Innate antimicrobial peptide protects the skin from invasive bacterial infection

Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

Zasloff, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5449 · Cited by 2,305

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809

Defensins. Natural peptide antibiotics of human neutrophils.

Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S. L., Daher, K. A., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

Yang, D., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J., Wooters, J., Oppenheim, J. J., & Chertov, O. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1069 · Cited by 1,238

Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., ZASLOFF, M. A., & Wilson, J. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81895-4 · Cited by 1,077

Complete genome sequence of an M1 strain of Streptococcus pyogenes

Ferretti, J. J., McShan, W. M., Ajdić, D., Savić, D. J., Savić, G., Lyon, K., Primeaux, C., Sezate, S. A., Suvorov, A. N., Kenton, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071559398 · Cited by 936

The Human Gene FALL39 and Processing of the Cathelin Precursor to the Antibacterial Peptide LL‐37 in Granulocytes

Gudmundsson, G. H., Agerberth, B., Odeberg, J., Bergman, T., Olsson, B., & Salcedo, R. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0325z.x · Cited by 579

Cutaneous Injury Induces the Release of Cathelicidin Anti-Microbial Peptides Active Against Group A Streptococcus

Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., & Gallo, R. L. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01340.x · Cited by 567

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

Chertov, O., Michiel, D. F., Xu, L., Wang, J., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., & Oppenheim, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2935 · Cited by 548

Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator

Islam, D., Bandholtz, L., Nilsson, J., Wigzell, H., Christensson, B., Agerberth, B., & Gudmundsson, G. H. (2001) · Nature Medicine · doi:10.1038/84627 · Cited by 429

Antimicrobial peptides of multicellular organisms

Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457

Wound repair and regeneration: Mechanisms, signaling, and translation

Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562

Defensins: antimicrobial peptides of innate immunity

Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066

Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis

Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

Mahlapuu, M., Håkansson, J., Ringstad, L., & Björn, C. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00194 · Cited by 2,020

Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression

Wang, T. T., Nestel, F. P., Bourdeau, V., Nagai, Y., Wang, Q., Liao, J. L., Tavera-Mendoza, L. E., Lin, R., Hanrahan, J. W., Mader, S., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.2909 · Cited by 1,661

Antimicrobial host defence peptides: functions and clinical potential

Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

Lai, Y., & Gallo, R. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2008.12.003 · Cited by 1,322

Antibacterial peptides: basic facts and emerging concepts

Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,171

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D 3

Gombart, A. F., Borregaard, N., & Koeffler, H. P. (2005) · The FASEB Journal · doi:10.1096/fj.04-3284com · Cited by 1,145

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4680 · Cited by 1,095

The co-evolution of host cationic antimicrobial peptides and microbial resistance

Peschel, A., & Sahl, H. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1441 · Cited by 1,076

LL-37, the only human member of the cathelicidin family of antimicrobial peptides

Dürr, U. H. N., Sudheendra, U. S., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.030 · Cited by 1,049

Antimicrobial peptides

Zhang, L., & Gallo, R. L. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.017 · Cited by 1,074

A component of innate immunity prevents bacterial biofilm development

Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026

Cathelicidins, multifunctional peptides of the innate immunity

Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 1,020

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18

Koczulla, R., von Degenfeld, G., Kupatt, C., Krötz, F., Zahler, S., GLOE, T. R., Issbrücker, K., Unterberger, P., Zaiou, M., Lebherz, C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17545 · Cited by 880

Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea

Yamasaki, K., Nardo, A. D., Bardan, A., Murakami, M., Ohtake, T., Coda, A. B., Dorschner, R. A., Bonnart, C., Descargues, P., Hovnanian, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1616 · Cited by 864

Cationic host defense (antimicrobial) peptides

Brown, K. L., & Hancock, R. E. W. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.004 · Cited by 849

Alarmins: chemotactic activators of immune responses

Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781

Stratum Corneum Defensive Functions: An Integrated View

Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23668.x · Cited by 818

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765

Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

Liu, G. Y., Essex, A., Buchanan, J. T., Datta, V., Hoffman, H. M., Bastian, J. F., Fierer, J., & Nizet, V. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050846 · Cited by 752

Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes

Nomura, I., Goleva, E., Howell, M. D., Hamid, Q., Ong, P. Y., Hall, C. F., Darst, M. A., Gao, B., Boguniewicz, M., Travers, J. B., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3262 · Cited by 729

Mechanisms and consequences of bacterial resistance to antimicrobial peptides

Andersson, D. I., Hughes, D., & Kubicek-Sutherland, J. Z. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.04.002 · Cited by 718

The future challenges facing the development of new antimicrobial drugs

Coates, A. R. M., Hu, Y., Bax, R. P., & Page, C. P. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd940 · Cited by 705

HIF-1α expression regulates the bactericidal capacity of phagocytes

Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A. L., Theodorakis, E. A., Gallo, R. L., Hurtado‐Ziola, N., Nizet, V., & Johnson, R. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23865 · Cited by 715

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D–dependent mechanism

Schauber, J., Dorschner, R. A., Coda, A. B., Büchau, A. S., Liu, P. T., Kiken, D. A., Helfrich, Y. R., Kang, S., Elalieh, H. Z., Steinmeyer, A., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30142 · Cited by 695

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection

Chromek, M., Slamová, Z., Bergman, P., Kovács, L., Podracká, L., Ehrén, I., Hökfelt, T., Gudmundsson, G. H., Gallo, R. L., Agerberth, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1407 · Cited by 652

Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection

Gläser, R., Harder, J., Lange, H., Bartels, J., Christophers, E., & Schröder, J.-M. (2005) · Nature Immunology · doi:10.1038/ni1142 · Cited by 651

Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus

Serra, R., Grande, R., Butrico, L., Rossi, A., Settimio, U. F., Caroleo, B., Amato, B., Gallelli, L., & de Franciscis, S. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1023291 · Cited by 674

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Pessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 689

Multifunctional cationic host defence peptides and their clinical applications

Yeung, A. T. Y., Gellatly, S. L., & Hancock, R. E. W. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0710-x · Cited by 613

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

Hilchie, A. L., Wuerth, K. C., & Hancock, R. E. W. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1393 · Cited by 618

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens

Bals, R., & Hiemstra, P. S. (2004) · European Respiratory Journal · doi:10.1183/09031936.03.00098803 · Cited by 589

The Cathelicidin Anti-Microbial Peptide LL-37 is Involved in Re-Epithelialization of Human Skin Wounds and is Lacking in Chronic Ulcer Epithelium

Heilborn, J. D., Nilsson, M. F., Sørensen, O., Ståhle-Bäckdahl, M., Kratz, G., Weber, G., & Borregaard, N. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12069.x · Cited by 572

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572

Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase

Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U., Xu, W., Klevit, R. E., Moual, H. L., & Miller, S. I. (2005) · Cell · doi:10.1016/j.cell.2005.05.030 · Cited by 554

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

Vandamme, D., Landuyt, B., Luyten, W. H. M. L., & Schoofs, L. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.11.009 · Cited by 592

Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus -Derived Proteinases

Sieprawska‐Lupa, M., Mydel, P. M., Krawczyk, K., Wójcik, K., Puklo, M., Lupa, B., Suder, P., Silberring, J., Reed, M. S., Pohl, J., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.12.4673-4679.2004 · Cited by 567

Modulating immunity as a therapy for bacterial infections

Hancock, R. E. W., Nijnik, A., & Philpott, D. J. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2745 · Cited by 558

Human Antimicrobial Peptides and Proteins

Wang, G. (2014) · Pharmaceuticals · doi:10.3390/ph7050545 · Cited by 545

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

Malhotra, S., Hayes, D., & Wozniak, D. J. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00138-18 · Cited by 542

Bacterial strategies for overcoming host innate and adaptive immune responses

Hornef, M. W., Wick, M. J., Rhen, M., & Normark, S. J. (2002) · Nature Immunology · doi:10.1038/ni1102-1033 · Cited by 505

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study

Pütsep, K., Carlsson, G., Boman, H. G., & Andersson, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11201-3 · Cited by 499

Structures of Human Host Defense Cathelicidin LL-37 and Its Smallest Antimicrobial Peptide KR-12 in Lipid Micelles

Wang, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805533200 · Cited by 483

Fmoc-modified amino acids and short peptides: simple bio-inspired building blocks for the fabrication of functional materials

Tao, K., Levin, A., Adler‐Abramovich, L., & Gazit, E. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00889a · Cited by 483

Antimicrobial peptides and the skin immune defense system

Schauber, J., & Gallo, R. L. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.027 · Cited by 483

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471

Kallikrein‐mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

Yamasaki, K., Schauber, J., Coda, A. B., Lin, H. C., Dorschner, R. A., Schechter, N. M., Bonnart, C., Descargues, P., Hovnanian, A., & Gallo, R. L. (2006) · The FASEB Journal · doi:10.1096/fj.06-6075com · Cited by 476

Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections

Mookherjee, N., & Hancock, R. E. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6475-6 · Cited by 470

How do bacteria resist human antimicrobial peptides?

Peschel, A. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02333-8 · Cited by 462

Dermatan sulfate: new functions from an old glycosaminoglycan

Trowbridge, J. M., & Gallo, R. L. (2002) · Glycobiology · doi:10.1093/glycob/cwf066 · Cited by 459

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

Döring, Y., Manthey, H. D., Drechsler, M. D., Lievens, D., Megens, R. T. A., Soehnlein, O., Busch, M., Manca, M., Koenen, R. R., Pelisek, J., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.046755 · Cited by 469

The Vitamin D–Antimicrobial Peptide Pathway and its Role in Protection Against Infection

Gombart, A. F. (2009) · Future Microbiology · doi:10.2217/fmb.09.87 · Cited by 474

Activation of TLR2 by a Small Molecule Produced by Staphylococcus epidermidis Increases Antimicrobial Defense against Bacterial Skin Infections

Lai, Y., Cogen, A. L., Radek, K. A., Park, H. J., MacLeod, D. T., Leichtle, A., Ryan, A. F., Di Nardo, A., & Gallo, R. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.123 · Cited by 446

The skin barrier as an innate immune element

Elias, P. M. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0060-9 · Cited by 440

Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL‐37

Schmidtchen, A., Frick, I.-M., Andersson, E., Tapper, H., & Björck, L. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03146.x · Cited by 440

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3

Wu, Z., Hoover, D. M., Yang, D., Boulègue, C., Santamaria, F., Oppenheim, J. J., Lubkowski, J. T., & Lu, W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533186100 · Cited by 439

Selective Antimicrobial Action Is Provided by Phenol-Soluble Modulins Derived from Staphylococcus epidermidis, a Normal Resident of the Skin

Cogen, A. L., Yamasaki, K., Sanchez, K. M., Dorschner, R. A., Lai, Y., MacLeod, D. T., Torpey, J. W., Otto, M., Nizet, V., Kim, J. E., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.243 · Cited by 432

Cathelicidins - a family of multifunctional antimicrobial peptides

Bals, R., & Wilson, J. M. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-2186-9 · Cited by 427

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

Kahlenberg, J. M., & Kaplan, M. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302005 · Cited by 444

The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization

Davidson, D. J., Currie, A. J., Reid, G. S. D., Bowdish, D. M. E., MacDonald, K. L., Rebecca, C., Hancock, R. E. W., & Speert, D. P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1146 · Cited by 440

Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cells

Ouhara, K., Komatsuzawa, H., Yamada, S., Shiba, H., Fujiwara, T., Ohara, M., Sayama, K., Hashimoto, K., Kurihara, H., & Sugai, M. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki103 · Cited by 427

A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1β Processing and Release

Elssner, A., Duncan, M., Gavrilin, M. A., & Wewers, M. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4987 · Cited by 425

The Role of Cathelicidins in the Innate Host Defenses of Mammals

Zanetti, M. (2005) · Current Issues in Molecular Biology · doi:10.21775/cimb.007.179 · Cited by 414

Roles of antimicrobial peptides such as defensins in innate and adaptive immunity

Oppenheim, J. J., Biragyn, A., Kwak, L. W., & Yang, D. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.suppl_2.ii17 · Cited by 407

Cutting Edge: Mast Cell Antimicrobial Activity Is Mediated by Expression of Cathelicidin Antimicrobial Peptide

Nardo, A. D., Vitiello, A., & Gallo, R. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2274 · Cited by 415

Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

Subramanian, H., Gupta, K., & Ali, H. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.04.051 · Cited by 401

Antimicrobial Peptides: Old Molecules with New Ideas

Nakatsuji, T., & Gallo, R. L. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.387 · Cited by 411

The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor

Tjabringa, G. S., Aarbiou, J., Ninaber, D. K., Drijfhout, J. W., Sørensen, O. E., Borregaard, N., Rabe, K. F., & Hiemstra, P. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6690 · Cited by 398

Microbial Symbiosis with the Innate Immune Defense System of the Skin

Gallo, R. L., & Nakatsuji, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.182 · Cited by 387

Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways

Schauber, J. (2003) · Gut · doi:10.1136/gut.52.5.735 · Cited by 383

Antimicrobial peptides

Izadpanah, A., & Gallo, R. L. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.08.026 · Cited by 393

What is new in the pathophysiology of acne, an overview

Dréno, B. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14374 · Cited by 395

Impact of LL-37 on anti-infective immunity

Bowdish, D. M. E., Davidson, D. J., Lau, Y. E., Lee, K. C. L., Scott, M. G., & Hancock, R. E. W. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704380 · Cited by 382

A Model of Bacterial Intestinal Infections in Drosophila melanogaster

Nehme, N. T., Liégeois, S., Kele, B., Giammarinaro, P., Pradel, E., Hoffmann, J. A., Ewbank, J. J., & Ferrandon, D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030173 · Cited by 358

Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors

Sørensen, O. E., Cowland, J. B., Theilgaard‐Mönch, K., Liu, L., Ganz, T., & Borregaard, N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5583 · Cited by 373

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons

Gregorio, J., Meller, S., Conrad, C., Di Nardo, A., Homey, B., Lauerma, A., Arai, N., Gallo, R. L., DiGiovanni, J., & Gilliet, M. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20101102 · Cited by 367

Biology and Biomarkers for Wound Healing

Lindley, L. E., Stojadinović, O., Pastar, I., & Tomic‐Canic, M. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002682 · Cited by 379

Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression

Nakatsuji, T., Chen, T. H., Two, A. M., Chun, K., Narala, S., Geha, R. S., Hata, T. R., & Gallo, R. L. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.127 · Cited by 379

Constitutive immune mechanisms: mediators of host defence and immune regulation

Paludan, S. R., Pradeu, T., Masters, S. L., & Mogensen, T. H. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0391-5 · Cited by 388

Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37

Tokumaru, S., Sayama, K., Shirakata, Y., Komatsuzawa, H., Ouhara, K., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Nagai, H., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4662 · Cited by 367

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

Barlow, P. G., Svoboda, P., Mackellar, A., Nash, A. A., York, I. A., Pohl, J., Davidson, D. J., & Donis, R. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025333 · Cited by 369

Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene

Blandin, S. A., Moita, L. F., Köcher, T., Wilm, M. S., Kafatos, F. C., & Levashina, E. A. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf180 · Cited by 360

Fusobacterium nucleatumin Periodontal Health and Disease

Signat, B., Roques, C. G., Poulet, P. P., & Duffaut, D. (2011) · Current Issues in Molecular Biology · doi:10.21775/cimb.013.025 · Cited by 332

Applications of biological pores in nanomedicine, sensing, and nanoelectronics

Majd, S., Yusko, E. C., Billeh, Y. N., Macrae, M. X., Yang, J., & Mayer, M. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.05.002 · Cited by 325

Structure and function of the epidermal barrier

Wickett, R. R., & Visscher, M. O. (2006) · American Journal of Infection Control · doi:10.1016/j.ajic.2006.05.295 · Cited by 327

The Role of Antimicrobial Peptides in Innate Immunity

Ganz, T. (2003) · Integrative and Comparative Biology · doi:10.1093/icb/43.2.300 · Cited by 322

Antimicrobial Defense of the Intestine

Mukherjee, S., & Hooper, L. V. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.028 · Cited by 334

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

Zhang, K., Wang, S., Zhou, C., Cheng, L., Gao, X., Xie, X., Sun, J., Wang, H., Weir, M. D., Reynolds, M. A., et al. (2018) · Bone Research · doi:10.1038/s41413-018-0032-9 · Cited by 321

Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic

Raqib, R., Sarker, P., Bergman, P., Ara, G., Lindh, M., Sack, D. A., Islam, K., Gudmundsson, G. H., Andersson, J., & Agerberth, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602888103 · Cited by 317

Postsecretory Processing Generates Multiple Cathelicidins for Enhanced Topical Antimicrobial Defense

Murakami, M., López‐García, B., Braff, M. H., Dorschner, R. A., & Gallo, R. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3070 · Cited by 311

Antimicrobial Peptides

Koczulla, A. R., & Bals, R. (2003) · Drugs · doi:10.2165/00003495-200363040-00005 · Cited by 309

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

Sun, J., Furio, L., Mecheri, R., van der Does, A. M., Lundeberg, E., Saveanu, L., Chen, Y., van Endert, P., Agerberth, B., & Diana, J. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.013 · Cited by 292

Natural roles of antimicrobial peptides in microbes, plants and animals

Maróti, G., Kereszt, A., Kondorosi, É., & Mergaert, P. (2011) · Research in Microbiology · doi:10.1016/j.resmic.2011.02.005 · Cited by 298

Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses

Liu, P. T., Schenk, M., Walker, V. P., Dempsey, P. W., Kanchanapoomi, M., Wheelwright, M., Vazirnia, A., Zhang, X., Steinmeyer, A., Zügel, U., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005810 · Cited by 298

Can innate immunity be enhanced to treat microbial infections?

Finlay, B. B., & Hancock, R. E. W. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro908 · Cited by 296

Cutaneous Injury Induces the Release of Cathelicidin Anti-Microbial Peptides Active Against Group A Streptococcus

Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., & Gallo, R. L. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01340.x · Cited by 567

Keratinocyte Production of Cathelicidin Provides Direct Activity against Bacterial Skin Pathogens

Braff, M. H., Zaiou, M., Fierer, J., Nizet, V., & Gallo, R. L. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6771-6781.2005 · Cited by 162

Neonatal Skin in Mice and Humans Expresses Increased Levels of Antimicrobial Peptides: Innate Immunity During Development of the Adaptive Response

Dorschner, R. A., Lin, K. H., Murakami, M., & Gallo, R. L. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000057205.64451.b7 · Cited by 151

Cathelicidins and Innate Defense Against Invasive Bacterial Infection

Nizet, V., & Gallo, R. L. (2003) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540310015629 · Cited by 90

Mast Cell Cathelicidin Antimicrobial Peptide Prevents Invasive Group A Streptococcus Infection of the Skin

Nardo, A. D., Yamasaki, K., Dorschner, R. A., Lai, Y., & Gallo, R. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7565 · Cited by 130