Vulnerability to stress-related sleep disturbance and insomnia: investigating the link with comorbid depressive symptoms
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= 2.97) from the Colorado Longitudinal Twin Study and Community Twin Study. Results indicated that greater sleep reactivity was significantly associated with elevated depressive symptoms, and that this link was partially mediated by insomnia. This is one of the first studies to demonstrate an independent association between sleep reactivity and depressive symptomatology. These findings suggest that a greater sensitivity to stress-related sleep disturbance may also be a predisposing factor to depression, and highlight the need for a better understanding of sleep reactivity, as it may represent a more global vulnerability construct.
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The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity.
“The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity [35, 62–65].”
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- Authors
- Vargas, I., Friedman, N. P., & Drake, C. L.
- Affiliations
- University of Colorado Boulder (US)
- Henry Ford Health (US)
- Venue
- Translational Issues in Psychological Science
- Published
- 2015-03
- Volume
- 1
- Issue
- 1
- Pages
- 57-66
- ISSN
- 2332-2136 (ISSN-L)
- 2332-2179
- PMC
- PMC4406050
- OpenAlex
- W2332192145
- Cited by
- 37
- References
- 46
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 4
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Translational Issues in Psychological Science (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Henry Ford Hospital
- National Institutes of Health (MH063207; DA011015)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep reactivity, insomnia, depressive symptoms, depression vulnerability, mediation, twin studies, genetic susceptibility
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