Spl elements protect a CpG island from de novo methylation

CpG-rich islands and the function of DNA methylation

Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated

Höller, M., Westin, G., Jiricny, J., & Schaffner, W. (1988) · Genes & Development · doi:10.1101/gad.2.9.1127 · Cited by 305

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325

DNA methylation and its basic function

Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906

CpG islands and the regulation of transcription

Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187

Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078

DNA methylation: roles in mammalian development

Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267

Function and information content of DNA methylation

Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

Hark, A. T., Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., & Tilghman, S. M. (2000) · Nature · doi:10.1038/35013106 · Cited by 1,547

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

Saxonov, S., Berg, P., & Brutlag, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510310103 · Cited by 1,401

Epigenetics and the biological definition of gene×environment interactions

Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

Liu, X., Wang, C., Liu, W., Li, J., Li, C., Kou, X., Chen, J., Zhao, Y., Gao, H., Wang, H., et al. (2016) · Nature · doi:10.1038/nature19362 · Cited by 746

G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis

Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., & Bergman, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1353 · Cited by 651

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature · doi:10.1038/nature08924 · Cited by 625

DNA methylation dynamics in health and disease

Bergman, Y., & Cedar, H. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2518 · Cited by 592

Epigenetics and the environmental regulation of the genome and its function

Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565

DNA methylation signatures in development and aging of the human prefrontal cortex

Numata, S., Ye, T., Hyde, T. M., Guitart-Navarro, X., Tao, R., Wininger, M., Colantuoni, C., Weinberger, D. R., Kleinman, J. E., & Lipska, B. K. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.020 · Cited by 364

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions

Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

Catteau, A., Harris, W. H., Xu, C.-F., & Solomon, E. (1999) · Oncogene · doi:10.1038/sj.onc.1202509 · Cited by 354

DNA methylation represses transcription in vivo

Siegfried, Z., Eden, S., Mendelsohn, M., Feng, X., Tsuberi, B.-Z., & Cedar, H. (1999) · Nature Genetics · doi:10.1038/9727 · Cited by 354

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

Teh, A. L., Pan, H., Chen, L., Ong, M.-L., Dogra, S., Wong, J., MacIsaac, J. L., Mah, S. M., McEwen, L. M., Saw, S.-M., et al. (2014) · Genome Research · doi:10.1101/gr.171439.113 · Cited by 352

Sensitivity of transcription factors to DNA methylation

Héberlé, É., & Bardet, A. F. (2019) · Essays in Biochemistry · doi:10.1042/ebc20190033 · Cited by 347

Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.149 · Cited by 347

CTCF maintains differential methylation at the Igf2/H19 locus

Schoenherr, C. J., Levorse, J. M., & Tilghman, S. M. (2003) · Nature Genetics · doi:10.1038/ng1057 · Cited by 320

Role of DNA Methylation in Modulating Transcription Factor Occupancy

Maurano, M. T., Wang, H., John, S., Shafer, A., Canfield, T., Lee, K., & Stamatoyannopoulos, J. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.024 · Cited by 281

Reconfiguration of DNA methylation in aging

Zampieri, M., Ciccarone, F., Calabrese, R., Franceschi, C., Bürkle, A., & Caiafa, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.002 · Cited by 254

Initiation of DNA replication at CpG islands in mammalian chromosomes

Delgado, S., Gómez, M., Bird, A., & Antequera, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2426 · Cited by 242

Notes on the role of dynamic DNA methylation in mammalian development

Bestor, T. H., Edwards, J. R., & Boulard, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415301111 · Cited by 238

Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone–serotonin–NGFI-A signalling cascade

Hellstrom, I. C., Dhir, S. K., Diorio, J. C., & Meaney, M. J. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0223 · Cited by 171

Epigenetics and the Biological Basis of Gene × Environment Interactions

Bagot, R. C., & Meaney, M. J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.001 · Cited by 177

Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques

Kinnally, E. L., Capitanio, J. P., Leibel, R., Deng, L., LeDuc, C., Haghighi, F., & Mann, J. J. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00588.x · Cited by 155

Identification and characterization of the DNA binding domain of CpG-binding protein

Lee, J.-H., Voo, K. S., & Skalnik, D. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107179200 · Cited by 157

Tracing dynamic changes of DNA methylation at single cell resolution

Stelzer, Y., Shivalila, C. S., Soldner, F., Markoulaki, S., & Jaenisch, R. (2015) · Cell · doi:10.1016/j.cell.2015.08.046 · Cited by 141

The DMPK gene of severely affected myotonic dystrophy patients is hypermethylated proximal to the largely expanded CTG repeat

Steinbach, P., Gläser, D., Vogel, W., Wolf, M., & Schwemmle, S. (1998) · The American Journal of Human Genetics · doi:10.1086/301711 · Cited by 116

Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1α and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway

Jin, H.-O., An, S., Lee, H.-C., Woo, S.-H., Seo, S.-K., Choe, T.-B., Yoo, D.-H., Lee, S.-B., Um, H.-D., & Lee, S.-J. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2006.12.014 · Cited by 91

Environmental regulation of the neural epigenome

Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82

High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions

Krebs, A. R., Dessus-Babus, S., Burger, L., & Schübeler, D. (2014) · eLife · doi:10.7554/elife.04094 · Cited by 81

The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor

Weaver, I. C. G., Hellstrom, I. C., Brown, S. E., Andrews, S. D., Dymov, S., Diorio, J., Zhang, T.-Y., Szyf, M., & Meaney, M. J. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0513 · Cited by 67

Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters

Sarda, S., Das, A., Vinson, C., & Hannenhalli, S. (2017) · Genome Research · doi:10.1101/gr.212050.116 · Cited by 43

Epigenetic preparation of future gene induction kinetics

Xiong, J., & Zhu, B. (2025) · Annual Review of Genetics · doi:10.1146/annurev-genet-012825-093148 · Cited by 12