CoChat
Sign Up
Cited by 422Medical Imaging Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Mapping human visual cortex with positron emission tomography

Fox, Peter T., Mintun, Mark A., Raichle, Marcus E., Miezin, Francis M., Allman, John M., Van Essen, David C.·1986·Nature
DOI 10.1038/323806a0
Open this paper in CoChat — free account

Abstract

Positron-emission tomography (PET) can localize functions of the human brain by imaging regional cerebral blood flow (CBF) during voluntary behaviour. Functional brain mapping with PET, however, has been hindered by PET's poor spatial resolution (typically greater than 1 cm). We have developed an image-analysis strategy that can map functional zones not resolved by conventional PET images. Brain areas selectively activated by a behavioural task can be isolated by subtracting a paired control-state image from the task-state image, thereby removing areas not recruited by the task. When imaged in isolation the centre of an activated area can be located very precisely. This allows subtle shifts in response locale due to changes in task to be detected readily despite poor spatial resolution. As an initial application of this strategy we mapped the retinal projection topography of human primary visual cortex. Functional zones separated by less than 3 mm (centre-to-centre) were differentiated using PET CBF images with a spatial resolution of 18 mm. This technique is not limited to a particular brain area or type of behaviour but does require that the increase in CBF produced by the task be both intense and focal.

Overview

Integrity signals

Registry

Crossref · 10.1038/323806a0

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. Westheimer, G. Invest, ophthal. vis. Sci. 18, 893–912 (1979).
  2. Herscovitch, P., Markham, J & Raichle, M. E. J. nucl. Med. 24, 782–789 (1983).
  3. Raichle, M. E., Martin, W. R. W., Herscovitch, P., Mintun, M. A. & Markham, J. J. nucl. Med. 24, 790–798 (1983).

Cited by

Sorted by citations

See all 422

Related

See all

Metadata

Authors
Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M., & Van Essen, D. C.
Affiliations
  • Washington University in St. Louis (US)
  • California Institute of Technology (US)
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1986-10
Volume
323
Issue
6091
Pages
806-809
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/323806a0
OpenAlex
W1994364310
Cited by
422
References
22
Citations by year
2026: 2 · 2025: 7 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 19 · 2019: 6 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 8
FWCI
12.67
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
functional brain mapping, primary visual cortex, regional cerebral blood flow, positron emission tomography, spatial resolution, image subtraction, visual cortex
MeSH terms
Cerebrovascular Circulation, Humans, Image Enhancement, Regional Blood Flow, Subtraction Technique, Tomography, Emission-Computed, Visual Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review