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Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1

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The Retardation of Aging by Caloric Restriction: Studies in Rodents and Primates

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Targeting the autophagy pathway for cancer chemoprevention

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Metabolic mystery: aging, obesity, diabetes, and the ventromedial hypothalamus

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Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

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Patterns and processes of human life history evolution

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Genetics and Pharmacology of Longevity

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Aging and TOR: interwoven in the fabric of life

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Insulin sensitivity in long-living Ames dwarf mice

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Growth and Aging

Miller, R. A., & Austad, S. N. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50022-4 · Cited by 34

Secrets of the lac Operon

Mobbs, C. V., Mastaitis, J. W., Zhang, M., Isoda, F., Cheng, H., & Yen, K. (2006) · KARGER eBooks · doi:10.1159/000096555 · Cited by 35

Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice

Argentino, D. P., Dominici, F. P., Muñoz, M. C., Al-Regaiey, K., Bartke, A., & Turyn, D. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.09.005 · Cited by 33

The Effects of Growth Hormone (GH) Treatment on GH and Insulin/IGF-1 Signaling in Long-Lived Ames Dwarf Mice

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Genetic cartography of longevity in humans and mice: Current landscape and horizons

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SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction

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Transcription‐blocking DNA damage in aging: a mechanism for hormesis

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Screening Candidate Longevity Therapeutics Using Gene-Expression Arrays

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Mechanisms of ageing: growth hormone, dietary restriction, and metformin

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Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration

Chujo, Y., Fujii, N., Okita, N., Konishi, T., Narita, T., Yamada, A., Haruyama, Y., Tashiro, K., Chiba, T., Shimokawa, I., et al. (2012) · AGE · doi:10.1007/s11357-012-9439-1 · Cited by 33

Extracellular RNA in aging

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The effect of different levels of dietary restriction on glucose homeostasis and metabolic memory

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Comparative cellular biogerontology: Primer and prospectus

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Effect of Nutritional Interventions on Longevity of Senior Cats

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Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity – Trade-Offs and Pace-Of-Life

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Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice

Gesing, A., Al-Regaiey, K., Bartke, A., & Masternak, M. M. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.08.010 · Cited by 30

Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

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Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic responses

Garratt, M. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-190067 · Cited by 30

DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice

Loniewska, M. M., Gupta, A., Bhatia, S., MacKay-Clackett, I., Jia, Z., & Wells, P. G. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101332 · Cited by 28

Effects of mild calorie restriction on reproduction, plasma parameters and hepatic gene expression in mice with altered GH/IGF-I axis

Rocha, J. S., Bonkowski, M. S., França, L. R., & Bartke, A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.02.001 · Cited by 29

Comparative Endocrinology of Aging and Longevity Regulation

Allard, J. B., & Duan, C. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00075 · Cited by 30

Solvable Senescence Model Showing a Mortality Plateau

Coe, J., Mao, Y. J., & Cates, M. E. (2002) · Physical Review Letters · doi:10.1103/physrevlett.89.288103 · Cited by 29

The Anti-Aging Sweepstakes: Catalase Runs for the ROSes

Miller, R. A. (2005) · Science · doi:10.1126/science.1114393 · Cited by 28

Hepatic Gene Expression Profile of Lipid Metabolism in Rats: Impact of Caloric Restriction and Growth Hormone/Insulin-Like Growth Factor-1 Suppression

Higami, Y., Tsuchiya, T., Chiba, T., Yamaza, H., Muraoka, I., Hirose, M., Komatsu, T., & Shimokawa, I. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1099 · Cited by 28

Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance

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Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan

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Genetic Suppression of GH-IGF-1 Activity, Combined with Lifelong Caloric Restriction, Prevents Age-Related Renal Damage and Prolongs the Life Span in Rats

Zha, Y., Taguchi, T., Nazneen, A., Shimokawa, I., Higami, Y., & Razzaque, M. S. (2008) · American Journal of Nephrology · doi:10.1159/000128607 · Cited by 27

Can flies shed light on our own age-related memory impairment?

Horiuchi, J., & Saitoe, M. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.10.001 · Cited by 28

Web-based analysis of the mouse transcriptome using Genevestigator

Laule, O., Hirsch‐Hoffmann, M., Hrúz, T., Gruissem, W., & Philip Zimmermann, B. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-311 · Cited by 27

Delayed Age-Associated Decrease in Growth Hormone Pulsatile Secretion and Increased Orexigenic Peptide Expression in the Lou C/Jall Rat

Kappeler, L., Zizzari, P., Alliot, J., Epelbaum, J., & Bluet-Pajot, M. (2005) · Neuroendocrinology · doi:10.1159/000083610 · Cited by 30

Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice

Ke, S., Mitchell, S. J., MacArthur, M. R., Kane, A. E., Sinclair, D. A., Venable, E. M., Chadaideh, K. S., Carmody, R. N., Grodstein, F., Mitchell, J. R., et al. (2021) · Nutrients · doi:10.3390/nu13093290 · Cited by 28

Extreme-longevity mutations orchestrate silencing of multiple signaling pathways

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Dietary restriction and aging in rodents: a current view on its molecular mechanisms.

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Do Ames dwarf and calorie-restricted mice share common effects on age-related pathology?

Ikeno, Y., Hubbard, G. B., Lee, S., Dube, S., Flores, L. C., Roman, M. G., & Bartke, A. (2013) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v3i0.20833 · Cited by 25

Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans

Yen, K., & Mobbs, C. V. (2009) · AGE · doi:10.1007/s11357-009-9110-7 · Cited by 25

Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort

Garratt, M., Nakagawa, S., & Simons, M. J. P. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx010 · Cited by 24

Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice

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Dietary Restriction and Life-Span

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Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice

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Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies

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Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice

Jiang, N., Cheng, C. J. A., Gelfond, J., Strong, R., Diaz, V., & Nelson, J. F. (2023) · Aging Cell · doi:10.1111/acel.13891 · Cited by 23

Electron Force Balance in Steady Collisionless-Driven Reconnection

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Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age

Hill, C. M., Arum, O., Boparai, R. K., Wang, F., Fang, Y., Sun, L. Y., Masternak, M. M., & Bartke, A. (2015) · AGE · doi:10.1007/s11357-015-9765-1 · Cited by 24

Aging and Cancer: Are Sirtuins the Link?

Rodríguez, R. M. A., & Fraga, M. F. (2010) · Future Oncology · doi:10.2217/fon.10.57 · Cited by 22

Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans

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Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

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Mechanisms of Dietary Restriction in Aging and Disease

Mobbs, C. V., Yen, K., & Hof, P. R. (2006) · Interdisciplinary topics in gerontology · doi:10.1159/isbn.978-3-318-01390-0 · Cited by 33

Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage

Dommerholt, M. B., Dionne, D. A., Hutchinson, D., Kruit, J. K., & Johnson, J. D. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0505 · Cited by 21

The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice

Wiesenborn, D. S., Menon, V., Zhi, X., Do, A., Gesing, A., Wang, Z., Bartke, A., Altomare, D. A., & Masternak, M. M. (2014) · Aging · doi:10.18632/aging.100700 · Cited by 21

Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?—a pathological point of view

Ikeno, Y., Lew, C. M., Cortez, L. A., Webb, C. R., Lee, S., & Hubbard, G. B. (2006) · AGE · doi:10.1007/s11357-006-9007-7 · Cited by 21

Effect of Leptin on Hypothalamic Gene Expression in Calorie-Restricted Rats

Komatsu, T., Chiba, T., Yamaza, H., To, K., Toyama, H., Higami, Y., & Shimokawa, I. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.890 · Cited by 20

Biological Effects of Calorie Restriction: Implications for Modification of Human Aging

Spindler, S. R. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_12 · Cited by 20

Molecular basis of ageing

Kaeberlein, M. R. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401066 · Cited by 20

Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age

Arum, O., Saleh, J. K., Boparai, R. K., Kopchick, J. J., Khardori, R. K., & Bartke, A. (2014) · AGE · doi:10.1007/s11357-014-9651-2 · Cited by 20

Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions

Chmielewski, P. P., Data, K., Strzelec, B., Farzaneh, M., Anbiyaiee, A., Zaheer, U., Uddin, S., Sheykhi-Sabzehpoush, M., Mozdziak, P. E., Zabel, M., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0280 · Cited by 25

Role of Insulin and Growth Hormone/Insulin-Like Growth Factor-I Signaling in Lifespan Extension: Rodent Longevity Models for Studying Aging and Calorie Restriction

Chiba, T., Yamaza, H., & Shimokawa, I. (2007) · Current Genomics · doi:10.2174/138920207783591726 · Cited by 20

Combined Effect of Gender and Caloric Restriction on Liver Proteomic Expression Profile

Valle, A., Silvestri, E., Moreno, M., Chambery, A., Oliver, J., Roca, P., & Goglia, F. (2008) · Journal of Proteome Research · doi:10.1021/pr800086t · Cited by 19

Targeting multiple hallmarks of mammalian aging with combinations of interventions

Panchin, A. Y., Ogmen, A., Blagodatski, A. S., Egorova, A., Batin, M., & Glinin, T. S. (2024) · Aging · doi:10.18632/aging.206078 · Cited by 22

Compromised respiratory adaptation and thermoregulation in aging and age-related diseases

Chan, S. L., Wei, Z., Chigurupati, S., & Tu, W. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.09.006 · Cited by 18

The Role of Ames Dwarfism and Calorie Restriction on Gut Microbiota

Wiesenborn, D. S., Gálvez, E. J. C., Spinel, L., Victoria, B., Allen, B. N., Schneider, A., Gesing, A., Al-Regaiey, K., Strowig, T., Schäfer, K., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz236 · Cited by 18

The Interconnections Between Somatic and Ovarian Aging in Murine Models

Schneider, A., Saccon, T. D., Garcia, D. N., Zanini, B. M., Isola, J. V. V., Hense, J. D., Rincón, J. A. A., Cavalcante, M. B., Mason, J. B., Stout, M. B., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa258 · Cited by 18

Influence of Adipokines on Metabolic Dysfunction and Aging

Park, S., & Shimokawa, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040873 · Cited by 20

Senescence in the ageing skin: a new focus on m TORC 1 and the lysosome

Smith, P., & Carroll, B. (2024) · FEBS Journal · doi:10.1111/febs.17281 · Cited by 18

Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion

Bartke, A., Evans, T. R., & Musters, C. J. M. (2019) · Aging · doi:10.18632/aging.102037 · Cited by 16

Dietary restriction in aging and longevity

Schmauck‐Medina, T., Lautrup, S., Francesco, A. D., Mitchell, S. J., Clemmensen, C., Partridge, L., Roth, G. S., Anderson, R. M., Mattison, J. A., de Cabo, R., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01091-5 · Cited by 18

microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling

Noureddine, S. A., Nie, J., Schneider, A., Menon, V., Fliesen, Z., Dhahbi, J. M., Victoria, B., Oyer, J. L., Robles-Carrillo, L. D., Nunes, A. D. D. C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213207120 · Cited by 17

Can Aging Be Programmed?

Mitteldorf, J. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918120106 · Cited by 16

IGF-I Signaling and Effects on Longevity

Holzenberger, M. (2011) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000325914 · Cited by 16

Age‐dependent mutational effects curtail the evolution of senescence by antagonistic pleiotropy

Moorad, J. A., & Hall, D. W. (2009) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2009.01849.x · Cited by 16

Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis

Hayashi, H., Yamaza, H., Komatsu, T., Park, S., Chiba, T., Higami, Y., Nagayasu, T., & Shimokawa, I. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.011 · Cited by 16

Eight Days of Water-Only Fasting Promotes Favorable Changes in the Functioning of the Urogenital System of Middle-Aged Healthy Men

Letkiewicz, S., Pilis, K., Ślęzak, A., Pilis, A., Pilis, W., Żychowska, M., & Langfort, J. (2020) · Nutrients · doi:10.3390/nu13010113 · Cited by 18

Combinatorial interventions in aging

Parkhitko, A. A., Filine, E., & Tatar, M. (2023) · Nature Aging · doi:10.1038/s43587-023-00489-9 · Cited by 17

Physiological and metabolic characteristics of novel double‐mutant female mice with targeted disruption of both growth hormone‐releasing hormone and growth hormone receptor

Icyuz, M., Zhang, F., Fitch, M. P., Joyner, M. R., Challa, A. K., & Sun, L. Y. (2021) · Aging Cell · doi:10.1111/acel.13339 · Cited by 14

Dietary Restriction, Hormesis, and Small Molecule Mimetics

Sinclair, D. A., & Howitz, K. T. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50006-6 · Cited by 15

Proteomic changes induced by longevity-promoting interventions in mice

Burns, A. R., Wiedrick, J. T., Feryn, A. B., Maes, M., Midha, M. K., Baxter, D. H., Morrone, S. R., Prokop, T. J., Kapil, C., Hoopmann, M. R., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00917-z · Cited by 14

A General Life History Theory for Effects of Caloric Restriction on Health Maintenance

Hou, C., Bolt, K., & Bergman, A. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-78 · Cited by 14

Aging of the Liver

Dhahbi, J. M., & Spindler, S. R. (2003) · Springer eBooks · doi:10.1007/978-94-017-0673-5_12 · Cited by 14

Thyroxine modifies the effects of growth hormone in Ames dwarf mice

Do, A., Menon, V., Zhi, X., Gesing, A., Wiesenborn, D. S., Spong, A., Sun, L. Y., Bartke, A., & Masternak, M. M. (2015) · Aging · doi:10.18632/aging.100739 · Cited by 13

Growth Hormone

Bonert, V. S., & Melmed, S. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804169-7.00004-0 · Cited by 14

Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice

Brown‐Borg, H. M., & Rakoczy, S. G. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.009 · Cited by 13

Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction

Chiba, T., Tsuchiya, T., Komatsu, T., Mori, R., Hayashi, H., Shimano, H., Spindler, S. R., & Shimokawa, I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.032 · Cited by 13

A genetic and genomic approach to identify longevity genes in mice

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