Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Open accessAbstract
Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.
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- Authors
- Ip, N. Y., Ibáñez, C. F., Nye, S. H., McClain, J., Jones, P. F., Gies, D. R., Belluscio, L., Le Beau, M. M., Espinosa, R., & Squinto, S. P.
- Affiliations
- Regeneron (United States) (US)
- Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1992-04
- Volume
- 89
- Issue
- 7
- Pages
- 3060-3064
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC48803
- OpenAlex
- W2102353290
- Cited by
- 626
- References
- 32
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 15 · 2013: 12 · 2012: 5
- FWCI
- 30.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Cancer Institute (P01CA040046, CA-40046)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- neurotrophin-4, neurotrophins, nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, chromosome 19q13.3, pseudogenes, tissue distribution, evolutionary conservation, Xenopus, vipers
- MeSH terms
- Amino Acid Sequence, Animals, Chromosome Mapping, Chromosomes, Human, Pair 19, Cloning, Molecular, Genes, Humans, Molecular Sequence Data, Nerve Growth Factors, Proto-Oncogene Proteins, Pseudogenes, Receptors, Cell Surface, RNA, Messenger, Tissue Distribution, Gene Expression, Polymerase Chain Reaction, Sequence Alignment, 3T3 Cells, Receptor, trkA, Mice, Rats
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