Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

HOW CELLS RESPOND TO INTERFERONS

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,741

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374

Unresponsiveness of MyD88-deficient mice to endotoxin.

Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C.-Q., Ghosh, S., & Janeway, C. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80136-7 · Cited by 1,783

Influenza-virus-induced signaling cascades: targets for antiviral therapy?

Ludwig, S., Planz, O., Pleschka, S., & Wolff, T. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)00010-2 · Cited by 170

Distinct Induction Patterns and Functions of Two Closely Related Interferon-inducible Human Genes, ISG54 and ISG56

Terenzi, F., Hui, D. J., Merrick, W. C., & Sen, G. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605771200 · Cited by 177

Nod2: The intestinal gate keeper

Nabhani, Z. A., Dietrich, G., Hugot, J., & Barreau, F. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006177 · Cited by 178

Innate immune receptors in platelets and platelet-leukocyte interactions

Dib, P. R. B., Quirino-Teixeira, A. C., Merij, L. B., Pinheiro, M. B. M., Rozini, S. V., Andrade, F. B., & Hottz, E. D. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0620-701r · Cited by 174

Translational Mini-Review Series on Toll-like Receptors: Networks regulated by Toll-like receptors mediate innate and adaptive immunity

Parker, L. C., Prince, L. R., & Sabroe, I. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03203.x · Cited by 172

Effects of viral respiratory infections on lung development and childhood asthma

Gern, J. E., Rosenthal, L. A., Sorkness, R. L., & Lemanske, R. F. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.01.057 · Cited by 169

A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways

Sato, S. (2002) · International Immunology · doi:10.1093/intimm/dxf046 · Cited by 167

Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKε

Breiman, A., Grandvaux, N., Lin, R., Ottone, C., Akira, S., Yoneyama, M., Fujita, T., Hiscott, J. B., & MEURS, E. F. (2005) · Journal of Virology · doi:10.1128/jvi.79.7.3969-3978.2005 · Cited by 168

Imiquimod: modes of action

Sauder, D. N. (2003) · British Journal of Dermatology · doi:10.1046/j.0366-077x.2003.05628.x · Cited by 174

Hepatitis A virus: Host interactions, molecular epidemiology and evolution

Vaughan, G., Rossi, L. M. G., Forbi, J. C., de Paula, V. S., Purdy, M. A., Xia, G., & Khudyakov, Y. E. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.10.023 · Cited by 174

Signatures of positive selection in Toll-like receptor (TLR) genes in mammals

Areal, H., Abrantes, J., & Esteves, P. J. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-368 · Cited by 167

How important are Toll‐like receptors for antimicrobial responses?

Carpenter, S., & O'Neill, L. A. J. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00965.x · Cited by 182

A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus

Shi, Z., Cai, Z., Sanchez, A., Zhang, T., Wen, S., Wang, J., Yang, J., Fu, S., & Zhang, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159590 · Cited by 166

Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response

Swanson, C. L., Wilson, T. J., Strauch, P., Colonna, M., Pelanda, R., & Torres, R. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092695 · Cited by 162

Biology of Toll receptors: lessons from insects and mammals

Imler, J., & Zheng, L. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403160 · Cited by 173

Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells

Aksoy, E., Zouain, C. S., Vanhoutte, F., Fontaine, J., Pavelka, N., Thiéblemont, N., Willems, F., Ricciardi‐Castagnoli, P., Goldman, M., Capron, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411223200 · Cited by 166

Inhibition of HDAC8 and HDAC9 by microbial short-chain fatty acids breaks immune tolerance of the epidermis to TLR ligands

Sanford, J. A., Zhang, L.-J., Williams, M. R., Gangoiti, J. A., Huang, C.-M., & Gallo, R. L. (2016) · Science Immunology · doi:10.1126/sciimmunol.aah4609 · Cited by 166

Role of TLR9 in Anti-Nucleosome and Anti-DNA Antibody Production in lpr Mutation-Induced Murine Lupus

Lartigue, A., Courville, P., Auquit, I., François, A., Arnoult, C., Tron, F., Gilbert, D., & Musette, P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.1349 · Cited by 165

Intracellular Pathogen Detection by RIG-I-Like Receptors

Dixit, E., & Kagan, J. C. (2013) · Advances in immunology · doi:10.1016/b978-0-12-410524-9.00004-9 · Cited by 172

A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses

Neerincx, A., Lautz, K., Menning, M., Kremmer, E., Zigrino, P., Hösel, M., Büning, H., Schwarzenbacher, R., & Kufer, T. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109736 · Cited by 164

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

Koerner, J., Horvath, D. J., Herrmann, V. L., MacKerracher, A., Gander, B. A., Yagita∥, H., Rohayem, J., & Groettrup, M. (2021) · Nature Communications · doi:10.1038/s41467-021-23244-3 · Cited by 169

Selective Impairments in Dendritic Cell-Associated Function Distinguish Hepatitis C Virus and HIV Infection

Anthony, D. D., Yonkers, N. L., Post, A. B., Asaad, R. J., Heinzel, F. P., Lederman, M. M., Lehmann, P., & Valdez, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4907 · Cited by 165

Determinants of interferon-stimulated gene induction by RNAi vectors

Kaeser-Pebernard, S., & Iggo, R. D. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07202001.x · Cited by 165

Principles of intracellular viral recognition

Saito, T., & Gale, M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.11.003 · Cited by 166

Human Toll‐like receptor‐dependent induction of interferons in protective immunity to viruses

Zhang, S., Jouanguy, E., Sancho‐Shimizu, V., von Bernuth, H., Yang, K., Abel, L., Pïcard, C., Puel, A., & Casanova, J. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00564.x · Cited by 171

Myeloid Differentiation Factor 88–Dependent and –Independent Pathways in Toll‐Like Receptor Signaling

Akira, S., & Hoshino, K. (2003) · The Journal of Infectious Diseases · doi:10.1086/374749 · Cited by 170

Toll-like receptors in the depressed and suicide brain

Pandey, G. N., Rizavi, H. S., Ren, X., Bhaumik, R., & Dwivedi, Y. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.021 · Cited by 164

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

Horiguchi, H., Loftus, T. J., Hawkins, R. B., Raymond, S. L., Stortz, J. A., Hollen, M. K., Weiss, B. P., Miller, E. S., Bihorac, A., Larson, S. D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00595 · Cited by 164

Toll-like receptor expression in normal ovary and ovarian tumors

Zhou, M., McFarland-Mancini, M. M., Funk, H. M., Husseinzadeh, N., Mounajjed, T., & Drew, A. F. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0650-y · Cited by 164

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Estornes, Y., Toscano, F., Virard, F., Jacquemin, G., Pierrot, A., Vanbervliet, B., Bonnin, M., Lalaoui, N., Mercier‐Gouy, P., Pachéco, Y., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.22 · Cited by 164

Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors

Rožková, D., Horváth, R., Bartůňková, J., & Špíšek, R. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.04.567 · Cited by 164

Direct Costimulatory Effect of TLR3 Ligand Poly(I:C) on Human γδ T Lymphocytes

Wesch, D., Beetz, S., Oberg, H., Marget, M., Krengel, K., & Kabelitz, D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1348 · Cited by 168

Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors

Jégo, G., Bataille, R., Geffroy-Luseau, A., Descamps, G., & Pellat‐Deceunynck, C. (2006) · Leukemia · doi:10.1038/sj.leu.2404226 · Cited by 163

Role of MyD88 in Diminished Tumor Necrosis Factor Alpha Production by Newborn Mononuclear Cells in Response to Lipopolysaccharide

Yan, S. R., Qing, G., Byers, D. M., Stadnyk, A. W., Al‐Hertani, W., & Bortolussi, R. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.3.1223-1229.2004 · Cited by 163

Extracellular miRNA: A Collision of Two Paradigms

Turchinovich, A. A., Tonevitsky, A., & Burwinkel, B. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.08.004 · Cited by 168

TLR7: A new sensor of viral infection

Crozat, K., & Beutler, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401347101 · Cited by 163

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

Rigby, R. E., Webb, L. M., Mackenzie, K. J., Li, Y., Leitch, A., Reijns, M. A. M., Lundie, R. J., Revuelta, A., Davidson, D. J., Diebold, S. S., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386117 · Cited by 169

Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions

Ballarín-González, B., & Howard, K. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.004 · Cited by 164

Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

Hui, C. W., St-Pierre, A., Hajj, H. E., Remy, Y., Hébert, S. S., Luheshi, G. N., Srivastava, L. K., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00013 · Cited by 166

Toll-Like Receptors and Their Function in Innate and Adaptive Immunity

Heine, H., & Lien, E. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000069517 · Cited by 162

X-ray crystal structure of IRF-3 and its functional implications

Takahasi, K., Suzuki, N. N., Horiuchi, M., Mori, M., Suhara, W., Okabe, Y., Fukuhara, Y., Terasawa, H., Akira, S., Fujita, T., et al. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb1001 · Cited by 162

MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

Wang, J. P., Cerny, A., Asher, D. R., Kurt‐Jones, E. A., Bronson, R. T., & Finberg, R. W. (2009) · Journal of Virology · doi:10.1128/jvi.00631-09 · Cited by 161

New paradigms in inflammatory signaling in vascular endothelial cells

Xiao, L., Liu, Y., & Wang, N. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00182.2013 · Cited by 166

Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity

Way, S. S., Thompson, L. J., Lopes, J. E., Hajjar, A. M., Kollmann, T. R., Freitag, N. E., & Wilson, C. B. (2004) · Cellular Microbiology · doi:10.1046/j.1462-5822.2004.00360.x · Cited by 161

Modulation of Toll?interleukin 1 receptor mediated signaling

Li, X., & Qin, J. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0622-4 · Cited by 159

Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors

Christensen, S. R., & Shlomchik, M. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2006.12.005 · Cited by 159

TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease

Mifsud, E. J., Tan, A. C. L., & Jackson, D. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00079 · Cited by 163

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

Paone, A., Starace, D., Galli, R., Padula, F., De Cesaris, P., Filippini, A., Ziparo, E., & Riccioli, A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn149 · Cited by 160

From periphery to center stage: 50 years of advancements in innate immunity

Carpenter, S. B., & O'Neill, L. A. J. (2024) · Cell · doi:10.1016/j.cell.2024.03.036 · Cited by 171

Host defense function of the airway epithelium in health and disease: clinical background

Message, S. D., & Johnston, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703315 · Cited by 159

Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties

Sun, B., Robertsen, B., Wang, Z., & Liu, B. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.10.001 · Cited by 161

BVDV and innate immunity

Peterhans, E., Jungi, T. W., & Schweizer, M. (2003) · Biologicals · doi:10.1016/s1045-1056(03)00024-1 · Cited by 158

Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane

Triantafilou, M., Morath, S., Mackie, A. R., Härtung, T., & Triantafilou, K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01270 · Cited by 158

Viral Determinants of Resistance to Treatment in Patients with Hepatitis C

Wohnsland, A., Hofmann, W. P., & Sarrazin, C. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00010-06 · Cited by 158

Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells

Ibeagha-Awemu, E. M., Lee, J., Ibeagha, A. E., Bannerman, D. D., Paape, M. J., & Zhao, X. (2007) · Veterinary Research · doi:10.1051/vetres:2007047 · Cited by 158

Natural type I interferon-producing cells as a link between innate and adaptive immunity

Kadowaki, N., & Liu, Y.-J. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00751-6 · Cited by 164

Novel functions of proteins encoded by viral stress-inducible genes

Sarkar, S. N., & Sen, G. C. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.07.007 · Cited by 160

IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses

Schellack, C., Prinz, K., Egyed, A., Fritz, J. H., Wittmann, B., Ginzler, M., Swatosch, G., Zauner, W., Kast, C. E., Akira, S., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.03.071 · Cited by 158

Danger‐associated molecular patterns ( DAMPs ) in acute lung injury

Tolle, L. B., & Standiford, T. J. (2013) · The Journal of Pathology · doi:10.1002/path.4124 · Cited by 157

No Love Lost Between Viruses and Interferons

Fensterl, V., Chattopadhyay, S., & Sen, G. C. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-055249 · Cited by 167

Toll-like Receptor 3 and STAT-1 Contribute to Double-stranded RNA+ Interferon-γ-induced Apoptosis in Primary Pancreatic β-Cells

Rasschaert, J., Ladrière, L., Urbain, M., Doğusan, Z., Katabua, B., Sato, S., Akira, S., Gysemans, C. A., Mathieu, C., & Eizirik, D. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502213200 · Cited by 157

Nucleic acid-binding polymers as anti-inflammatory agents

Lee, J., Sohn, J. W., Zhang, Y., Leong, K. W., Pisetsky, D. S., & Sullenger, B. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105777108 · Cited by 155

Role of Extracellular RNA and TLR3‐Trif Signaling in Myocardial Ischemia–Reperfusion Injury

Chen, C., Feng, Y., Zou, L., Wang, L. L., Chen, H. H., Cai, J., Xu, J., Sosnovik, D. E., & Chao, W. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000683 · Cited by 157

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

Ohto, U., Ishida, H., Shibata, T., Sato, R., Miyake, K., & Shimizu, T. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.013 · Cited by 159

SIKE is an IKKε/TBK1‐associated suppressor of TLR3‐ and virus‐triggered IRF‐3 activation pathways

Huang, J., Liu, T., Xu, L., Chen, D., Zhai, Z., & Shu, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600863 · Cited by 155

Natural endogenous adjuvants

Rock, K. L., Hearn, A. R., Chen, C., & Shi, Y. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-004-0173-3 · Cited by 158

The role of Toll-like receptor 2 in microbial disease and immunity

Wetzler, L. M. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00201-9 · Cited by 157

TLR3‐mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling mechanisms of TLR3‐induced IP‐10 and IL‐8 gene expression

Park, C., Lee, S., Cho, I., Lee, H. K., Kim, D., Choi, S., Oh, S. B., Park, K., Kim, J. S., & Lee, S. J. (2005) · Glia · doi:10.1002/glia.20278 · Cited by 159

Signalling of Toll-Like Receptors

Brikos, C., & O'Neill, L. A. J. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72167-3_2 · Cited by 157

Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll‐like receptor‐2‐dependent mechanism

Weiss, G., Rasmussen, S., Zeuthen, L., Nielsen, B. N., Jarmer, H. Ø., Jespersen, L., & Frøkiær, H. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03301.x · Cited by 156

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

Uzri, D., & Gehrke, L. (2009) · Journal of Virology · doi:10.1128/jvi.02449-08 · Cited by 155

Molecular and Cellular Basis of Microflora-Host Interactions1,

Winkler, P., Ghadimi, D., Schrezenmeir, J., & Kraehenbühl, J.-P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.756s · Cited by 158

Mucosal vaccine delivery: Current state and a pediatric perspective

Shakya, A. K., Chowdhury, M. Y. E., Tao, W., & Gill, H. S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.014 · Cited by 158

Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma

Song, H., Huang, P., Niu, J., Shi, G., Zhang, C., Kong, D., & Wang, W. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.004 · Cited by 158

A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications

Qin, F., Xia, F., Chen, H., Cui, B., Feng, Y., Zhang, P., Chen, J., & Luo, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.633776 · Cited by 167

No Longer an Innocent Bystander: Epithelial Toll-Like Receptor Signaling in the Development of Mucosal Inflammation

Gribar, S. C., Richardson, W. M., Sodhi, C. P., & Hackam, D. J. (2008) · Molecular Medicine · doi:10.2119/2008-00035.gribar · Cited by 156

Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems

Lundberg, A. M., Drexler, S. K., Monaco, C. G., Williams, L. M., Sacre, S. M., Feldmann, M., & Foxwell, B. M. J. (2007) · Blood · doi:10.1182/blood-2007-02-072934 · Cited by 155

Role of Toll‐like receptors in costimulating cytotoxic T cell responses

Schwarz, K., Storni, T., Manolova, V., Didierlaurent, A. M., Sirard, J., Röthlisberger, P., & Bachmann, M. F. (2003) · European Journal of Immunology · doi:10.1002/eji.200323919 · Cited by 155

Human Rhinovirus Infection Induces Airway Epithelial Cell Production of Human β-Defensin 2 Both In Vitro and In Vivo

Proud, D., Sanders, S. P., & Wiehler, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4637 · Cited by 154

Trial Watch

Vacchelli, E., Eggermont, A. M. M., Sautès‐Fridman, C., Galon, J., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.25238 · Cited by 160

Effects of Single Nucleotide Polymorphisms on Toll-like Receptor 3 Activity and Expression in Cultured Cells

Ranjith-Kumar, C. T., Miller, W. R., Sun, J., Xiong, J., Santos, J., Yarbrough, I., Lamb, R. J., Mills, J. K., Duffy, K. E., Hoose, S. A., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700209200 · Cited by 154

Novel Role of Toll-Like Receptor 3 in Hepatitis C-Associated Glomerulonephritis

Wörnle, M., Schmid, H., Banas, B., Merkle, M., Henger, A., von Roeder, M., Blattner, S. M., Bock, E., Kretzler, M., Gröne, H., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050491 · Cited by 152

MyD88 Plays a Unique Role in Host Defense but Not Arthritis Development in Lyme Disease

Bolz, D. D., Sundsbak, R. S., Ma, Y., Akira, S., Kirschning, C. J., Zachary, J. F., Weis, J. H., & Weis, J. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.2003 · Cited by 155

Adaptor usage and Toll‐like receptor signaling specificity

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Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells

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Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

O'Neill, L. A. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02222-6 · Cited by 154

Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen recognition and signal transduction

Hippenstiel, S., Opitz, B., Schmeck, B., & Suttorp, N. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-97 · Cited by 158

Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity

Bourquin, C., Anz, D., Zwiorek, K., Lanz, A.-L., Fuchs, S. P., Weigel, S., Wurzenberger, C., von der Borch, P., Golić, M., Moder, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.2990 · Cited by 152

Wound Healing Is Impaired in MyD88-Deficient Mice

Macedo, L., Pinhal‐Enfield, G., Alshits, V., Elson, G., Cronstein, B. N., & Leibovich, S. J. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061048 · Cited by 158

Interferon and cytokine responses to SARS-coronavirus infection

Thiel, V., & Weber, F. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.01.001 · Cited by 150

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease

Antonczyk, A., Krist, B., Sajek, M., Sekrecka, A., Piaszyk-Borychowska, A., Plens-Gałąska, M., Wesoły, J., & Bluyssen, H. A. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01176 · Cited by 162

Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages

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Messenger RNA-based vaccines

Pascolo, S. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.8.1285 · Cited by 152

Antiviral immunity in crustaceans

Liu, H., Söderhäll, K., & Jiravanichpaisal, P. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.02.009 · Cited by 152

Immune Adjuvant Effect of Molecularly-defined Toll-Like Receptor Ligands

Toussi, D. N., & Massari, P. (2014) · Vaccines · doi:10.3390/vaccines2020323 · Cited by 161

Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

Saenz, S. A., Noti, M., & Artis, D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.09.001 · Cited by 152

Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood

Wit, D. D., Tonon, S., Olislagers, V., Goriely, S., Boutriaux, M., Goldman, M., & Willems, F. (2003) · Journal of Autoimmunity · doi:10.1016/j.jaut.2003.08.003 · Cited by 152

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon

Mutz, P., Metz, P., Lempp, F. A., Bender, S., Qu, B., Schöneweis, K., Seitz, S., Tu, T., Restuccia, A., Frankish, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.044 · Cited by 152

Distinct changes in endosomal composition promote NLRP3 inflammasome activation

Zhang, Z., Venditti, R., Li, R., Liu, Z., Vivot, K., Schürmann, A., Bonifacino, J. S., Matteis, M. A. D., & Ricci, R. (2022) · Nature Immunology · doi:10.1038/s41590-022-01355-3 · Cited by 155

Expression of functional Toll-like receptor 2 on human epidermal keratinocytes

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TLR3 Tolls for dsRNA

(2001) · Science Signaling · doi:10.1126/scisignal.1052001tw389

Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

Jiang, Z., Zamanian-Daryoush, M., Nie, H., Silva, A. M., Williams, B. R. G., & Li, X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300562200 · Cited by 300

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

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Immunology highlights from the recent literature

(2001) · Nature Immunology · doi:10.1038/ni1101-996

Transcriptional signaling by double-stranded RNA: role of TLR3

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