- Volume
- 129
- Issue
- 6
- Pages
- 633-645
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- PMC
- PMC7415528
- OpenAlex
- W3032545476
- Cited by
- 25
- References
- 57
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Abnormal Psychology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (023245; 036832)
- National Institute on Alcohol Abuse and Alcoholism (007453)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- adolescence, negative affectivity, behavioral inhibition, early childhood temperament, inhibitory control, gene pathways, family intervention, prevention
- MeSH terms
- Problem Behavior, Adolescent, Affect, Aggression, Female, Humans, Inhibition, Psychological, Male, Parents, Risk Factors, Temperament, Genome-Wide Association Study
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