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Primary insomnia: a risk factor to develop depression?
Abstract
Background Chronic insomnia afflicts approximately 5-10% of the adult population in Western industrialized countries. Insomnia may be secondary, i.e. triggered and/or maintained by psychiatric/organic illnesses, the intake of prescribed/illicit drugs or alcohol, or by a combination of these factors. Insomnia can also occur as primary insomnia, caused by a psychophysiological hyperarousal process. In the present review a literature search was undertaken to identify longitudinal epidemiological studies which investigate the question whether primary insomnia at baseline predicts the development of depression at follow-up measurements.Methods MEDLINE search for the medical subject headings insomnia and depression; identification of longitudinal epidemiological studies with at least two measurement points 1 year apart measuring insomnia and depression and indicating explicit criteria for both disorders.Results Eight relevant epidemiological studies were identified. Almost unambiguously insomnia at baseline significantly predicted an increased depression risk at follow-up 1-3 years later.Conclusion As insomniac symptoms alone seem to be of predictive value for the development of depression in the succeeding years, it would be worthwhile to investigate if early adequate treatment is able to prevent psychiatric sequelae of primary insomnia.
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Insomnia is an independent risk factor for depression onset.
“Insomnia is not only a symptom of depression, but is a common precursor, with high-quality longitudinal data having established insomnia as an independent risk factor for depression onset.5–7”
From Pilot evaluation of the Sleep Ninja: A smartphone application for adolescent insomnia symptoms (2019) · cites this paper as [7]
Disturbed sleep and circadian rhythms are correlated with increased incidence of depression.
“and especially depression [6]”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [6]
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Self-citationThe Effects of Insomnia and Sleep Loss on Cardiovascular Disease
Khan, M. S., & Aouad, R. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.02.008 · Cited by 132
The Effects of Sleep Continuity Disruption on Positive Mood and Sleep Architecture in Healthy Adults
Finan, P. H., Quartana, P. J., & Smith, M. T. (2015) · Sleep · doi:10.5665/sleep.5154 · Cited by 140
Sonnenschein, M., Sorbi, M. J., van Doornen, L. J. P., Schaufeli, W. B., & Maas, C. J. M. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.11.011 · Cited by 123
Chronically Restricted or Disrupted Sleep as a Causal Factor in the Development of Depression
Meerlo, P., Havekes, R., & Steiger, A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_367 · Cited by 123
Dombrovski, A. Y., Cyranowski, J. M., Mulsant, B. H., Houck, P. R., Buysse, D. J., Andreescu, C., Thase, M. E., Mallinger, A. G., & Frank, E. (2008) · Depression and Anxiety · doi:10.1002/da.20467 · Cited by 116
Evaluation of Depressive Symptoms and Sleep Alterations in College Students
Estrella, J. M., Pérez-Benítez, H., Solı́s-Rodrı́guez, F., & Arankowsky‐Sandoval, G. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.03.018 · Cited by 115
Cognitive Behavioral Therapy for Insomnia in Depression
Asarnow, L. D., & Manber, R. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.01.009 · Cited by 115
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Heritability of Insomnia Symptoms in Youth and Their Relationship to Depression and Anxiety
Gehrman, P., Meltzer, L. J., Moore, M. E., Pack, A. I., Perlis, M. L., Eaves, L. J., & Silberg, J. L. (2011) · SLEEP · doi:10.5665/sleep.1424 · Cited by 116
Möller, H. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970801981606 · Cited by 117
Chronic Insomnia: Clinical and Research Challenges - An Agenda
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Self-citationThe genetics of insomnia – Evidence for epigenetic mechanisms?
Palagini, L., Biber, K. P. H., & Riemann, D. W. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.05.002 · Cited by 122
Self-citationDepressive Disorders in Restless Legs Syndrome
Hornyak, M. (2010) · CNS Drugs · doi:10.2165/11317500-000000000-00000 · Cited by 110
Association between a Serotonin Transporter Length Polymorphism and Primary Insomnia
Deuschle, M., Schredl, M., Schilling, C., Wüst, S., Frank, J., Witt, S. H., Rietschel, M., Buckert, M., Meyer‐Lindenberg, A., & Schulze, T. G. (2010) · SLEEP · doi:10.1093/sleep/33.3.343 · Cited by 109
Link between insomnia and perinatal depressive symptoms: A meta‐analysis
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Evaluating the links between schizophrenia and sleep and circadian rhythm disruption
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The association between insomnia and cardiovascular diseases
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Circadian Activity Rhythms and Mortality: The Study of Osteoporotic Fractures
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Cook, J. D., Prairie, M. L., & Plante, D. T. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.030 · Cited by 105
The course of insomnia over one year: a longitudinal study in the general population in Sweden
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Tazawa, Y., Liang, K.-C., Yoshimura, M., Kitazawa, M., Kaise, Y., Takamiya, A., Kishi, A., Horigome, T., Mitsukura, Y., Mimura, M., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03274 · Cited by 101
Diagnosing and Treating Depression in Patients with Alzheimer’s Disease
Burke, A. D., Goldfarb, D., Bollam, P., & Khokher, S. (2019) · Neurology and Therapy · doi:10.1007/s40120-019-00148-5 · Cited by 115
Li, Y., Zhang, S., Zhu, J., Du, X.-N., & Huang, F. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4054 · Cited by 100
Residual symptoms after remission of major depressive disorder with fluoxetine and risk of relapse
Iovieno, N., van Nieuwenhuizen, A., Clain, A., Baer, L., & Nierenberg, A. A. (2011) · Depression and Anxiety · doi:10.1002/da.20768 · Cited by 98
Metadata
- Authors
- Riemann, D.
- Affiliations
- University Medical Center Freiburg (DE)
- Corresponding author
- Riemann, D
- ORCID
- Riemann, D
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 76
- Issue
- 1-3
- Pages
- 255-259
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2154516720
- Semantic Scholar
- b8c0f4f8624614a33be6ebf15f3d53fc3d809e0d
- Cited by
- 641
- References
- 28
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 40 · 2023: 27 · 2022: 35 · 2021: 18 · 2020: 25 · 2019: 32 · 2018: 26 · 2017: 32 · 2016: 32 · 2015: 26 · 2014: 32 · 2013: 44 · 2012: 38
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- primary insomnia, depression, depression risk prediction, longitudinal epidemiology, insomnia treatment, psychiatric comorbidity
- MeSH terms
- Adult, Aged, Chronic Disease, Depressive Disorder, Female, Humans, Sleep Initiation and Maintenance Disorders, Longitudinal Studies, Male, Middle Aged, Risk Factors, Epidemiologic Studies
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