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Extending the lifespan of long-lived mice
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“The lifespan and healthspan of invertebrates are extended by mutations in pathways such as the DAF-2, a gene that encodes for the IGF-1 pathway in the nematode Caenorhabditis elegans (C. elegans), or the mTOR signaling pathways that are linked to accelerating the aging process (60, 62–65).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [63]
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“There is overwhelming evidence that single gene mutations in nutrient-sensing pathways, such as insulin/insulin-like growth factor (IGF) signaling (Bartke et al., 2001) or the mechanistic target of rapamycin (mTOR) signaling pathways, extend lifespan and health span in invertebrates.”
From Metformin as a tool to target aging (2016) · cites this paper as Bartke et al., 2001
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Metadata
- Authors
- Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S.
- Affiliations
- Southern Illinois University Carbondale (US)
- National Institutes of Health (US)
- University of Michigan (US)
- Corresponding author
- Bartke, Andrzej
- Venue
- Nature
- Published
- 2001-11-22
- Volume
- 414
- Issue
- 6862
- Pages
- 412-412
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1994357518
- Cited by
- 422
- References
- 11
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 5 · 2021: 15 · 2020: 11 · 2019: 15 · 2018: 20 · 2017: 9 · 2016: 9 · 2015: 18 · 2014: 14 · 2013: 19 · 2012: 12
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- Ames dwarf mice, lifespan extension, caloric restriction, PROP1, dietary restriction, aging mechanisms
- MeSH terms
- Animals, Energy Intake, Dwarfism, Female, Longevity, Male, Mice, Mutant Strains, Transcription Factors, Homeodomain Proteins, Mice
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