Cited by 1,067Nerve injury and regenerationHereditary Neurological DisordersNeurogenesis and neuroplasticity mechanisms

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits

Ernfors, Patrik, Lee, Kuo-Fen, Jaenisch, Rudolf·1994·Nature

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Abstract

During vertebrate development, neuronal survival depends on target-derived neurotrophic factors. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, can prevent the death of particular peripheral sensory neurons in vitro, and of central motor neurons as well as dopaminergic and cholinergic neurons of the basal forebrain during development. It also prevents the death of motor neurons and midbrain dopaminergic neurons induced by lesions. Here we show that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion. The few remaining vestibular axons fail to contact the vestibular sensory epithelia, and terminate in the adjacent connective tissue. Survival of sympathetic, midbrain dopaminergic and motor neurons is not affected. These results indicate that BDNF is required for the survival and target innervation of particular neuronal populations.

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Authors: Ernfors, P., Lee, K.-F., & Jaenisch, R.
Affiliations: Whitehead Institute for Biomedical Research (US)
ORCID: Ernfors, Patrik
Lee, Kuo-Fen
Jaenisch, Rudolf
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1994-03
Volume: 368
Issue: 6467
Pages: 147-150
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/368147a0
OpenAlex: W2076894554
Cited by: 1,067
References: 22
Citations by year: 2026: 7 · 2025: 5 · 2024: 10 · 2023: 19 · 2022: 14 · 2021: 22 · 2020: 33 · 2019: 20 · 2018: 27 · 2017: 15 · 2016: 20 · 2015: 26 · 2014: 28 · 2013: 25 · 2012: 40
FWCI: 25.75
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: brain-derived neurotrophic factor, BDNF knockout mice, sensory neuron survival, motor neuron survival, dopaminergic neurons, sympathetic neurons, neurotrophins
MeSH terms: Animals, Animals, Newborn, Cell Line, Embryo, Mammalian, Embryonic and Fetal Development, Ganglia, Ear, Inner, Mice, Inbred BALB C, Mice, Mutant Strains, Movement Disorders, Mutation, Nerve Tissue Proteins, Nervous System, Neurons, Afferent, Stem Cells, Cell Death, Peripheral Nervous System, Brain-Derived Neurotrophic Factor, Mice

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits

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