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Towards a molecular understanding of adaptive thermogenesis
Abstract
Obesity results when energy intake exceeds energy expenditure. Naturally occurring genetic mutations, as well as ablative lesions, have shown that the brain regulates both aspects of energy balance and that abnormalities in energy expenditure contribute to the development of obesity. Energy can be expended by performing work or producing heat (thermogenesis). Adaptive thermogenesis, or the regulated production of heat, is influenced by environmental temperature and diet. Mitochondria, the organelles that convert food to carbon dioxide, water and ATP, are fundamental in mediating effects on energy dissipation. Recently, there have been significant advances in understanding the molecular regulation of energy expenditure in mitochondria and the mechanisms of transcriptional control of mitochondrial genes. Here we explore these developments in relation to classical physiological views of adaptive thermogenesis.
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“These latter forms of regulated heat production are referred to as adaptive thermogenesis 3, and occur primarily in the mitochondria of skeletal muscle and brown fat, which are distinct from other body tissues in that their thermogenesis is finely regulated and therefore has the potential to be manipulated therapeutically to serve as a target for obesity treatment.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [3]
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“These latter forms of regulated heat production are referred to as adaptive thermogenesis 3, and occur primarily in the mitochondria of skeletal muscle and brown fat, which are distinct from other body tissues in that their thermogenesis is finely regulated and therefore has the potential to be manipulated therapeutically to serve as a target for obesity treatment.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [3]
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Cites
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citationRole of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Self-citationCellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630
Thermogenic mechanisms in brown fat.
Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
McCormack, J. G., Halestrap, A. P., & Denton, R. M. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.391 · Cited by 1,398
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379
The Response to Long-Term Overfeeding in Identical Twins
Bouchard, C., Tremblay, A., Després, J.-P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S., & Fournier, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222101 · Cited by 1,278
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Items 101–200 of 1,000
A Novel Brain-Expressed Protein Related to Carnitine Palmitoyltransferase I
Price, N. T., van der Leij, F. R., Jackson, V. N., Corstorphine, C. G., Thomson, R., Sørensen, A., & Zammit, V. A. (2002) · Genomics · doi:10.1006/geno.2002.6845 · Cited by 282
A century of mitochondrial research: achievements and perspectives
Scheffler, I. E. (2001) · Mitochondrion · doi:10.1016/s1567-7249(00)00002-7 · Cited by 268
A critique of methods for temperature imaging in single cells
Baffou, G., Rigneault, H., Marguet, D., & Jullien, L. (2014) · Nature Methods · doi:10.1038/nmeth.3073 · Cited by 267
Subcutaneous fat in normal and diseased states
Avram, M. M., Avram, A. S., & James, W. D. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.06.022 · Cited by 269
Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15737 · Cited by 314
Adaptive Thermoregulation in Endotherms May Alter Responses to Climate Change
Boyles, J. G., Seebacher, F., Smit, B., & McKechnie, A. E. (2011) · Integrative and Comparative Biology · doi:10.1093/icb/icr053 · Cited by 274
Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vučković, I., Laznik-Bogoslavski, D., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.009 · Cited by 269
Self-citationOrexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function
Sellayah, D., Bharaj, P., & Sikder, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.010 · Cited by 259
Invited Review: Uncoupling proteins and thermoregulation
Argyropoulos, G. A., & Harper, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00994.2001 · Cited by 258
Mitochondria: a hub of redox activities and cellular distress control
Kakkar, P., & Singh, B. K. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9520-8 · Cited by 255
UCP1 is essential for adaptive adrenergic nonshivering thermogenesis
Golozoubova, V., Cannon, B., & Nedergaard, J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2005 · Cited by 255
Excitation‐transcription coupling in skeletal muscle: the molecular pathways of exercise
Gundersen, K. (2010) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2010.00161.x · Cited by 281
Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation
Quan, L., Zhang, C., Dong, M., Jiang, J., Xu, H., Yan, C., Liu, X., Zhou, H., Zhang, H., Chen, L., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-319114 · Cited by 258
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Iannucci, C. V., & Leonetti, F. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02247.x · Cited by 253
Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00075 · Cited by 252
Micro/Nanoscale Thermometry for Cellular Thermal Sensing
Bai, T., & Gu, N. (2016) · Small · doi:10.1002/smll.201600665 · Cited by 252
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Steffensen, K. R., & Gustafsson, J.-Α. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s36 · Cited by 256
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong, M., Yang, X., Lim, S., Cao, Z., Honek, J., Lu, H., Zhang, C., Seki, T., Hosaka, K., Wahlberg, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.003 · Cited by 240
Mitochondria in White, Brown, and Beige Adipocytes
Čedíková, M., Kripnerová, M., Dvořáková, J., Pitule, P., Grundmanova, M., Babuška, V., Müllerová, D., & Kuncová, J. (2016) · Stem Cells International · doi:10.1155/2016/6067349 · Cited by 249
A Long Noncoding RNA Transcriptional Regulatory Circuit Drives Thermogenic Adipocyte Differentiation
Zhao, X.-Y., Li, S., Wang, G.-X., Yu, Q., & Lin, J. D. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.004 · Cited by 231
Brown adipose tissue and thermogenesis
Fenzl, A., & Kiefer, F. W. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0022 · Cited by 239
Reinke, H., Saini, C., Fleury-Olela, F., Dibner, C., Benjamin, I. J., & Schibler, U. (2008) · Genes & Development · doi:10.1101/gad.453808 · Cited by 237
Yau, W. W., Singh, B. K., Lesmana, R., Zhou, J., Sinha, R. A., Wong, K. A., Wu, Y., Bay, B.-H., Sugii, S., Sun, L., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1511263 · Cited by 229
SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
Ramadori, G., Fujikawa, T., Fukuda, M., Anderson, J. G., Morgan, D. A., Mostoslavsky, R., Stuart, R. C., Perelló, M., Vianna, C. R., Nillni, E. A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.010 · Cited by 226
Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells
Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., & Miyashita, K. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.1.147 · Cited by 226
Warming the mouse to model human diseases
Ganeshan, K., & Chawla, A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.48 · Cited by 222
Chatterjee, N., & Perrimon, N. (2021) · Science Advances · doi:10.1126/sciadv.abg4336 · Cited by 224
Kim, K. W., Zhao, L., Donato, J., Kohno, D., Xu, Y., Elias, C. F., Lee, C., Parker, K. L., & Elmquist, J. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102364108 · Cited by 219
Medical Sequencing at the Extremes of Human Body Mass
Ahituv, N., Kavaslar, N., Schackwitz, W., Ustaszewska, A., Martin, J., Hébert, S., Doelle, H., Ersoy, B. A., Kryukov, G. V., Schmidt, S., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/513471 · Cited by 225
Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance
Obici, S., & Rossetti, L. (2003) · Endocrinology · doi:10.1210/en.2003-0999 · Cited by 222
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Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., et al. (2005) · Nature Medicine · doi:10.1038/nm1214 · Cited by 200
The role of skeletal‐muscle‐based thermogenic mechanisms in vertebrate endothermy
Rowland, L. A., Bal, N. C., & Periasamy, M. (2014) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12157 · Cited by 233
Hu, J., Zhang, G., Ge, Z., & Liu, S. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.10.006 · Cited by 219
Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism
Pan, D., Fujimoto, M., Lopes, A., & Wang, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.051 · Cited by 224
Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota
Bauer, P. V., Hamr, S. C., & Duca, F. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2083-z · Cited by 231
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Odegaard, J. I., & Chawla, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.001 · Cited by 219
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Frontini, A., Vitali, A., Perugini, J., Murano, I., Romiti, C., Ricquier, D., Guerrieri, M., & Cinti, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.005 · Cited by 218
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Wan, Q., Qin, W., Ma, Y., Shen, M., Li, J., Zhang, Z., Chen, J., Tay, F. R., Niu, L., & Jiao, K. (2021) · Advanced Science · doi:10.1002/advs.202003390 · Cited by 217
Bingham, N. C., Anderson, K. K., Reuter, A. L., Stallings, N. R., & Parker, K. L. (2008) · Endocrinology · doi:10.1210/en.2007-1200 · Cited by 221
A fundamental system of cellular energy homeostasis regulated by PGC-1α
Rohas, L. M., St‐Pierre, J., Uldry, M., Jäger, S., Handschin, C., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702683104 · Cited by 216
Self-citationUCP1 deficiency increases susceptibility to diet‐induced obesity with age
Kontani, Y., Wang, Y., Kimura, K., Inokuma, K. ‐., Saito, M., Suzuki‐Miura, T., Wang, Z., Sato, Y., Mori, N., & Yamashita, H. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00157.x · Cited by 207
A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing
Xue, K., Wang, C., Wang, J., Lv, S., Hao, B., Zhu, C., & Tang, B. Z. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c04597 · Cited by 207
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Bueter, M., Löwenstein, C., Olbers, T., Wang, M., Cluny, N. L., Bloom, S. R., Sharkey, K. A., Lutz, T. A., & le Roux, C. W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.012 · Cited by 213
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Aguirre, L., Fernández-Quintela, A., Arias, N., & Portillo, M. (2014) · Molecules · doi:10.3390/molecules191118632 · Cited by 205
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Guo, H., Jin, D., Zhang, Y., Wright, W. S., Bazuine, M., Brockman, D. A., Bernlohr, D., & Chen, X. (2010) · Diabetes · doi:10.2337/db09-1735 · Cited by 214
Wong, K. E., Kong, J., Zhang, W., Szeto, F. L., Ye, H., Deb, D. K., Brady, M., & Li, Y. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257568 · Cited by 205
Chen, Z., Zhang, K. Y., Tong, X., Liu, Y., Hu, C., Liu, S., Yu, Q., Zhao, Q., & Huang, W. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600706 · Cited by 202
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Ke, G., Wang, C., Ge, Y., Zheng, N., Zhu, Z., & Yang, C. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3082439 · Cited by 196
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Yen, C. E., Cheong, M.-L. J., Grueter, C. A., Zhou, P., Moriwaki, J., Wong, J. S., Hubbard, B. K., Marmor, S., & Farese, R. V. (2009) · Nature Medicine · doi:10.1038/nm.1937 · Cited by 181
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Zhang, Y., Matheny, M. E., Zolotukhin, S., Tümer, N., & Scarpace, P. J. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00298-6 · Cited by 170
Clinical significance of adaptive thermogenesis
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Cheng, Y., Meng, Q., Wang, C., Li, H., Huang, Z., Chen, S., Xiao, F., & Guo, F. (2009) · Diabetes · doi:10.2337/db09-0929 · Cited by 167
Subcutaneous fat in normal and diseased states
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Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance
Morales, H. E., Pavlova, A., Joseph, L., & Sunnucks, P. (2015) · Molecular Ecology · doi:10.1111/mec.13203 · Cited by 169
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Ravussin, É., & Galgani, J. E. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145209 · Cited by 173
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Self-citationLustig, R. H. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0220 · Cited by 162
Oishi, Y., Manabe, I., Tobe, K., Ohsugi, M., Kubota, T., Fujiu, K., Maemura, K., Kubota, N., Kadowaki, T., & Nagai, R. (2008) · Nature Medicine · doi:10.1038/nm1756 · Cited by 165
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Metadata
- Authors
- Lowell, B. B., & Spiegelman, B. M.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Corresponding author
- Lowell, Bradford B.
- Spiegelman, Bruce M.
- Venue
- Nature
- Published
- 2000-04
- Volume
- 404
- Issue
- 6778
- Pages
- 652-660
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1575263278
- Cited by
- 1,630
- References
- 97
- Citations by year
- 2026: 41 · 2025: 45 · 2024: 47 · 2023: 48 · 2022: 69 · 2021: 70 · 2020: 74 · 2019: 71 · 2018: 84 · 2017: 76 · 2016: 71 · 2015: 77 · 2014: 81 · 2013: 68 · 2012: 67
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adaptive thermogenesis, energy expenditure, obesity, mitochondria, mitochondrial transcription, energy balance, ambient temperature, diet
- MeSH terms
- Uncoupling Protein 1, Adaptation, Physiological, Animals, Body Temperature, Brain, Adipose Tissue, Brown, Carrier Proteins, DNA-Binding Proteins, Energy Metabolism, Food, Forecasting, Gene Expression Regulation, Humans, Ion Channels, Membrane Proteins, Mitochondria, Transcription Factors, Transcription, Genetic, Trans-Activators, Muscle, Skeletal, Mitochondrial Proteins, Nuclear Respiratory Factors, GA-Binding Protein Transcription Factor
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