Cited by 626Nerve injury and regenerationNuclear Receptors and SignalingHereditary Neurological Disorders

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

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Ip, N Y, Ibáñez, C F, Nye, S H, McClain, J, Jones, P F, Gies, D R, Belluscio, L, Le Beau, M M +2 more·1992·Proceedings of the National Academy of Sciences

Abstract

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.

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Crossref · 10.1073/pnas.89.7.3060

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Authors
Ip, N. Y., Ibáñez, C. F., Nye, S. H., McClain, J., Jones, P. F., Gies, D. R., Belluscio, L., Le Beau, M. M., Espinosa, R., & Squinto, S. P.
Affiliations
  • Regeneron (United States) (US)
  • Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
Venue
Proceedings of the National Academy of Sciences
Published
1992-04
Volume
89
Issue
7
Pages
3060-3064
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2102353290
Cited by
626
References
32
Citations by year
2026: 3 · 2025: 1 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 15 · 2013: 12 · 2012: 5
FWCI
30.02
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
National Cancer Institute (P01CA040046, CA-40046)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords
neurotrophin-4, neurotrophins, nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, chromosome 19q13.3, pseudogenes, tissue distribution, evolutionary conservation, Xenopus, vipers
MeSH terms
Amino Acid Sequence, Animals, Chromosome Mapping, Chromosomes, Human, Pair 19, Cloning, Molecular, Genes, Humans, Molecular Sequence Data, Nerve Growth Factors, Proto-Oncogene Proteins, Pseudogenes, Receptors, Cell Surface, RNA, Messenger, Tissue Distribution, Gene Expression, Polymerase Chain Reaction, Sequence Alignment, 3T3 Cells, Receptor, trkA, Mice, Rats

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