Cited by 1,593Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

Williams, Graham V., Goldman-Rakic, Patricia S.·1995·Nature

DOI 10.1038/376572a0

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Abstract

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

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Authors: Williams, G. V., & Goldman-Rakic, P. S.
Affiliations: Yale University (US)
ORCID: Williams, Graham V.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1995-08
Volume: 376
Issue: 6541
Pages: 572-575
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/376572a0
OpenAlex: W2084007108
Cited by: 1,593
References: 42
Citations by year: 2026: 17 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 27 · 2018: 37 · 2017: 33 · 2016: 48 · 2015: 63 · 2014: 45 · 2013: 78 · 2012: 74
FWCI: 16.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dopamine D1 receptor, working memory, prefrontal cortex, memory field, dopamine D1 receptor antagonist, synaptic modulation, excitatory synaptic input, iontophoresis, single-unit recording
MeSH terms: Animals, Haplorhini, Dose-Response Relationship, Drug, Iontophoresis, Memory, Neurons, Psychomotor Performance, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2

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Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

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