The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cortical microstimulation influences perceptual judgements of motion direction
Abstract
Neurons in the visual cortex respond selectively to perceptually salient features of the visual scene, such as the direction and speed of moving objects, the orientation of local contours, or the colour or relative depth of a visual pattern. It is commonly assumed that the brain constructs its percept of the visual scene from information encoded in the selective responses of such neurons. We have now tested this hypothesis directly by measuring the effect on psychophysical performance of modifying the firing rates of physiologically characterized neurons. We required rhesus monkeys to report the direction of motion in a visual display while we electrically stimulated clusters of directionally selective neurons in the middle temporal visual area (MT, or V5), an extrastriate area that plays a prominent role in the analysis of visual motion information. Microstimulation biased the animals' judgements towards the direction of motion encoded by the stimulated neurons. This result indicates that physiological properties measured at the neuronal level can be causally related to a specific aspect of perceptual performance.
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In the citing paper
“A combination of recording, lesion, and stimulation studies has established that neurons in extrastriate cortex (areas MT and MST) carry critical sensory information about motion direction (Newsome and Pare, 1988;Salzman et al., 1990;1992;Britten et al., 1992;Celebrini and Newsome, 1994;1995).”
From Response of Neurons in the Lateral Intraparietal Area during a Combined Visual Discrimination Reaction Time Task (2002) · cites this paper as Salzman et al., 1990
In the citing paper
“Neurons in extrastriate visual cortex (areas MT and MST) furnish the”
From Response of Neurons in the Lateral Intraparietal Area during a Combined Visual Discrimination Reaction Time Task (2002) · cites this paper as Salzman et al., 1990
In the citing paper
“Thus, MT provides at least some of the motion information used to form the direction decision.”
From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [19]
In the citing paper
“the established role of MT in task performance16–19”
From Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area (2008) · cites this paper as [19]
Citations
Cites
Cox, D. R. (2008) · Springer eBooks · doi:10.1007/978-0-387-32833-1_5 · Cited by 2,687
Newsome, W., & Pare, E. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-06-02201.1988 · Cited by 1,615
Self-citationMaunsell, J. H. R., & Essen, D. C. V. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.49.5.1127 · Cited by 1,462
Neuronal correlates of a perceptual decision
Newsome, W. T., Britten, K. H., & Movshon, J. A. (1989) · Nature · doi:10.1038/341052a0 · Cited by 1,177
Self-citationColumnar specificity of intrinsic horizontal and corticocortical connections in cat visual cortex
Gilbert, C., & Wiesel, T. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-07-02432.1989 · Cited by 1,166
Direction and orientation selectivity of neurons in visual area MT of the macaque
Albright, T. D. (1984) · Journal of Neurophysiology · doi:10.1152/jn.1984.52.6.1106 · Cited by 1,089
Zeki, S. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010452 · Cited by 982
Stoney, S. D., Thompson, W., & Asanuma, H. (1968) · Journal of Neurophysiology · doi:10.1152/jn.1968.31.5.659 · Cited by 676
Newsome, W. T., Wurtz, R. H., Dürsteler, M., & Mikami, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-03-00825.1985 · Cited by 669
Self-citationNewsome, W. T., Wurtz, R. H., & Komatsu, H. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.60.2.604 · Cited by 649
Self-citationDubner, R. A., & Zeki, S. (1971) · Brain Research · doi:10.1016/0006-8993(71)90494-x · Cited by 636
Columnar organization of directionally selective cells in visual area MT of the macaque
Albright, T. D., Desimone, R., & Gross, C. G. (1984) · Journal of Neurophysiology · doi:10.1152/jn.1984.51.1.16 · Cited by 564
The organization of chromatic and spatial interactions in the primate striate cortex
Ts'o, D., & Gilbert, C. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01712.1988 · Cited by 548
Mikami, A., Newsome, W. T., & Wurtz, R. H. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.55.6.1308 · Cited by 357
Self-citationThe mode of activation of pyramidal tract cells by intracortical stimuli.
Jankowska, E., Padel, Y., & Tanaka, R. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp011034 · Cited by 269
Baker, J. F., Petersen, S. E., Newsome, W. T., & Allman, J. M. (1981) · Journal of Neurophysiology · doi:10.1152/jn.1981.45.3.397 · Cited by 235
Self-citationModulation of pursuit eye movements by stimulation of cortical areas MT and MST
Komatsu, H., & Wurtz, R. H. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.1.31 · Cited by 217
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Research works printed but not linked: 1
- Siegel, R. M. & Andersen, R. A. Soc. Neurosci. Abstr. 12, 1183 (1986).
Cited by
Sorted by citations
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 5,015
“Although direct electrical stimulation and recording of neurons in intact brain tissue have provided many insights into the function of circuit subfields (for example, see refs”
BackgroundThe Neural Basis of Decision Making
Gold, J. I., & Shadlen, M. N. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113038 · Cited by 3,764
“…decision is typically indicated with The evidence used to form the direction decision has further established a causal link for MT activity and task performance (Ditterich et al. 2003 ; Newsome & Par´e 1988; Salzman et al. 1990, 1992). of the neural mechanisms of decision formation formation.”
BackgroundA sensorimotor account of vision and visual consciousness
O'Regan, J. K., & Noë, A. (2001) · Behavioral and Brain Sciences · doi:10.1017/s0140525x01000115 · Cited by 3,126
Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
Dehaene, S. (2001) · Cognition · doi:10.1016/s0010-0277(00)00123-2 · Cited by 2,498
The analysis of visual motion: a comparison of neuronal and psychophysical performance
Britten, K., Shadlen, M., Newsome, W., & Movshon, J. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04745.1992 · Cited by 1,958
Self-citation
Metadata
- Authors
- Salzman, C. D., Britten, K. H., & Newsome, W. T.
- Affiliations
- Stanford Medicine (US)
- Venue
- Nature
- Published
- 1990-07-12
- Volume
- 346
- Issue
- 6280
- Pages
- 174-177
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2037781104
- Cited by
- 881
- References
- 17
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 25 · 2023: 24 · 2022: 27 · 2021: 24 · 2020: 46 · 2019: 33 · 2018: 29 · 2017: 26 · 2016: 25 · 2015: 37 · 2014: 31 · 2013: 31 · 2012: 23
- FWCI
- 19.44
- Type
- journal article
- Language
- en
- Update notices
- erratum (1990-08-09)
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- motion direction perception, directionally selective neurons, middle temporal area, V5, visual motion processing, neuronal firing rate, perceptual judgment, rhesus monkeys, visual cortex
- MeSH terms
- Animals, Electric Stimulation, Eye Movements, Macaca mulatta, Motion Perception, Visual Cortex, Visual Pathways, Visual Perception
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