Cited by 1,044DNA Repair MechanismsBacterial Genetics and BiotechnologyCRISPR and Genetic Engineering

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The importance of repairing stalled replication forks

Cox, Michael M., Goodman, Myron F., Kreuzer, Kenneth N., Sherratt, David J., Sandler, Steven J., Marians, Kenneth J.·2000·Nature

DOI 10.1038/35003501

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Abstract

The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.

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Authors: Cox, M. M., Goodman, M. F., Kreuzer, K. N., Sherratt, D. J., Sandler, S. J., & Marians, K. J.
Affiliations: University of Wisconsin System (US)
University of Southern California (US)
Duke Medical Center (US)
University of Oxford (GB)
University of Massachusetts Amherst (US)
Memorial Sloan Kettering Cancer Center (US)
ORCID: Cox, Michael M.
Goodman, Myron F.
Sherratt, David J.
Sandler, Steven J.
Marians, Kenneth J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-03
Volume: 404
Issue: 6773
Pages: 37-41
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35003501
OpenAlex: W1570361288
Cited by: 1,044
References: 63
Citations by year: 2026: 11 · 2025: 10 · 2024: 13 · 2023: 14 · 2022: 26 · 2021: 27 · 2020: 21 · 2019: 22 · 2018: 26 · 2017: 22 · 2016: 36 · 2015: 34 · 2014: 49 · 2013: 43 · 2012: 39
FWCI: 28.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of General Medical Sciences (R37GM034557)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Keywords: stalled replication forks, bacterial DNA damage, SOS response, homologous recombination, DNA repair, site-specific recombination, DNA metabolism
MeSH terms: Bacteria, Bacterial Proteins, Chromosomes, Bacterial, DNA Replication, DNA, Bacterial, Escherichia coli, Recombination, Genetic, SOS Response, Genetics, Replication Origin

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The importance of repairing stalled replication forks

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