Cited by 366Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

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Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

Manabe, Toshiya, Renner, Pius, Nicoll, Roger A.·1992·Nature

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Abstract

Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.

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“Application of highosmolarity saline has been shown to cause an increase in spontaneous transmitter release (Fatt and Katz, 1952; Hubbard et al., 1968; Malgaroli and Tsien, 1992; Manabe et al., 1992).”
Background
Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus.
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“However, there is presently no consensus regarding the synaptic modification responsible for the enhanced transmission: studies suggest purely postsynaptic (Muller and Lynch, 1988; Kauer et al., 1988; Foster and McNaughton, 1991; Manabe et al., 1992), presynaptic (Dolphinetal.”
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“…the central nervous system, are the object of particular attention by the scientific community since their regulation appears to be crucial for controlling synaptic operation during learning and memory (Baudry and Lynch, 2001; Malinow and Malenka, 2002; Manabe et al., 1992; Massicotte, 2000).”
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Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP
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Presynaptic component of long-term potentiation visualized at individual hippocampal synapses.
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“Increased frequency but invariant mEPSC size during LTP mEPSCs have often been used to investigate LTP (Manabe et al. 1992; Kullman & Nicoll, 1992; Malgaroli et al. 1995).”
BackgroundMethodInfluential
Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression
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Paired pulse depression in cultured hippocampal neurons is due to a presynaptic mechanism independent of GABAB autoreceptor activation
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Background
Regulation of Long-Term Potentiation by H-Ras through NMDA Receptor Phosphorylation
Manabe, T., Aiba, A., Yamada, A., Ichise, T., Sakagami, H., Kondo, H., & Katsuki, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02504.2000 · Cited by 108
“Because many reports suggest that LTP is expressed, at least in part, by an increase in AMPA receptor sensitivity (Davies et al., 1989; Manabe et al., 1992; Manabe and Nicoll, 1994; Isaac et al., 1995; Liao et al., 1995), the larger magnitude of LTP could be explained by a downregulation of the AMPA receptor in naive…”
BackgroundSelf-citation
Nitric oxide and carbon monoxide as possible retrograde messengers in hgippocampal long‐term potentiation
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Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP
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“, 2001) and spontaneous miniature excitatory synaptic potentials (Malgaroli and Tsien, 1992; 1995; Manabe et al., 1992; Fernández-Ruiz et al., 2012) have been reported to be increased.”
Background

Authors: Manabe, T., Renner, P., & Nicoll, R. A.
Affiliations: University of California, San Francisco (US)
ORCID: Manabe, Toshiya
Nicoll, Roger A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1992-01
Volume: 355
Issue: 6355
Pages: 50-55
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/355050a0
OpenAlex: W1970096704
Cited by: 366
References: 35
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 3
FWCI: 22.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, miniature synaptic currents, CA1 pyramidal neurons, hippocampus, synaptic efficacy, excitatory synaptic transmission
MeSH terms: Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Pyramidal Tracts, Quinoxalines, Synapses, Tetrodotoxin, N-Methylaspartate, 6-Cyano-7-nitroquinoxaline-2,3-dione, In Vitro Techniques

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Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

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