The DOI matches its Crossref record; 96 of the 97 references it cites were found in a registry or an index.
Towards a molecular understanding of adaptive thermogenesis
Abstract
Obesity results when energy intake exceeds energy expenditure. Naturally occurring genetic mutations, as well as ablative lesions, have shown that the brain regulates both aspects of energy balance and that abnormalities in energy expenditure contribute to the development of obesity. Energy can be expended by performing work or producing heat (thermogenesis). Adaptive thermogenesis, or the regulated production of heat, is influenced by environmental temperature and diet. Mitochondria, the organelles that convert food to carbon dioxide, water and ATP, are fundamental in mediating effects on energy dissipation. Recently, there have been significant advances in understanding the molecular regulation of energy expenditure in mitochondria and the mechanisms of transcriptional control of mitochondrial genes. Here we explore these developments in relation to classical physiological views of adaptive thermogenesis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These latter forms of regulated heat production are referred to as adaptive thermogenesis 3, and occur primarily in the mitochondria of skeletal muscle and brown fat, which are distinct from other body tissues in that their thermogenesis is finely regulated and therefore has the potential to be manipulated therapeutically to serve as a target for obesity treatment.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [3]
In the citing paper
“These latter forms of regulated heat production are referred to as adaptive thermogenesis 3, and occur primarily in the mitochondria of skeletal muscle and brown fat, which are distinct from other body tissues in that their thermogenesis is finely regulated and therefore has the potential to be manipulated therapeutically to serve as a target for obesity treatment.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [3]
Citations
Cites
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citationRole of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Self-citationCellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630
Thermogenic mechanisms in brown fat.
Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
McCormack, J. G., Halestrap, A. P., & Denton, R. M. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.391 · Cited by 1,398
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379
The Response to Long-Term Overfeeding in Identical Twins
Bouchard, C., Tremblay, A., Després, J.-P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S., & Fournier, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222101 · Cited by 1,278
Cited by
Sorted by citations
Items 601–700 of 1,000
Arruda, A. P., da‐Silva, W. S., de Carvalho, D. P., & MEIS, L. D. (2003) · Biochemical Journal · doi:10.1042/bj20031015 · Cited by 48
Oldfield, B. J., Allen, A. M., Davern, P. J., Giles, M., & Owens, N. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05429.x · Cited by 48
Altered biodistribution on FDG-PET with emphasis on brown fat and insulin effect
Cohade, C. (2010) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2010.02.001 · Cited by 47
Takeda, Y., Harada, Y., Yoshikawa, T., & Dai, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021352 · Cited by 49
Verdeguer, F., Soustek, M. S., Hatting, M., Blättler, S. M., McDonald, D., Barrow, J. J., & Puigserver, P. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00722-15 · Cited by 47
Diet-induced changes in Ucp1 expression in bovine adipose tissues
Asano, H., Yamada, T., Hashimoto, O., Umemoto, T., Sato, R., Ohwatari, S., Kanamori, Y., Terachi, T., Funaba, M., & Matsui, T. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.01.006 · Cited by 49
Food Components with Anti-Obesity Effect
Kim, K., & Park, Y. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133656 · Cited by 47
Wang, G.-X., Cho, K. W., Uhm, M., Hu, C.-R., Li, S., Cozacov, Z., Xu, A. E., Cheng, J., Saltiel, A. R., Lumeng, C. N.-K., et al. (2013) · Diabetes · doi:10.2337/db13-1139 · Cited by 49
Cold-Inducible Klf9 Regulates Thermogenesis of Brown and Beige Fat
Fan, H., Zhang, Y., Zhang, J., Yao, Q., Song, Y., Shen, Q., Lin, J., Gao, Y., Wang, X., Zhang, L., et al. (2020) · Diabetes · doi:10.2337/db19-1153 · Cited by 46
Sarcolipin is a novel regulator of muscle metabolism and obesity
Maurya, S. K., & Periasamy, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.10.020 · Cited by 46
Thermogenesis in CD-1 mice after combined chronic hypoxia and cold acclimation
Beaudry, J. L., & McClelland, G. B. (2010) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2010.07.004 · Cited by 47
Control of OXPHOS efficiency by complex I in brain mitochondria
Cocco, T., Pacelli, C., Sgobbo, P., & Villani, G. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.002 · Cited by 47
Kräuchi, K., Konieczka, K., Roescheisen-Weich, C., Gompper, B., Hauenstein, D., Schoetzau, A., Fraenkl, S., & Flammer, J. (2014) · Chronobiology International · doi:10.3109/07420528.2013.829482 · Cited by 46
Cheng, L., Shi, L., He, C., Wang, C., Lv, Y., Li, H., An, Y., Dai, H., Duan, Y., Zhang, H., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7462 · Cited by 46
Souza-Tavares, H., Miranda, C. S., Vasques‐Monteiro, I. M. L., Sandoval, C., Santana-Oliveira, D. A., Silva-Veiga, F. M., Fernandes‐da‐Silva, A., & Souza‐Mello, V. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i26.4136 · Cited by 51
Chung, C. Y., & Yam, V. W. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201301547 · Cited by 46
Dietary polyphenols turn fat “brown”: A narrative review of the possible mechanisms
Hu, J., Wang, Z., Tan, B. K., & Christian, M. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.01.013 · Cited by 47
Huo, Y., Lu, X., Wang, X., Wang, X., Chen, L., Guo, H., Zhang, M., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25071490 · Cited by 45
Heterotopic Ossification Has Some Nerve
Salisbury, E. A., Sonnet, C., Heggeness, M. H., Davis, A. R., & Olmsted‐Davis, E. A. (2010) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v20.i4.30 · Cited by 46
Identification of a Ca2+-ATPase in Brown Adipose Tissue Mitochondria
MEIS, L. D., Arruda, A. P., da Costa, R. M., & Benchimol, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600678200 · Cited by 46
Mitochondrial Uncoupling Protein 2 (UCP2) in the Nonhuman Primate Brain and Pituitary
Diano, S., Urbanski, H. F., Horváth, B., Bechmann, I., Kagiya, A., Németh, G., Naftolin, F. N., Warden, C. H., & Horváth, T. L. (2000) · Endocrinology · doi:10.1210/endo.141.11.7740 · Cited by 52
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex
Shen, H., He, T., Wang, S., Hou, L., Wei, Y., Liu, Y., Mo, C., Zhao, Z., You, W., Guo, H., et al. (2022) · Theranostics · doi:10.7150/thno.77102 · Cited by 45
Nadal-Casellas, A., Proenza, A. M., Lladó, I., & Gianotti, M. (2011) · Steroids · doi:10.1016/j.steroids.2011.04.009 · Cited by 47
Kundu, S., Mukherjee, D., Maiti, T. K., & Sarkar, N. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00107 · Cited by 45
Yuan, J., Zhang, R., Wu, R., Gu, Y., & Lu, Y. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110903 · Cited by 45
Heppner, K. M., Marks, S., Holland, J., Ottaway, N., Smiley, D., DiMarchi, R. D., & Pérez–Tilve, D. (2015) · Diabetologia · doi:10.1007/s00125-015-3651-3 · Cited by 46
Wingfield, J. C. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.11.005 · Cited by 44
Akieda‐Asai, S., Zaima, N., Ikegami, K., Kahyo, T., Yao, I., Hatanaka, T., Iemura, S.-I., Sugiyama, R., Yokozeki, T., Eishi, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011755 · Cited by 45
Thermogenic adipocytes: From cells to physiology and medicine
Díaz, M. B., Herzig, S., & Vegiopoulos, A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.002 · Cited by 45
Jacobsson, J. A., Schiöth, H. B., & Fredriksson, R. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01025.x · Cited by 45
Sarcolipin Provides a Novel Muscle-Based Mechanism for Adaptive Thermogenesis
Gamu, D., Bombardier, É., Smith, I. C. P., Fajardo, V. A., & Tupling, A. R. (2014) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000016 · Cited by 48
Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors
Sánchez-Alavez, M., Osborn, O., Tabarean, I. V., Holmberg, K. H., Eberwine, J. H., Kahn, C. R., & Bartfai, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188540 · Cited by 44
Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages
Zhang, Y., Du, C., Wang, W., Qiao, W., Li, Y., Zhang, Y., Sheng, S., Zhou, X., Zhang, L., Fan, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45477-8 · Cited by 43
Arruda, A. P., Nigro, M., Oliveira, G. M., & MEIS, L. D. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.03.016 · Cited by 43
Expression of Adipocyte Biomarkers in a Primary Cell Culture Models Reflects Preweaning Adipobiology
Chu, D., Malinowska, E., Gawrońska‐Kozak, B., & Kozak, L. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.555821 · Cited by 42
Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T., & Osakabe, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137809 · Cited by 43
Effects of dietary phosphate on glucose and lipid metabolism
Abuduli, M., Ohminami, H., Otani, T., Kubo, H., Ueda, H., Kawai, Y., Masuda, M., Yamanaka‐Okumura, H., Sakaue, H., Yamamoto, H., et al. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00234.2015 · Cited by 45
Metabolic changes over the course of aging in a mouse model of tau deposition
Joly‐Amado, A., Serraneau, K. S., Brownlow, M. L., de Evsikova, C. M., Speakman, J. R., Gordon, M. N., & Morgan, D. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.013 · Cited by 43
Cero, C., Razzoli, M., Han, R., Sahu, B. S., Patricelli, J., Guo, Z., Zaidman, N. A., Miles, J. M., O’Grady, S. M., & Bartolomucci, A. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.005 · Cited by 43
Masand, R., Paulo, E., Wu, D., Wang, Y., Swaney, D. L., Jimenez‐Morales, D., Krogan, N. J., & Wang, B. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.018 · Cited by 43
Guo, J., Fang, B., Bai, H., Wang, L., Peng, B., Qin, X.-J., Fu, L., Yao, C., Li, L., & Huang, W. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116697 · Cited by 44
Risperidone alters food intake, core body temperature, and locomotor activity in mice
Cope, M. B., Li, X., Jumbo‐Lucioni, P. P., DiCostanzo, C. A., Jamison, W. G., Kesterson, R. A., Allison, D. B., & Nagy, T. R. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.11.011 · Cited by 45
Garruti, G., Wang, H. H., Bonfrate, L., de Bari, O., Wang, D. Q. ‐., & Portincasa, P. (2012) · Journal of Lipids · doi:10.1155/2012/304292 · Cited by 43
Wu, M., Chou, H., & Huang, C. (2014) · Marine Drugs · doi:10.3390/md12020964 · Cited by 42
Gómez‐Ambrosi, J., Frühbeck, G., & Martínez, J. A. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00451-8 · Cited by 43
Caffeine dose-dependently induces thermogenesis but restores ATP in HepG2 cells in culture
Riedel, A., Pignitter, M., Hochkogler, C. M., Lieder, B., Walker, J., Bytof, G., Lantz, I., & Somoza, V. (2012) · Food & Function · doi:10.1039/c2fo30053b · Cited by 42
Nanotherapeutic approaches to target mitochondria in cancer
Mani, S., Swargiary, G., Tyagi, S., Singh, M., Jha, N. K., & Singh, K. K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119773 · Cited by 43
Iwasaki, Y., TAMURA, Y., Inayoshi, K., Narukawa, M., Kobata, K., CHIBA, H., Muraki, E., Tsunoda, N., & Watanabe, T. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100850 · Cited by 42
Chung, Y. W., Ahmad, F., Tang, Y., Hockman, S. C., Kee, H. J., Berger, K., Guirguis, E., Choi, Y. H., Schimel, D., Aponte, A. M., et al. (2017) · Scientific Reports · doi:10.1038/srep40445 · Cited by 45
Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue
Moraes, M. N., de Assis, L. V. M., Henriques, F. D. S., Júnior, M. L. B., Güler, A. D., & Castrucci, A. M. D. L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.09.011 · Cited by 41
Human brown adipose tissue: Underestimated target in metabolic disease?
Moonen, M. P. B., Nascimento, E. B. M., & Lichtenbelt, W. D. V. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.05.012 · Cited by 43
Farzi, A., Lau, J., Ip, C. K., Qi, Y., Shi, Y., Zhang, L., Tasan, R. O., Sperk, G., & Herzog, H. (2018) · eLife · doi:10.7554/elife.36494 · Cited by 42
Novel Aspects of Brown Adipose Tissue Biology
Heeren, J., & Münzberg, H. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.004 · Cited by 43
Mice lacking brain-type creatine kinase activity show defective thermoregulation
Streijger, F., Pluk, H., Oerlemans, F. T. J. J., Beckers, G., Bianco, A. C., Ribeiro, M. O., Wieringa, B., & der Zee, C. E. E. M. V. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.003 · Cited by 44
Unami, A., Shinohara, Y., Kajimoto, K., & Baba, Y. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.09.010 · Cited by 42
Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice
Seo, D. H., Shin, E., Lee, Y., Park, S., Nam, K. T., Kim, J. W., & Soo, B. (2022) · Biomedicines · doi:10.3390/biomedicines10081852 · Cited by 41
Li, H., Kang, J., Han, J., Cho, M.-H., Chung, Y., Park, K. H., Shin, D., Park, H.-Y., Choi, M., & Jeong, T. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3388 · Cited by 41
Ngoc, H. L., Shin, S., Tu, T. H., Kim, C.-S., Kang, J., Goto, T., Teruo, K., Han, S. N., & Yu, R. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303548k · Cited by 41
Ablation of NG2 Proteoglycan Leads to Deficits in Brown Fat Function and to Adult Onset Obesity
Chang, Y., She, Z., Sakimura, K., Roberts, A. J., Kuchárová, K., Rowitch, D. H., & Stallcup, W. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030637 · Cited by 42
Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression
Ikegami, K., Atsumi, Y., Yorinaga, E., Ono, H., Murayama, I., Nakane, Y., Ota, W., Arai, N., Tega, A., Iigo, M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1741 · Cited by 41
Metabolic benefits of inhibition of p38α in white adipose tissue in obesity
Zhang, S., Cao, H., Li, Y., Jing, Y., Liu, S., Cheng, Y., Wang, H., Yu, S., Peng, C., Hui, L., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004225 · Cited by 41
Nagai, N., Sakane, N., Tsuzaki, K., & Moritani, T. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.261 · Cited by 41
Processed Aconite Root Prevents Cold-Stress-Induced Hypothermia and Immuno-Suppression in Mice
Makino, T., Kato, K., & Mizukami, H. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1741 · Cited by 41
Temperature-Triggered Periodical Thermogenic Oscillations in Skunk Cabbage (Symplocarpus foetidus)
Ito, K., Ito, T., Onda, Y., & Uemura, M. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch038 · Cited by 41
Decrease of intracellular ATP content downregulated UCP2 expression in mouse hepatocytes
Cheng, G., Polito, C. C., Haines, J. K., Shafizadeh, S. F., Fiorini, R. N., Zhou, X., Schmidt, M. G., & Chavin, K. D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01409-8 · Cited by 41
Peralta, J. G., Finocchietto, P. V., Converso, D. P., Schopfer, F. J., Carreras, M. C., & Poderoso, J. J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00785.2002 · Cited by 41
Vargas‐Castillo, A., Sun, Y., Smythers, A. L., Grauvogel, L., Dumesic, P. A., Emont, M. P., Tsai, L. T.-Y., Rosen, E. D., Zammit, N. W., Shaffer, S. M., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.002 · Cited by 44
Self-citationSalisbury, E. A., Lazard, Z. W., Ubogu, E. E., Davis, A. R., & Olmsted‐Davis, E. A. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0090 · Cited by 40
Melanocortin-3 Receptors and Metabolic Homeostasis
Begriche, K., Clemence, G., McDonald, P. H., & Butler, A. A. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386933-3.00004-2 · Cited by 42
神尾直哉, Suzuki, T., Watanabe, Y., Suhara, Y., & Osakabe, N. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.030 · Cited by 42
Cubo, J., & Jalil, N. (2019) · Paleobiology · doi:10.1017/pab.2019.13 · Cited by 40
Temperature Sensing in Cells Using Polymeric Upconversion Nanocapsules
İyisan, B., Thiramanas, R., Nazarova, N. V., Avlasevich, Y., Mailänder, V., Baluschev, S. B., & Landfester, K. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00377 · Cited by 40
Gerschenson, M., Shiramizu, B. T., Libutti, D. E., & Shikuma, C. M. (2005) · Antiviral Therapy · doi:10.1177/135965350501002s09 · Cited by 40
Martagón, A. J., Lin, J. Z., Cimini, S. L., Webb, P., & Phillips, K. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122987 · Cited by 41
Intracellular temperature mapping with fluorescence-assisted photoacoustic-thermometry
Gao, L. S., Zhang, C., Li, C., & Wang, L. V. (2013) · Applied Physics Letters · doi:10.1063/1.4807140 · Cited by 39
The influence of diabetes on cardiac β-adrenoceptor subtypes
ALTAN, V. M., Arıoglu, E., Güner, Ş., & Ozcelikay, A. T. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9005-6 · Cited by 39
Nie, L., Yuan, X., Jiang, K., Jiang, Y., Yuan, J., Luo, L., Cui, S., & Sun, C. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.08.004 · Cited by 39
Updating the markers for oocyte quality evaluation: intracellular temperature as a new index
Hoshino, Y. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12245 · Cited by 39
The sarcoplasmic reticulum and SERCA: a nexus for muscular adaptive thermogenesis
Gamu, D., Juracic, E. S., Hall, K. J., & Tupling, A. R. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0067 · Cited by 40
Niacin fine‐tunes energy homeostasis through canonical GPR109A signaling
Ye, L., Cao, Z., Lai, X., Wang, W., Guo, Z., Yan, L., Wang, Y., Shi, Y., & Zhou, N. (2018) · The FASEB Journal · doi:10.1096/fj.201801951r · Cited by 38
Lim, S., Park, J., & Um, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01154 · Cited by 39
Yook, J., Thomas, S. S., Toney, A. M., You, M., Kim, Y.-C., Liu, Z., Lee, J., & Chung, S. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab222 · Cited by 41
Wu, R., Cao, S., Li, F., Feng, S., Shu, G., Wang, L., Gao, P., Zhu, X., Zhu, C., Wang, S., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101810rr · Cited by 39
Peña‐Orihuela, P. J., Camargo, A., Rangel-Zúñiga, O. A., Pérez‐Martínez, P., Cruz‐Teno, C., Delgado‐Lista, J., Yubero‐Serrano, E. M., Paniagua, J. A., Tinahones, F. J., Malagón, M. M., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.02.012 · Cited by 39
Gender Disparity of Hepatic Lipid Homoeostasis Regulated by the Circadian Clock
Yang, X., Zhang, Y.-K. J., Esterly, N., Klaassen, C. D., & Wan, Y.-J. Y. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp018 · Cited by 38
Sex Differences in the Metabolic Effects of Testosterone in Sheep
Clarke, S. D., Clarke, I. J., Rao, A., Cowley, M. A., & Henry, B. A. (2011) · Endocrinology · doi:10.1210/en.2011-1634 · Cited by 42
Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity
Mwangi, S. M., Nezami, B. G., Obukwelu, B., Anitha, M., Marri, S., Fu, P. P., Epperson, M., Le, N., Shanmugam, M., Sitaraman, S. V., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00364.2013 · Cited by 41
Xiao, Y., Deng, Y., Yuan, F., Xia, T., Liu, H., Li, Z., Liu, Z., Ying, H., Liu, Y., Zhai, Q., et al. (2017) · Diabetes · doi:10.2337/db16-1546 · Cited by 40
Truswell, A. S. (1999) · Cited by 39
Sohn, J. H., Mutlu, B., Latorre‐Muro, P., Liang, J., Bennett, C. F., Sharabi, K., Kantorovic, N., Jedrychowski, M. P., Gygi, S. P., Banks, A. S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.015 · Cited by 38
Aggregation-induced emission-based fluorescent probes for cellular microenvironment detection
Li, X.-F., & Wu, F. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117130 · Cited by 38
Ueta, C. B., Olivares, E. L., & Bianco, A. C. (2011) · Endocrinology · doi:10.1210/en.2011-1066 · Cited by 38
Acute and chronic cold exposure differentially affects the browning of porcine white adipose tissue
Gao, Y., Qimuge, N., Qin, J., Cai, R., Li, X., Chu, G., Pang, W., & Yang, G. (2017) · animal · doi:10.1017/s1751731117002981 · Cited by 38
Nymo, S., Coutinho, S. R., Torgersen, L.-C. H., Bomo, O. J., Haugvaldstad, I., Truby, H., Kulseng, B. E., & Martins, C. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000922 · Cited by 42
Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue
Uchida, K., Sun, W., Yamazaki, J., & Tominaga, M. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00063 · Cited by 38
Lévy, S., Klimova, T. M., Николаевна, З. Р., Federov, A. I., Fedorov, A. I., Baltakhinova, M. E., & Leonard, W. R. (2018) · American Journal of Human Biology · doi:10.1002/ajhb.23175 · Cited by 38
Qian, R., Lv, J. C., & Long, Y. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04159 · Cited by 38
Rodríguez‐Rodríguez, R., Miralpeix, C., Fosch, A., Pozo, M., Calderón‐Domínguez, M., Perpiñà, X., Vellvehi, M., López, M., Herrero, L., Serra, D., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.010 · Cited by 38
Khare, P., Mangal, P., Baboota, R. K., Jagtap, S., Kumar, V., Singh, D. P., Boparai, R. K., Sharma, S. S., Khardori, R. K., Bhadada, S. K., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01244 · Cited by 39
Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study
Chathoth, S., Ismail, M. H., Vatte, C., Cyrus, C., Al-Ali, Z. A., Ahmed, K. A., Acharya, S., Barqi, A. M. A., & Ali, A. A. (2018) · BMC Medical Genetics · doi:10.1186/s12881-018-0715-5 · Cited by 38
Metadata
- Authors
- Lowell, B. B., & Spiegelman, B. M.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Corresponding author
- Lowell, Bradford B.
- Spiegelman, Bruce M.
- Venue
- Nature
- Published
- 2000-04
- Volume
- 404
- Issue
- 6778
- Pages
- 652-660
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1575263278
- Cited by
- 1,630
- References
- 97
- Citations by year
- 2026: 41 · 2025: 45 · 2024: 47 · 2023: 48 · 2022: 69 · 2021: 70 · 2020: 74 · 2019: 71 · 2018: 84 · 2017: 76 · 2016: 71 · 2015: 77 · 2014: 81 · 2013: 68 · 2012: 67
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adaptive thermogenesis, energy expenditure, obesity, mitochondria, mitochondrial transcription, energy balance, ambient temperature, diet
- MeSH terms
- Uncoupling Protein 1, Adaptation, Physiological, Animals, Body Temperature, Brain, Adipose Tissue, Brown, Carrier Proteins, DNA-Binding Proteins, Energy Metabolism, Food, Forecasting, Gene Expression Regulation, Humans, Ion Channels, Membrane Proteins, Mitochondria, Transcription Factors, Transcription, Genetic, Trans-Activators, Muscle, Skeletal, Mitochondrial Proteins, Nuclear Respiratory Factors, GA-Binding Protein Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
