Cited by 1,067Nerve injury and regenerationHereditary Neurological DisordersNeurogenesis and neuroplasticity mechanisms

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits

Ernfors, Patrik, Lee, Kuo-Fen, Jaenisch, Rudolf·1994·Nature

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Abstract

During vertebrate development, neuronal survival depends on target-derived neurotrophic factors. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions. Here we show that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion. The few remaining vestibular axons fail to contact the vestibular sensory epithelia, and terminate in the adjacent connective tissue. Survival of sympathetic, midbrain dopaminergic and motor neurons is not affected. These results indicate that BDNF is required for the survival and target innervation of particular neuronal populations.

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Self-citation
The Nerve Growth Factor 35 Years Later
Levi‐Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,109
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,503
Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section
Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H., & Barde, Y. (1992) · Nature · doi:10.1038/360757a0 · Cited by 706
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
Klein, R., Smeyne, R. J., Wurst, W., Long, L. K., Auerbach, B. A., Joyner, A. L., & Barbacid, M. (1993) · Cell · doi:10.1016/s0092-8674(05)80088-1 · Cited by 698
Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
Alderson, R. F., Alterman, A. L., Barde, Y., & Lindsay, R. M. (1990) · Neuron · doi:10.1016/0896-6273(90)90166-d · Cited by 685
Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death
Yan, Q., Elliott, J. L., & Snider, W. D. (1992) · Nature · doi:10.1038/360753a0 · Cited by 659
Neurotrophins promote motor neuron survival and are present in embryonic limb bud
Henderson, C. E., Camu, W., Mettling, C., Gouin, A., Poulsen, K., Karihaloo, M., Ruilamas, J., Evans, T., McMahon, S. B., Armanini, M. P., et al. (1993) · Nature · doi:10.1038/363266a0 · Cited by 608

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Lyon, M. F. & Searle, A. G. (eds) Genetic Variant and Strains of the Laboratory Mouse 2nd edn (Oxford Univ. Press, Oxford, 1989).

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Murphy, D. L., Uhl, G. R., Holmes, A., Ren‐Patterson, R. F., Hall, F. S., Sora, I., Detera‐Wadleigh, S. D., & Lesch, K. (2003) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2003.00049.x · Cited by 129
Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium
Roskams, A. J., Bethel, M., Hurt, K. J., & Ronnett, G. V. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01294.1996 · Cited by 129
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Activation of Phosphatidylinositol 3‐Kinase, but Not Extracellular‐Regulated Kinases, Is Necessary to Mediate Brain‐Derived Neurotrophic Factor‐Induced Motoneuron Survival
Dolcet, X., Egea, J., Soler, R. M., Martı́n-Zanca, D., & Comella, J. X. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730521.x · Cited by 127
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Fawcett, J. P., Aloyz, R. S., McLean, J. H., Pareek, S., Miller, F. D., McPherson, P. S., & Murphy, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8837 · Cited by 127
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Ward, N. L., & Lamanna, J. C. (2004) · Neurological Research · doi:10.1179/016164104x3798 · Cited by 122
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Briand, L. A., & Blendy, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.002 · Cited by 125
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Heuer, H., & Mason, C. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10604.2003 · Cited by 123
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Chan, J., Unger, T. J., BYRNES, J. J., & Rios, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.002 · Cited by 125
Brain‐derived neurotrophic factor mRNA is expressed in the developing taste bud‐bearing tongue papillae of rat
Nosrat, C. A., & Olson, L. (1995) · The Journal of comparative neurology · doi:10.1002/cne.903600413 · Cited by 123
Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts
Verdi, J. M., & Anderson, D. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90421-9 · Cited by 125
Neurotrophins regulate the function of cultured microglia
Nakajima, K., Kikuchi, Y., Ikoma, E., Honda, S., Ishikawa, M., Liu, Y., & Kohsaka, S. (1998) · Glia · doi:10.1002/(sici)1098-1136(199811)24:3 · Cited by 122
Brain-Derived Neurotrophic Factor Levels in Autism: A Systematic Review and Meta-Analysis
Saghazadeh, A., & Rezaei, N. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-3024-x · Cited by 125
Cell death in regenerating populations of neurons in BDNF mutant mice
Linnarsson, S., Willson, C. A., & Ernfors, P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00295-8 · Cited by 121
Self-citation
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Rohe, M., Synowitz, M., Glaß, R., Paul, S. M., Nykjær, A., & Willnow, T. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3960-09.2009 · Cited by 126
Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons
Minichiello, L., Piehl, F., Vázquez, E., Schimmang, T., Hökfelt, T. G. M., Represa, J., & Klein, R. (1995) · Development · doi:10.1242/dev.121.12.4067 · Cited by 120
THE ACTION OF NEUROTROPHINS IN THE DEVELOPMENT AND PLASTICITY OF THE VISUAL CORTEX
Cellerino, A., & Maffei, L. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00008-1 · Cited by 122
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Timmusk, T., Lendahl, U., Funakoshi, H., Arenas, E., Persson, H., & METSIS, M. L. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.1.185 · Cited by 125
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.
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Self-citation
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Self-citation
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Schimmang, T., Minichiello, L., Vázquez, E., José, I. S., Giráldez, F., Klein, R., & Represa, J. (1995) · Development · doi:10.1242/dev.121.10.3381 · Cited by 120
Genetic Modulation of BDNF Signaling Affects the Outcome of Axonal Competition In Vivo
Cao, L., Albers, A. D., Mukai, J., Blazeski, R., Lodovichi, C., Mason, C. A., & Gogos, J. A. (2007) · Current Biology · doi:10.1016/j.cub.2007.04.040 · Cited by 120
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Lambert, W. M., Xu, C., Neubert, T. A., Chao, M. V., Garabedian, M. J., & Jeanneteau, F. D. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00150-13 · Cited by 121
Brain-derived neurotrophic factor regulates the expression of AMPA receptor proteins in neocortical neurons
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Endothelin-B receptor is expressed by neural crest cells in the avian embryo.
Nataf, V., Lecoin, L., Eichmann, A., & Douarin, N. M. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9645 · Cited by 116
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Jiang, C. S., & Salton, S. R. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0103-8 · Cited by 117
Expression and function of TrkB variants in developing sensory neurons.
Ninkina, N. N., Adu, J., Fischer, A., Piñón, L. G. P., Buchman, V. L., & Davies, A. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01029.x · Cited by 112
Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder.
Ribasés, M., Hervás, A., Ramos-Quiroga, J., Bosch, R., Bielsa, A., Gastaminza, X., Fernández-Anguiano, M., Nogueira, M., Gómez-Barros, N., Valero, S., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.004 · Cited by 116
BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development
Agerman, K., Hjerling-Leffler, J., Blanchard, M.-P., Scarfone, E., Canlon, B., Nosrat, C. A., & Ernfors, P. (2003) · Development · doi:10.1242/dev.00378 · Cited by 114
Self-citation
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de la Torre-Ubieta, L., & Bonni, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.018 · Cited by 110
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Vega, J. A., García‐Suárez, O., Montano, J. A., Pardo, B., & Cobo, J. M. D. (2008) · Microscopy Research and Technique · doi:10.1002/jemt.20651 · Cited by 111
Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling
Piñón, L. G. P., Minichiello, L., Klein, R., & Davies, A. M. (1996) · Development · doi:10.1242/dev.122.10.3255 · Cited by 110
The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration
Pisani, A., Paciello, F., VECCHIO, V. D., Malesci, R., Corso, E. D., Cantone, E., & Fetoni, A. R. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13040652 · Cited by 127
Exogenous BDNF, NT-3 and NT-4 differentially regulate neurite outgrowth in cultured hippocampal neurons
Labelle, C., & Leclerc, N. M. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00069-9 · Cited by 110
BDNF and trkB mRNAs oscillate in rat brain during the light–dark cycle
Bova, R., Micheli, M. R., Qualadrucci, P., & Zucconi, G. G. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00092-8 · Cited by 110
Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice
Chourbaji, S., Brandwein, C., & Gass, P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.003 · Cited by 114
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Differential Dependency of Unmyelinated and Aδ Epidermal and Upper Dermal Innervation on Neurotrophins, Trk Receptors, and p75LNGFR
Rice, F. L., Albers, K. M., Davis, B. M., Silos‐Santiago, I., Wilkinson, G. A., LeMaster, A. M., Ernfors, P., Smeyne, R. J., Aldskogius, H., PHILLIPS, H. S., et al. (1998) · Developmental Biology · doi:10.1016/s0012-1606(98)80029-8 · Cited by 110
Self-citation
Expression of neurotrophins and Trk receptors in the avian retina
Hallböök, F., B�ckstr�m, A., Kullander, K., Ebendal, T., & Carri, N. G. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960122)364:4 · Cited by 110
Genetic and epigenetic control in neural crest development
Douarin, N. M. L., Dupin, É., & Ziller, C. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90135-p · Cited by 110
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Bernd, P. (2008) · Gene Expression · doi:10.3727/105221608786883799 · Cited by 107
Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy
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Jeanblanc, J., He, D., McGough, N. N. H., Logrip, M. L., Phamluong, K., Janak, P. H., & Dorit Ron, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3786-05.2006 · Cited by 108
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Self-citation
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Lindholm, J., Autio, H., Vesa, L., Antila, H., Lindemann, L., Hoener, M. C., Skolnick, P., Rantamäki, T., & Ċastrén, E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.015 · Cited by 102
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A Local Action of Neurotrophin-3 Prevents the Death of Proliferating Sensory Neuron Precursor Cells
ElShamy, W. M., & Ernfors, P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80119-1 · Cited by 102
Self-citation
Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities
Fan, G., Egles, C., Sun, Y. E., Minichiello, L., Renger, J. J., Klein, R., Liu, G., & Jaenisch, R. (2000) · Nature Neuroscience · doi:10.1038/73921 · Cited by 101
Self-citation
Identification of Maxillary Factor, a Maxillary Process–Derived Chemoattractant for Developing Trigeminal Sensory Axons
O'Connor, R., & Tessier‐Lavigne, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80830-2 · Cited by 103
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A null mutation in TGF-α leads to a reduction in midbrain dopaminergic neurons in the substantia nigra
Blum, M. (1998) · Nature Neuroscience · doi:10.1038/1584 · Cited by 101
Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice
Jang, S.-W., Liu, X., Chan, C. B., France, S. A., Sayeed, I., Tang, W., Lin, X., Xiao, G., Andero, R., Chang, Q., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011528 · Cited by 101
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Geiger, T. R., & Peeper, D. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0121 · Cited by 100
Neurotrophic factors in the therapy of diabetic neuropathy
Apfel, S. C. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00011-x · Cited by 100
Targeting the mouse genome: a compendium of knockouts (part I)
Brandon, E. P., Idzerda, R. L., & McKnight, G. S. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00127-8 · Cited by 100
Oestrogen regulates sympathetic neurite outgrowth by modulating brain derived neurotrophic factor synthesis and release by the rodent uterus
Krizsan‐Agbas, D., Pedchenko, T., Hasan, W., & Smith, P. G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03029.x · Cited by 99
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Botchkarev, V. A., Botchkareva, N. V., Welker, P., Metz, M., Lewin, G. R., Subramaniam, A., Bulfone‐Paus, S., Hagen, E., Braun, A. C., Lommatzsch, M., et al. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.395 · Cited by 100
Targeting the mouse genome: a compendium of knockouts (part II)
Brandon, E. P., Idzerda, R. L., & McKnight, G. S. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00152-7 · Cited by 97
Gender-Dependent Modulation of Brain Monoamines and Anxiety-like Behaviors in Mice with Genetic Serotonin Transporter and BDNF Deficiencies
Ren‐Patterson, R. F., Cochran, L. W., Holmes, A., Lesch, K., Lu, B., & Murphy, D. L. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9048-6 · Cited by 98
Neurotrophin-4 Deficient Mice Have a Loss of Vagal Intraganglionic Mechanoreceptors from the Small Intestine and a Disruption of Short-Term Satiety
Fox, E. A., Phillips, R. J., Baronowsky, E. A., Byerly, M. S., Jones, S., & Powley, T. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08602.2001 · Cited by 97
Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior
Vigers, A. J., Amin, D. S., Talley-Farnham, T., Gorski, J. A., Xu, B., & Jones, K. R. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.031 · Cited by 95
Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression
Gómez‐Casati, M. E., Murtie, J. C., Río, C., Stanković, K. M., Liberman, M. C., & Corfas, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008938107 · Cited by 97
Excitotoxicity in the Pathogenesis of Autism
Essa, M. M., Braidy, N., Vijayan, K. R., Subash, S., & Guillemin, G. J. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9354-3 · Cited by 97
TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
Davey, F. D., & Davies, A. M. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00371-5 · Cited by 98
Neurotrophin switching: where does it stand?
Davies, A. M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80128-6 · Cited by 97
Morphology of local axon collaterals of electrophysiologically characterised neurons in the rat medial septal/ diagonal band complex
Henderson, Z., Morris, N. P., Grimwood, P., Fiddler, G., Yang, H., & Appenteng, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010212)430:3 · Cited by 35
Retinotopy of the human retinal nerve fibre layer and optic nerve head
Fitzgibbon, T., & Taylor, S. F. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961111)375:2 · Cited by 104
Immunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain
Dugich‐Djordjevic, M. M., Peterson, C. M., Isono, F., Ohsawa, F., Widmer, H. R., Denton, T. L., Bennett, G. L., & Hefti, F. F. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00703.x · Cited by 97
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Giehl, K. M., Schütte, A., Mestres, P., & Yan, Q. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07351.1998 · Cited by 95
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Wu, Y. C., Hill, R., Gogos, A., & van den Buuse, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.024 · Cited by 95
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Li, J., Zhao, Y.-D., Zeng, J., Chen, X.-Y., Wang, R.-D., & Cheng, S. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.011 · Cited by 98
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Patterned expression of BDNF and NT-3 in the retina and anterior segment of the developing mammalian eye.
Bennett, J. L., Zeiler, S. R., & Jones, K. R. (1999) · PubMed · Cited by 94
Neurotrophins and the specification of neuronal phenotype
Lewin, G. R. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0035 · Cited by 95
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Hedges, V. L., Ebner, T. J., Meisel, R. L., & Mermelstein, P. G. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.005 · Cited by 94
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Authors: Ernfors, P., Lee, K.-F., & Jaenisch, R.
Affiliations: Whitehead Institute for Biomedical Research (US)
ORCID: Ernfors, Patrik
Lee, Kuo-Fen
Jaenisch, Rudolf
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1994-03
Volume: 368
Issue: 6467
Pages: 147-150
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/368147a0
OpenAlex: W2076894554
Cited by: 1,067
References: 22
Citations by year: 2026: 7 · 2025: 5 · 2024: 10 · 2023: 19 · 2022: 14 · 2021: 22 · 2020: 33 · 2019: 20 · 2018: 27 · 2017: 15 · 2016: 20 · 2015: 26 · 2014: 28 · 2013: 25 · 2012: 40
FWCI: 25.75
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain-derived neurotrophic factor, BDNF knockout mice, sensory neuron survival, motor neuron survival, dopaminergic neurons, sympathetic neurons, neurotrophins
MeSH terms: Animals, Animals, Newborn, Cell Line, Embryo, Mammalian, Embryonic and Fetal Development, Ganglia, Ear, Inner, Mice, Inbred BALB C, Mice, Mutant Strains, Movement Disorders, Mutation, Nerve Tissue Proteins, Nervous System, Neurons, Afferent, Stem Cells, Cell Death, Peripheral Nervous System, Brain-Derived Neurotrophic Factor, Mice

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits

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