The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Extending the lifespan of long-lived mice
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“There is overwhelming evidence that single gene mutations in nutrient-sensing pathways, such as insulin/insulin-like growth factor (IGF) signaling (Bartke et al., 2001) or the mechanistic target of rapamycin (mTOR) signaling pathways, extend lifespan and health span in invertebrates.”
From Metformin as a tool to target aging (2016) · cites this paper as Bartke et al., 2001
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“The lifespan and healthspan of invertebrates are extended by mutations in pathways such as the DAF-2, a gene that encodes for the IGF-1 pathway in the nematode Caenorhabditis elegans (C. elegans), or the mTOR signaling pathways that are linked to accelerating the aging process (60, 62–65).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [63]
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Cites
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Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436
Dwarf mice and the ageing process
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Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874
Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826
Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1
Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611
The Retardation of Aging by Caloric Restriction: Studies in Rodents and Primates
Weindruch, R. H. (1996) · Toxicologic Pathology · doi:10.1177/019262339602400618 · Cited by 268
Delayed Aging in Ames Dwarf Mice. Relationships to Endocrine Function and Body Size
Bartke, A. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48003-7_10 · Cited by 109
Harris, S. B., Gunion, M. W., Rosenthal, M. J., & Walford, R. L. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90053-1 · Cited by 81
Research works printed but not linked: 1
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Bartke, A., Darcy, J., & Yuan, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00018-x
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Landrus, M. (2018) · Advances in intelligent systems and computing · doi:10.1007/978-3-319-95588-9_3
Role of GH/IGF-I Deficiency in Aging
List, E. O. (2010) · Springer eBooks · doi:10.1007/978-3-642-11183-9_50
Generation and characterization of a pig model for Laron syndrome
Hinrichs, A. (2018) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.22856
Kim, H. (2008) · Corpus Université Laval (Université Laval)
Impact of physical activity on immune function and inflammation in the elderly
Bartlett, D. B. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Mouse Models and Genetics of Immunosenescence
Yu, Q., Sen, J. M., & Taub, D. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_3-1
Longevity as a complex genetic trait
Sutphin, G. L., & Korstanje, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00001-9
Mouse Models and Genetics of Immunosenescence
Yu, Q., Sen, J. M., & Taub, D. D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_3
Anti-Aging Medicine LiteratureWatch
(2002) · Rejuvenation Research · doi:10.1089/109454502317629363
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Lee, C. D., & Longo, V. D. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_27
(2014) · Elsevier eBooks · doi:10.1016/b978-1-907568-42-8.50016-2
Isolating the Direct Effects of Growth Hormone on Lifespan and MetabolismPreprint
Lasher, A. T., Liu, K., Fitch, M. P., & Sun, L. Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.18.613718
Broad Effects of Activation of Alcohol Dehydrogenase 1 on Healthspan ExtensionPreprint
Sukienik, A., Berhanu, S., Ghaddar, A., MacPhail, E., & O’Rourke, E. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.23.687054
Glebov, A. (2011) · Spectrum Research Repository (Concordia University)
Blood flow and angiogenesis: Major mechanisms mediating healthful longevity
Zhang, J., Vatner, D. E., Gad, A., Graham, R. M., & Vatner, S. F. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103037
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Hydrogen sulfide at the intersection of aging and type 2 diabetes: Mechanisms of metabolic rewiring
Cáliz‐Molina, M. Á., Pino-Pérez, I., Camacho-Cabrera, M., Hine, C., & Martín‐Montalvo, A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103251
Establishing a role for specific nutrients in Drosophila dietary restriction
Grandison, R. C. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Aging and Dietary Restriction: The Yeast Paradigm
Wei, M., Madia, F., de Cabo, R., & Longo, V. D. (2010) · Springer eBooks · doi:10.1007/978-90-481-8556-6_6
Metadata
- Authors
- Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S.
- Affiliations
- Southern Illinois University Carbondale (US)
- National Institutes of Health (US)
- University of Michigan (US)
- Corresponding author
- Bartke, Andrzej
- Venue
- Nature
- Published
- 2001-11-22
- Volume
- 414
- Issue
- 6862
- Pages
- 412-412
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1994357518
- Cited by
- 422
- References
- 11
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 5 · 2021: 15 · 2020: 11 · 2019: 15 · 2018: 20 · 2017: 9 · 2016: 9 · 2015: 18 · 2014: 14 · 2013: 19 · 2012: 12
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- Ames dwarf mice, lifespan extension, caloric restriction, PROP1, dietary restriction, aging mechanisms
- MeSH terms
- Animals, Energy Intake, Dwarfism, Female, Longevity, Male, Mice, Mutant Strains, Transcription Factors, Homeodomain Proteins, Mice
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