Cited by 10,704Nitric Oxide and Endothelin EffectsEicosanoids and Hypertension PharmacologyCardiovascular Health and Disease Prevention

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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., Moncada, S.·1987·Nature

DOI 10.1038/327524a0

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Abstract

Endothelium-derived relaxing factor (EDRF) is a labile humoral agent which mediates the action of some vasodilators. Nitrovasodilators, which may act by releasing nitric oxide (NO), mimic the effect of EDRF and it has recently been suggested by Furchgott that EDRF may be NO. We have examined this suggestion by studying the release of EDRF and NO from endothelial cells in culture. No was determined as the chemiluminescent product of its reaction with ozone. The biological activity of EDRF and of NO was measured by bioassay. The relaxation of the bioassay tissues induced by EDRF was indistinguishable from that induced by NO. Both substances were equally unstable. Bradykinin caused concentration-dependent release of NO from the cells in amounts sufficient to account for the biological activity of EDRF. The relaxations induced by EDRF and NO were inhibited by haemoglobin and enhanced by superoxide dismutase to a similar degree. Thus NO released from endothelial cells is indistinguishable from EDRF in terms of biological activity, stability, and susceptibility to an inhibitor and to a potentiator. We suggest that EDRF and NO are identical.

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1. Furchgott, R. F. in Mechanisms of Vasodilatation Vol. IV (ed. Vanhoutte, P. M.) (Raven, New York, in the press). 2. Downes, M. J., Edwards, M. W., Elsey, T. S. & Walters, C. L. Analyst 101, 742–748 (1976). 3. Gryglewski, R. J., Moncada, S. & Palmer, R. M. J. Br. J. Pharmac 87, 685–694 (1986). 4. Griffith, T. M., Edwards, D. H., Lewis, M. J., Newby, A. C. & Henderson, A. H. Nature 308, 645–647 (1984). 5. Forstermann, U., Trogisch, G. & Busse, R. Eur. J. Pharmac. 106, 639–643 (1985). 6. Cocks, T. M. & Angus, J. A. in Vascular Neuroeffector Mechanisms (eds Bevan, J. A., Godfraind, T., Maxwell, R. A., Stoclet, J. C. & Worcel, M.) 131–136 (Elsevier, Amsterdam, 1985). 7. Martin, W., Villani, G. M., Jothianandan, D. & Furchgott, R. F. / Pharmac. exp. Ther. 232, 708–716 (1985). 8. Gibson, Q. H & Roughton, F. J. W. J. Physiol., Lond. 136, 507–526 (1957). 9. Gryglewski, R. J., Palmer, R. M. J. & Moncada, S. Nature 320, 454–456 (1986). 10. Rubanyi, G. M & Vanhoutte, P. M. Am. J. Physiol. 250, H222–H227 (1986). 11. Dale, H. H. Hull. Johns Hopkins Hosp. 53, 297–347 (1933). 12. Moncada, S., Palmer, R. M. J. & Gryglewski, R. J. Proc. natn. Acad. Sci. U.S.A. 83,9164–9168 (1986). 13. Blough, N. V. & Zafiriou, O. C. Inorg. Chem. 24, 3502–3504 (1985).

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Wink, D. A., Darbyshire, J. F., Nims, R. W., Saavedra, J. E., & Ford, P. C. (1993) · Chemical Research in Toxicology · doi:10.1021/tx00031a003 · Cited by 480
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Heales, S., Bolaños, J. P., Stewart, V. C., Brookes, P. S., Land, J. M., & Clark, J. B. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00168-6 · Cited by 473
Polycystic Ovary Syndrome Is Associated With Endothelial Dysfunction
Paradisi, G., Steinberg, H. O., Hempfling, A., Cronin, J., Brechtel, G., Shepard, M. K., & Baron, A. (2001) · Circulation · doi:10.1161/01.cir.103.10.1410 · Cited by 476
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.
Moro, M. Á., Russel, R., Cellek, S., Lizasoaín, I., Su, Y., Darley-Usmar, V. M., Radomski, M. W., & Moncada, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1480 · Cited by 473
Self-citation
17β-Estradiol Regulation of Human Endothelial Cell Basal Nitric Oxide Release, Independent of Cytosolic Ca 2+ Mobilization
Caulin‐Glaser, T., García‐Cardeña, G., Sarrel, P. M., Sessa, W. C., & Bender, J. R. (1997) · Circulation Research · doi:10.1161/01.res.81.5.885 · Cited by 479
Menopause Is Associated With Endothelial Dysfunction in Women
Taddei, S., Virdis, A., Ghiadoni, L., Mattei, P., Sudano, I., Bernini, G., Pinto, S., & Salvetti, A. (1996) · Hypertension · doi:10.1161/01.hyp.28.4.576 · Cited by 472
Roles of P2-purinoceptors in the cardiovascular system.
Ralevic, V., & Burnstock, G. (1991) · Circulation · doi:10.1161/01.cir.84.1.1 · Cited by 472
Anaphylaxis: a review of causes and mechanisms.
Kemp, S. F., & Lockey, R. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.126811 · Cited by 479
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
Hayashi, T., Fukuto, J. M., Ignarro, L. J., & Chaudhuri, G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11259 · Cited by 469
The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough
Wiest, R., & Groszmann, R. J. (2002) · Hepatology · doi:10.1053/jhep.2002.31432 · Cited by 466
Superoxide dismutases and their impact upon human health
Johnson, F., & Giulivi, C. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.07.006 · Cited by 467
Structure and Regulation of Soluble Guanylate Cyclase
Derbyshire, E. R., & Marletta, M. A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-050410-100030 · Cited by 466
Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia
Chowienczyk, P. (1992) · The Lancet · doi:10.1016/0140-6736(92)92621-l · Cited by 466
Free radical biology and medicine: it's a gas, man!
Pryor, W. A., Houk, K. N., Foote, C. S., Fukuto, J. M., Ignarro, L. J., Squadrito, G. L., & Davies, K. J. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00614.2005 · Cited by 480
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.
Hecker, M., Sessa, W. C., Harris, H. J., Änggård, E., & Vane, J. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8612 · Cited by 462
Nitric oxide generation from nitroprusside by vascular tissue
Bates, J. N., Baker, M. T., Guerra, R., & Harrison, D. G. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90406-u · Cited by 461
Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway
Julou‐Schaeffer, G., Gray, G. A., Fleming, I., Schott, C., Parratt, J. R., & Stoclet, J. C. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.4.h1038 · Cited by 461
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases
Leiper, J. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00162-5 · Cited by 458
Signal transduction of eNOS activation
Fleming, I. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00094-2 · Cited by 458

Authors: Palmer, R. M. J., Ferrige, A. G., & Moncada, S.
Affiliations: Wellcome Trust (GB)
ORCID: Palmer, R. M. J.
Moncada, S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1987-06
Volume: 327
Issue: 6122
Pages: 524-526
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/327524a0
OpenAlex: W2007737411
Cited by: 10,704
References: 0
Citations by year: 2026: 60 · 2025: 81 · 2024: 91 · 2023: 124 · 2022: 138 · 2021: 131 · 2020: 134 · 2019: 143 · 2018: 146 · 2017: 165 · 2016: 160 · 2015: 193 · 2014: 211 · 2013: 227 · 2012: 260
FWCI: 210.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: endothelium-derived relaxing factor, nitric oxide, endothelial cells, vasodilation, nitrovasodilators, bradykinin, superoxide dismutase, hemoglobin, chemiluminescence, ozone reactions
MeSH terms: Animals, Aorta, Bradykinin, Endothelium, Hemoglobins, Humans, Kinetics, Muscle Relaxation, Muscle, Smooth, Vascular, Nitric Oxide, Rabbits, Swine, Vasodilator Agents, In Vitro Techniques

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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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