Cited by 377Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses

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Otmakhova, Nonna A., Lisman, John E.·1996·The Journal of Neuroscience

Abstract

The role of the mesolimbic dopaminergic system in the reinforcement of learning suggests that dopamine should be able to modulate activity-dependent synaptic plasticity. We have examined the effect of D1/D5 agonists on early long-term potentiation (LTP) (40 min) in the CA1 region of hippocampal slices. D1/D5 agonists (+)bromo-APB, 6-chloro-PB, and dihydrexidine increased the magnitude of LTP in a synapse-specific manner (by approximately 10, 15, and 20%, respectively). This D1/D5 effect was mimicked by a low dose (10 microM) of the adenylyl cyclase activator forskolin. The D1/D5 antagonist (+)SCH 23390 reduced early LTP. In catecholamine-depleted slices, LTP was smaller by approximately 20-25% and could not be decreased further by D1/D5 antagonist. Under these conditions, D1/D5 agonist 6-chloro-PB and forskolin produced a larger enhancement of LTP (20-25%), restoring it to the control level. At the same dose, dideoxyforskolin did not affect early LTP. The D1/D5 agonist effect was completely blocked by the D1/D5 antagonist (+)SCH 23390. These results indicate that dopamine produces a synapse-specific enhancement of early LTP through D1/D5 receptors and cAMP.

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Crossref · 10.1523/jneurosci.16-23-07478.1996

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  1. Cooper SJ (1991) Interactions between endogenous opioids and dopa- mine: implications for reward and aversion. In: The mesolimbic dopa- mine system: from motivation to action (Wilner P, Scheel-Kruger J, eds), pp 331-366. New York: Wiley.

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Authors
Otmakhova, N. A., & Lisman, J. E.
Affiliations
Brandeis University (US)
Venue
The Journal of Neuroscience
Published
1996-12-01
Volume
16
Issue
23
Pages
7478-7486
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1868297237
Cited by
377
References
72
Citations by year
2026: 4 · 2025: 8 · 2024: 13 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 15 · 2017: 15 · 2016: 12 · 2015: 18 · 2014: 23 · 2013: 14 · 2012: 27
FWCI
3.37
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • W. M. Keck Foundation
  • Abbott Laboratories
  • National Institutes of Health
  • National Institute of Mental Health
  • National Institute of Neurological Disorders and Stroke (R01NS027337, 5 R01 NS27337-7)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dopamine D1/D5 receptors, long-term potentiation, hippocampal CA1, synaptic plasticity, adenylate cyclase, cAMP signaling, forskolin, SCH 23390, catecholamine depletion, learning reinforcement, mesolimbic dopamine system
MeSH terms
Animals, Catecholamines, Colforsin, Hippocampus, Rats, Inbred Strains, Synapses, Receptors, Dopamine D1, Long-Term Potentiation, Dopamine Agonists, Dopamine Antagonists, Receptors, Dopamine D5, Rats

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