Cited by 1,593Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

Williams, Graham V., Goldman-Rakic, Patricia S.·1995·Nature

DOI 10.1038/376572a0

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Abstract

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

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“…& Posner, 2005; Marrocco & Davidson, 1998); given that the thalamus and prefrontal cortex receive dense dopaminergic innervation (SánchezGonzález, García-Cabezas, Rico, & Cavada, 2005; Williams & Goldman-Rakic, 1995), we expected that alerting would be improved as a function of caffeine dose.”
Background
Molecular Influences on Working Memory Circuits in Dorsolateral Prefrontal Cortex
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Up-regulation of the D1 Dopamine Receptor–Interacting Protein, Calcyon, in Patients With Schizophrenia
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Self-citation
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Dopaminergic stimulation enhances confidence and accuracy in seeing rapidly presented words
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D2 dopamine receptors enable Δ9‐tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration
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Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex
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Dopamine vs Noradrenaline: Inverted-U Effects and ADHD Theories
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C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
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“... provided evidence of an inverted ‘U’ relationship between brain dopamine levels and working memory performance, with increasing dopamine receptor stimulation being associated with improved working memory performance up to an optimum, beyond which further dopamine receptor stimulation produces impairments in workin…”
Background
Prospective memory in Parkinson disease across laboratory and self-reported everyday performance.
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“…to background noise in the prefrontal cortex, thereby enhancing executive control skills; however, levels that are too low or too high may dampen or diffuse the signal, leading to impaired performance (Braver, Barch, & Cohen, 1999; for review, see Cools, 2006; Williams & Goldman-Rakic, 1995).”
Background
Burst generation in rat pyramidal neurones by regenerative potentials elicited in a restricted part of the basilar dendritic tree
Milojkovic, B. A., Radojicic, M. S., Goldman‐Rakic, P. S., & Antic, S. D. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.061416 · Cited by 75
“Given the normal background-firing rate of prefrontal cortical pyramidal neurones in vivo (Funahashi et al. 1989; Williams & Goldman-Rakic, 1995; Miller et al. 1996), synaptic integration in distal dendrites rarely occurs in the absence of somatic action potentials (APs).”
BackgroundSelf-citation
Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders
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Dopaminergic control of working memory and its relevance to schizophrenia: A circuit dynamics perspective
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Hyperdopaminergic Tone Erodes Prefrontal Long-Term Potential via a D 2 Receptor-Operated Protein Phosphatase Gate
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“…dopaminergic and glutamatergic inputs, are targets of the hippocampus (Carr and Sesack, 1996), and give rise to massive cortical and subcortical projections (Sesack et al., 1989), thus representing a core element of PFC executive circuits (Williams and Goldman-Rakic, 1995; Seamans and Yang, 2004).”
Background
Dopamine D 1 signaling organizes network dynamics underlying working memory
Roffman, J. L., Tanner, A. S., Eryilmaz, H., Rodriguez-Thompson, A., Silverstein, N. J., Ho, N. F., Nitenson, A. Z., Chonde, D. B., Greve, D. N., Abi‐Dargham, A., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501672 · Cited by 76
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“For example, D1Rs exhibit dose-dependent, inverted U-shape effects on the persistent activity of PFC neurons (14, 15) and on working memory (16).”
Background
Impaired executive function signals in motor brain regions in Parkinson's disease
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“2), so we cannot assume to have an ‘overdosing’ effect of dopamine in DLPFC (Cools, 2006; Williams and Goldman-Rakic, 1995).”
Background
Activation of Nigral and Pallidal Dopamine D1-Like Receptors Modulates Basal Ganglia Outflow in Monkeys
Kliem, M. A., Maidment, N. T., Ackerson, L. C., Chen, S., Smith, Y., & Wichmann, T. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00171.2007 · Cited by 75
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Genetic and epigenetic control of midbrain dopaminergic neuron development
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Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: A comparison with obsessive-compulsive disorder and healthy subjects
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Morin Attenuates Neurochemical Changes and Increased Oxidative/Nitrergic Stress in Brains of Mice Exposed to Ketamine: Prevention and Reversal of Schizophrenia-Like Symptoms
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Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile
Sun, H., Zhu, L., Yang, H., Qian, W., Guo, L., Zhou, S., Gao, B., Li, Z., Zhou, Y., Jiang, H., et al. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.12.016 · Cited by 74

Authors: Williams, G. V., & Goldman-Rakic, P. S.
Affiliations: Yale University (US)
ORCID: Williams, Graham V.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1995-08
Volume: 376
Issue: 6541
Pages: 572-575
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/376572a0
OpenAlex: W2084007108
Cited by: 1,593
References: 42
Citations by year: 2026: 17 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 27 · 2018: 37 · 2017: 33 · 2016: 48 · 2015: 63 · 2014: 45 · 2013: 78 · 2012: 74
FWCI: 16.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dopamine D1 receptor, working memory, prefrontal cortex, memory field, dopamine D1 receptor antagonist, synaptic modulation, excitatory synaptic input, iontophoresis, single-unit recording
MeSH terms: Animals, Haplorhini, Dose-Response Relationship, Drug, Iontophoresis, Memory, Neurons, Psychomotor Performance, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2

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Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

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