Cited by 1,593Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

Williams, Graham V., Goldman-Rakic, Patricia S.·1995·Nature

DOI 10.1038/376572a0

Open this paper in CoChat — free account

Abstract

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

Integrity signals

Registry

Crossref · 10.1038/376572a0

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Handbook of Physiology.
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
Self-citation
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 953
Dopamine receptors and the dopamine hypothesis of schizophrenia
Seeman, P. M. (1987) · Synapse · doi:10.1002/syn.890010203 · Cited by 880
Molecular cloning and expression of the gene for a human D1 dopamine receptor
Dearry, A., Gingrich, J. A., Falardeau, P., Fremeau, R. T., Bates, M. D., & Caron, M. G. (1990) · Nature · doi:10.1038/347072a0 · Cited by 674
l-Dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction
Lange, K. W., Robbins, T. W., MARSDEN, C. D., James-Galton, M., Owen, A. M., & Paul, G. M. (1992) · Psychopharmacology · doi:10.1007/bf02245167 · Cited by 624
Molecular Diversity of the Dopamine Receptors
Civelli, O., Bunzow, J. R., & Grandy, D. K. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.001433 · Cited by 623
Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates
Berger, B., Gaspar, P., & Verney, C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90179-x · Cited by 588

Flagged first, then by citations

Show all 42 references

Research works printed but not linked: 6

O'Scalaidhe, S. P. & Goldman-Rakic, P. S. Soc. Neurosci. Abstr. 19, 800 (1993).
Chipkin, R. E. et al. J. Pharmac. exp. Ther. 247, 1093–1102 (1988).
Fuster, J. M. in The Prefrontal Cortex 2nd edn 51–82 (Raven, New York, 1989).
Malmberg, A., Jackson, D. M., Eriksson, A. & Mohell, N. Molec. Pharmac. 43, 749–754 (1993).
Bergson, C. et al. Soc. Neurosci. Abstr. 20, 275 (1994).
Godbout, R., Mantz, J., Pirot, S., Glowinski, J. & Thierry, A. M. J. Pharmac. exp. Ther. 258, 728–738 (1991).

Sorted by citations

Items 301–400 of 1,002

Intact Reward Learning but Elevated Delay Discounting in Parkinson's Disease Patients With Impulsive-Compulsive Spectrum Behaviors
Housden, C. R., O’Sullivan, S. S., Joyce, E. M., Lees, A. J., & Roiser, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.84 · Cited by 183
“22 that this deficit is similarly related to disrupted dopamine transmission in PD (Floresco and Phillips 2001; Sawaguchi and Goldman-Rakic 1994; Williams and Goldman-Rakic 1995; Zahrt et al. 1997).”
Background
Prefrontal dopamine signaling and cognitive symptoms of Parkinson’s disease
Narayanan, N. S., Rodnitzky, R. L., & Uc, E. Y. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0004 · Cited by 181
Polymorphisms in dopamine receptors: what do they tell us?
Wong, A. H. C., Buckle, C. E., & Tol, H. H. M. V. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00815-3 · Cited by 176
The effect of short-term estrogen replacement therapy on cognition: A randomized, double-blind, cross-over trial in postmenopausal women*1
Polo‐Kantola, P. (1998) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00700-x · Cited by 176
Functional specialization within the dorsolateral prefrontal cortex: A review of anatomical and physiological studies of non-human primates
Hoshi, E. (2005) · Neuroscience Research · doi:10.1016/j.neures.2005.10.013 · Cited by 183
“…the catecholamine systems, because it has been shown that they play crucial roles in normal functioning of the prefrontal cortex (Arnsten and GoldmanRakic, 1985; Sawaguchi et al., 1990; Sawaguchi and GoldmanRakic, 1991, 1994; Williams and Goldman-Rakic, 1995; Sawaguchi, 1998; Wang et al., 2004).”
Hemispatial neglect.
Parton, A. D., Malhotra, P., & Husain, M. (2004) · PubMed Central · Cited by 175
Calcium signaling dysfunction in schizophrenia: a unifying approach
Lidow, M. S. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00203-0 · Cited by 174
Dual Signaling Regulated by Calcyon, a D1 Dopamine Receptor Interacting Protein
Lezcano, N. E., Mrzljak, L., Eubanks, S., Levenson, R. G., Goldman‐Rakic, P. S., & Bergson, C. M. (2000) · Science · doi:10.1126/science.287.5458.1660 · Cited by 175
Self-citation
Retracted
Influence of naturally occurring variations in maternal care on prepulse inhibition of acoustic startle and the medial prefrontal cortical dopamine response to stress in adult rats
Zhang, T. Y., Chrétien, P., Meaney, M. J., & Gratton, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3293-04.2005 · Cited by 174
“Dopamine (DA) plays a modulatory role here by optimizing the activity of mPFC neurons and the functions they subserve (Williams and Goldman-Rakic, 1995; Murphy et al., 1996).”
Background
The Effects of Dopamine D1Receptor Blockade in the Prelimbic–Infralimbic Areas on Behavioral Flexibility
Ragozzino, M. E. (2002) · Learning & Memory · doi:10.1101/lm.45802 · Cited by 174
Dopamine Enhances EPSCs in Layer II–III Pyramidal Neurons in Rat Prefrontal Cortex
Gonzalez-Islas, C. E., & Hablitz, J. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00867.2003 · Cited by 173
Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder
Downhill, J. E., Buchsbaum, M. S., Wei, T.-C., Spiegel-Cohen, J., Hazlett, E. A., Haznedar, M. M., Silverman, J. M., & Siever, L. J. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00123-1 · Cited by 174
Epistasis between catechol- O -methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function
Tan, H. Y., Chen, Q., Sust, S., Buckholtz, J. W., Meyers, J. D., Egan, M. F., Mattay, V. S., Meyer‐Lindenberg, A., Weinberger, D. R., & Callicott, J. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610125104 · Cited by 174
Association of the G1947A COMT (Val108/158Met) gene polymorphism with prefrontal P300 during information processing
Gallinat, J., Bajbouj, M., Sander, T., Schlattmann, P., Xu, K., Ferro, E., Goldman, D. A., & Winterer, G. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01973-x · Cited by 173
“Moreover, the observed association is plausible, given the important role of COMT in cortical dopamine removal and the impact of dopamine on neuronal “noise” suppression during information processing (Robledo et al 1993; Sawaguchi 1987; Sawaguchi et al 1988; Williams and Goldman-Rakic 1995).”
A top-down perspective on dopamine, motivation and memory
Phillips, A. G., Vacca, G., & Ahn, S. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.10.014 · Cited by 169
Selective modulation of excitatory and inhibitory microcircuits by dopamine
Gao, W.-J., & Goldman-Rakic, P. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262796399 · Cited by 170
Dopamine overdose hypothesis: Evidence and clinical implications
Vaillancourt, D. E., Schonfeld, D., Kwak, Y., Bohnen, N. I., & Seidler, R. D. (2013) · Movement Disorders · doi:10.1002/mds.25687 · Cited by 171
Persistence and brain circuitry
Gusnard, D. A., Ollinger, J. M., Shulman, G. L., Cloninger, C. R., Price, J. L., Essen, D. C. V., & Raichle, M. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0538050100 · Cited by 177
Dopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex
Henze, D. A., González‐Burgos, G., Urban, N. N., Lewis, D. A., & Barrionuevo, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.2799 · Cited by 174
The role of neuromodulators in selective attention
Noudoost, B., & Moore, T. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.006 · Cited by 161
Insights into the Role of Dopamine Receptor Systems in Learning and Memory
El-Ghundi, M., O’Dowd, B. F., & George, S. R. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.1.37 · Cited by 174
Local and Distributed Effects of Apomorphine on Fronto-Temporal Function in Acute Unmedicated Schizophrenia
Fletcher, P. C., Frith, C., Grasby, P. M., Friston, K. J., & Dolan, R. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-07055.1996 · Cited by 169
The Cognitive Neuroscience of Working Memory: Relevance to CNTRICS and Schizophrenia
Barch, D. M., & Smith, E. E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.003 · Cited by 175
Behavioral characterization of dopamine D-sub-5 receptor null mutant mice.
Holmes, A., Hollon, T. R., Gleason, T., Liu, Z., Dreiling, J. L., Sibley, D. R., & Crawley, J. N. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1129 · Cited by 168
The Synaptic Hypothesis of Schizophrenia
Frankle, W. G., Lerma, J., & Laruelle, M. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00423-9 · Cited by 172
Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers
Barch, D. M., & Carter, C. S. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.12.019 · Cited by 222
“In addition, administration of low dose DA agonists can improve working memory in monkeys (Williams and Goldman-Rakic, 1995), especially those with impaired performance (Arnsten et al.”
Background
The role of catecholamines in seizure susceptibility: new results using genetically engineered mice
Weinshenker, D., & Szot, P. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00218-8 · Cited by 165
Dopamine Modulates Persistent Synaptic Activity and Enhances the Signal-to-Noise Ratio in the Prefrontal Cortex
Kroener, S., Chandler, L. J., Phillips, P. E. M., & Seamans, J. K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006507 · Cited by 165
“a ‘‘signal’’) in working memory [1,3–5].”
Background
The what, where and how of delay activity
Sreenivasan, K. K., & D’Esposito, M. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0176-7 · Cited by 168
CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology
Noble, F., & Roques, B. P. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00090-2 · Cited by 164
Dopamine receptor-interacting proteins: the Ca2+ connection in dopamine signaling
Bergson, C. M., Levenson, R. G., Goldman‐Rakic, P. S., & Lidow, M. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00232-3 · Cited by 164
Self-citation
Enriched Encoding: Reward Motivation Organizes Cortical Networks for Hippocampal Detection of Unexpected Events
Murty, V. P., & Adcock, R. A. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht063 · Cited by 167
5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons
Llado-Pelfort, L., Santana, N., Ghisi, V., Artigas, F., & Celada, P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr220 · Cited by 156
“An increase of pyramidal neuron activity in mPFC may balance monoamine neurotransmission in this area and facilitate the activity of mPFC in tasks, such as working memory, which require persistent activity of pyramidal neurons (Williams and Goldman-Rakic 1995; Fuster 2008; Robbins and Arnsten 2009).”
Frequency and Timing of Severe Hypoglycemia Affects Spatial Memory in Children With Type 1 Diabetes
Hershey, T. G., Perantie, D. C., Warren, S. L., Zimmerman, E. C., Sadler, M., & White, N. H. (2005) · Diabetes Care · doi:10.2337/diacare.28.10.2372 · Cited by 157
The ability of the mesocortical dopamine system to operate in distinct temporal modes
Lapish, C. C., Kroener, S., Durstewitz, D., Lavı́n, A., & Seamans, J. K. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0527-8 · Cited by 153
“…the spatial tuning of working memory fields in behaving primates is abolished by a GABAergic antagonist and enhanced by low doses of a D1 receptor antagonist presumably by removing the D1-mediated modulation of interneuron activity (Williams and Goldman-Rakic 1995; Goldman-Rakic et al. 2000).”
Background
11. The effects of positive affect and arousal on working memory and executive attention
Ashby, F. G., Valentin, V. V., & Turken, A. U. (2002) · Advances in consciousness research · doi:10.1075/aicr.44.11ash · Cited by 160
Dopamine D4Receptors Modulate GABAergic Signaling in Pyramidal Neurons of Prefrontal Cortex
Wang, X., Zhong, P., & Yan, Z. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09185.2002 · Cited by 155
Adverse Effects of Risperidone on Spatial Working Memory in First-Episode Schizophrenia
Reilly, J. L., Harris, M. S. H., Keshavan, M. S., & Sweeney, J. A. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1189 · Cited by 155
“Neurophysiologic studies have established that there is an optimal, but narrow, range of D1 receptor activity of prefrontal neurons during the delay period when information has to be remembered on the ODR task, with either too much or too little receptor stimulation associated with working memory impairment.(24) This…”
In Vivo Excitation of GABA Interneurons in the Medial Prefrontal Cortex through 5-HT3 Receptors
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh097 · Cited by 153
“In particular, the mesocortical dopaminergic system is involved in working memory and cognition through a complex control of the activity of pyramidal neurons (Willliams and Goldman-Rakic, 1995; Goldman-Rakic, 1996; O’ Donnell, 2003; Wang et al., 2003).”
Background
D 2 -Like Dopamine Autoreceptor Activation Reduces Quantal Size in PC12 Cells
Pothos, E. N., Przedborski, S., Davila, V., Schmitz, Y., & Sulzer, D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05575.1998 · Cited by 151
Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia.
Gottesman, I. I., & Erlenmeyer‐Kimling, L. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00245-6 · Cited by 159
Spatial, but not object, delayed response is impaired in early Parkinson's disease.
Postle, B. R., Jonides, J., Smith, E. E., Corkin, S., & Growdon, J. H. (1997) · Neuropsychology · doi:10.1037/0894-4105.11.2.171 · Cited by 154
Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00292.x · Cited by 155
Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys
Lee, B., Groman, S., London, E. D., & Jentsch, J. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301337 · Cited by 148
“However, it is simply unknown whether the D1like receptors play a role in reversal learning, although the D1-like receptors are critically involved in other cognitive functions, such as working memory (Sawaguchi and Goldman-Rakic, 1991; Williams and Goldman-Rakic, 1995) and visual attention (Granon et al, 2000).”
Background
Dose-Dependent Effects of the Dopamine D1 Receptor Agonists A77636 or SKF81297 On Spatial Working Memory in Aged Monkeys
Cai, J. X., & Arnsten, A. F. T. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36983-6 · Cited by 285
Dopamine Dysfunction in Borderline Personality Disorder: A Hypothesis
Friedel, R. O. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300424 · Cited by 152
“DA modulates cognitive processes in the PFC by gating glutamate activity at NMDA receptors (Williams and Goldman-Rakic, 1995).”
Background
Dextroamphetamine Enhances “Neural Network-Specific” Physiological Signals: A Positron-Emission Tomography rCBF Study
Mattay, V. S., Berman, K. F., Ostrem, J. L., Esposito, G., Van Horn, J. D., Bigelow, L. B., & Weinberger, D. R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04816.1996 · Cited by 151
Electrophysiological Properties of Pyramidal Neurons in the Rat Prefrontal Cortex: An In Vivo Intracellular Recording Study
Dégenètais, E. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.1.1 · Cited by 160
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010512 · Cited by 149
“(Williams and Goldman-Rakic, 1995; Vijayraghavan et al., 2007; Arnsten et al., 2009).”
Neural Systems Underlying Arousal and Attention: Implications for Drug Abusea
Robbins, T. W., Granon, S., Muir, J. L., Durantou, F., Harrison, A. A., & Everitt, B. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09740.x · Cited by 152
Chemistry of the Adaptive Mind: Lessons from Dopamine
Cools, R. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.035 · Cited by 150
Measurement of Striatal and Extrastriatal Dopamine D 1 Receptor Binding Potential With [ 11 C]NNC 112 in Humans: Validation and Reproducibility
Abi‐Dargham, A., Martínez, D., Mawlawi, O. R., Simpson, N. R., Hwang, D., Slifstein, M., Anjilvel, S., Pidcock, J., Guo, N., Lombardo, I., et al. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200002000-00003 · Cited by 143
Enhancement of Working Memory in Aged Monkeys by a Sensitizing Regimen of Dopamine D 1 Receptor Stimulation
Castner, S. A., & Goldman, P. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3987-03.2004 · Cited by 146
“A restricted range for D1 receptor stimulation has also been found for the expression of spatially tuned delay activity or memory fields, in prefrontal neurons—the physiological underpinning of spatial working memory (Sawaguchi and GoldmanRakic, 1991; Williams and Goldman-Rakic, 1995).”
Background
The Role of Prefrontal Dopamine D1 Receptors in the Neural Mechanisms of Associative Learning
Puig, M. V., & Miller, E. K. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.018 · Cited by 155
“stimulation strengthen and sculpt selectivity to optimize PFC function (Williams and Goldman-Rakic, 1995; Zahrt et al., 1997; Seamans et al., 1998; Granon et al., 2000; Chudasama and Robbins, 2004; Vijayraghavan et al., 2007).”
Influential
5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex
Lacroix, L. P., Dawson, L. A., Hagan, J. J., & Heidbreder, C. A. (2003) · Synapse · doi:10.1002/syn.10288 · Cited by 150
D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour
Boehmler, W., Carr, T., Thisse, C., Thisse, B., Canfield, V. A., & Levenson, R. G. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00243.x · Cited by 146
“Among the D2-like family of DRs, the D4 DR (D4R) has been of particular interest because it is densely expressed in the frontal cortex (Mrzljak et al. 1996), a brain region where dopamine signalling may modulate working memory and the establishment of memory fields (Williams & Goldman-Rakic 1995).”
Background
Catechol-O-Methyltransferase Val158Met Modulation of Prefrontal–Parietal–Striatal Brain Systems during Arithmetic and Temporal Transformations in Working Memory
Tan, H.-Y., Chen, Q., Goldberg, T. E., Mattay, V. S., Meyer-Lindenberg, A., Weinberger, D. R., & Callicott, J. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4041-07.2007 · Cited by 144
“These results build on neural recordings in which dopaminergic tuning mechanisms were observed to play key roles in encoding and actively maintaining information signal, and in protecting or stabilizing them against neural noise (Williams and Goldman-Rakic, 1995; Seamans and Yang, 2004; Vijayraghavan et al., 2007).”
BackgroundResultInfluential
New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons
Chandler, D. J., Waterhouse, B. D., & Gao, W. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00053 · Cited by 143
From arousal to cognition: the integrative position of the prefrontal cortex
Robbins, T. W. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26030-5 · Cited by 147
COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase Inhibition
Farrell, S., Tunbridge, E. M., Braeutigam, S., & Harrison, P. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.023 · Cited by 150
Rule Learning and Reward Contingency Are Associated with Dissociable Patterns of Dopamine Activation in the Rat Prefrontal Cortex, Nucleus Accumbens, and Dorsal Striatum
Stefani, M. R., & Moghaddam, B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1656-06.2006 · Cited by 149
“Other roles ascribed dopamine include the support or modulation of reward salience (Berridge and Robinson, 1998), goal-directed activity (Salamone and Correa, 2002), working memory (Williams and Goldman-Rakic, 1995), and memory consolidation (Wise, 2004).”
Background
Repeated Daily Cocaine Alters Subsequent Cocaine-induced Increase of Extracellular Dopamine in the Medial Prefrontal Cortex
Sorg, B. A., Davidson, D. L., Kalivas, P. W., & Prasad, B. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36617-0 · Cited by 144
Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null,Drd1a−/−Mice and in Hippocampal siRNA Silenced Drd1a Mice
Ortiz, O., Delgado-García, J. M., Espadas, I., Bahí, A., Trullas, R., Dreyer, J.-L., Gruart, A., & Moratalla, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2655-10.2010 · Cited by 143
“Conversely, dopaminergic dysfunction significantly alters spatial learning and short- and longterm memory in rodents and in nonhuman primates (Whishaw and Dunnett, 1985; Williams and Goldman-Rakic, 1995).”
Background
Individual capacity differences predict working memory performance and prefrontal activity following dopamine receptor stimulation
GIBBS, S. E. B., & D'ESPOSITO, M. (2005) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.5.2.212 · Cited by 145
“…that examined the effects of various dosages of dopaminergic agonist and antagonist treatments (Arnsten & Goldman-Rakic, 1998; Sawaguchi & GoldmanRakic, 1994; Williams & Goldman-Rakic, 1995; Zahrt et al., 1997), each individual has an optimal dopamine concentration for optimal cognitive processing.”
Background
Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia
Nicodemus, K. K., Kolachana, B. S., Vakkalanka, R., Straub, R. E., Giegling, I., Egan, M. F., Rujescu, D., & Weinberger, D. R. (2006) · Human Genetics · doi:10.1007/s00439-006-0257-3 · Cited by 145
Dopamine and psychosis: Theory, pathomechanisms and intermediate phenotypes
Tost, H., Alam, T., & Meyer-Lindenberg, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.005 · Cited by 160
“This suggests that the COMT Val allele might increase risk for schizophrenia by enhancing dopamine catabolism, which in turn impairs the functional efficacy of the PFC (Egan et al., 2001, Chen et al., 2004).”
BackgroundResultInfluential
Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia
Bertolino, A., Fazio, L., Caforio, G., Blasi, G., Rampino, A., Romano, R., Giorgio, A. D., Taurisano, P., Papp, A. C., Pinsonneault, J. K., et al. (2008) · Brain · doi:10.1093/brain/awn248 · Cited by 142
“| Brain 2009: 132; 417–425 (Arnsten et al., 1995; Williams and Goldman-Rakic, 1995; Wang et al., 2004).”
Background
Neurochemical brain imaging investigations of schizophrenia
Soares, J. C., & Innis, R. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00015-3 · Cited by 142
Plasticity at hippocampal to prefrontal cortex synapses is impaired by loss of dopamine and stress: Importance for psychiatric diseases
Jay, T. M., Rocher, C., Hotte, M., Naudon, L., Gurden, H., & Spedding, M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033225 · Cited by 141
Dopaminergic signaling in dendritic spines
Yao, W., Spealman, R. D., & Zhang, J. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.01.018 · Cited by 142
Dopamine D4Receptor-Deficient Mice Display Cortical Hyperexcitability
Rubinstein, M., Cepeda, C., Hurst, R. S., Flores‐Hernández, J., Ariano, M. A., Falzone, T. L., Kozell, L. B., Meshul, C. K., Bunzow, J. R., Low, M. J., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03756.2001 · Cited by 138
Pharmacologic strategies for augmenting cognitive performance in schizophrenia
Friedman, J. I., Temporini, H. D., & Davis, K. L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00287-x · Cited by 139
An in vivo assay of synaptic function mediating human cognition
Moran, R. J., Symmonds, M., Stephan, K. E., Friston, K. J., & Dolan, R. J. (2011) · Current Biology · doi:10.1016/j.cub.2011.06.053 · Cited by 137
Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity
Schweitzer, J. B., Lee, D. O., Hanford, R. B., Zink, C. F., Ely, T. D., Tagamets, M. A., Hoffman, J. M., Grafton, S. T., & Kilts, C. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.011 · Cited by 135
“…i e b i f n F o d c w t t u i a a t s T b t h w cting through D1 receptors, appears to inhibit local excitatory onnections among layer V pyramidal cells in the PFC (Gao et al 001; Williams and Goldman-Rakic 1995) during WM tasks. hese actions likely account for the rCBF reductions we have bserved.”
Background
On the Origin of Cortical Dopamine: Is it a Co-Transmitter in Noradrenergic Neurons?
Devoto, P., & Flore, G. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359559 · Cited by 137
“These catecholamines exert a biphasic effect on cognitive functioning, determining an inverted-U shaped dose-curve, normal cognitive operation occurring only within a limited range of dopaminergic and noradrenergic activity [7, 8, 47, 73, 82, 125].”
Background
TheGinkgo bilobaextract EGb 761®and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex
Yoshitake, T., Yoshitake, S., & Kehr, J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00580.x · Cited by 139
Parsing cognition in schizophrenia using saccadic eye movements: a selective overview
Broerse, A., Crawford, T. J., & den Boer, J. A. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00155-x · Cited by 136
Catechol O-Methyltransferase Val158Met Polymorphism is Associated with Cognitive Performance in Nondemented Adults
de Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929054475136 · Cited by 141
Dopamine Modulation of Membrane and Synaptic Properties of Interneurons in Rat Cerebral Cortex
Zhou, F.-M., & Hablitz, J. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.3.967 · Cited by 136
Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioningPreprint
Kalmbach, B. E., Ohyama, T., Kreider, J. C., Riusech, F., & Mauk, M. D. (2009) · Learning & Memory · doi:10.1101/lm.1178309 · Cited by 142
α7 and non‐α7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex
Livingstone, P. D., Srinivasan, J., Kew, J. N. C., Dawson, L. A., Gotti, C., Moretti, M., Shoaib, M., & Wonnacott, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06613.x · Cited by 133
“Dopamine is a prominent modulator of PFC executive functions, including working memory and attention (Williams & Goldman-Rakic, 1995; Schultz, 2002; Floresco & Magyar, 2006).”
Background
Preweaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels
Kern, C. H., Stanwood, G. D., & Smith, D. R. (2009) · Synapse · doi:10.1002/syn.20736 · Cited by 136
Spatial working memory alters the efficacy of input to visual cortex
Merrikhi, Y., Clark, K., Albarran, E., Parsa, M., Zirnsak, M., Moore, T., & Noudoost, B. (2017) · Nature Communications · doi:10.1038/ncomms15041 · Cited by 134
Tuning the engine of cognition: A focus on NMDA/D1 receptor interactions in prefrontal cortex
Castner, S. A., & Williams, G. V. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2006.11.002 · Cited by 134
Self-citation
Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism
Giakoumaki, S. G., Roussos, P., & Bitsios, P. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.82 · Cited by 136
Serotonin/dopamine interaction in memory formation
González‐Burgos, I., & Feria‐Velasco, A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00928-x · Cited by 138
Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes
Holmes, A., Lachowicz, J. E., & Sibley, D. R. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.034 · Cited by 133
Mesocortical dopamine and HPA axis regulation: Role of laterality and early environment
Sullivan, R. M., & Dufresne, M. M. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.100 · Cited by 131
“…window of prefrontal DAergic function in numerous forms of learning and working memory, not only in primates (Sawaguchi and Goldman-Rakic, 1991; Williams and Goldman-Rakic, 1995), but also in various attentional and learning processes in rodents, including the extinction of conditioned fear…”
Background
The Neuromodulatory System: A Framework for Survival and Adaptive Behavior in a Challenging World
Krichmar, J. L. (2008) · Adaptive Behavior · doi:10.1177/1059712308095775 · Cited by 132
FROST: A Distributed Neurocomputational Model of Working Memory Maintenance
Ashby, F. G., Ell, S. W., Valentin, V. V., & Casale, M. B. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/089892905774589271 · Cited by 132
“As Figure 1 shows, several single-unit recording studies have reported pFC cells whose firing increases at the beginning of the delay rather than during stimulus presentation ( Williams & Goldman-Rakic, 1995; Fuster, 1973; Fuster & Alexander, 1971).”
Background
Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex
Santana, N., & Artigas, F. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00087 · Cited by 135
“This expression pattern may be relevant to understand the inverted U relationship between D1-R activation and working memory performance (Williams and Goldman-Rakic, 1995).”
Background
Neural activity in prefrontal cortex during copying geometrical shapes
Averbeck, B. B., Crowe, D. A., Chafee, M. V., & Georgopoulos, A. P. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1417-5 · Cited by 133
Theoretical neurobiology and schizophrenia
Friston, K. J. (1996) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011573 · Cited by 129
The roles of sequencing and verbal working memory in sentence comprehension deficits in Parkinson’s disease
Hochstadt, J., Nakano, H., LIEBERMAN, P. H., & Friedman, J. H. (2005) · Brain and Language · doi:10.1016/j.bandl.2005.10.011 · Cited by 134
Perinatal Distress Leads to Lateralized Medial Prefrontal Cortical Dopamine Hypofunction in Adult Rats
Brake, W. G., Sullivan, R. M., & Gratton, A. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05538.2000 · Cited by 131
The dopamine D4 receptor: biochemical and signalling properties
Rondou, P., Haegeman, G., & Craenenbroeck, K. V. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0293-y · Cited by 146
Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
Weickert, T. W., Goldberg, T. E., Mishara, A. L., Apud, J. A., Kolachana, B. S., Egan, M. F., & Weinberger, D. R. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.012 · Cited by 130
Neurofeedback-mediated self-regulation of the dopaminergic midbrain
Sulzer, J. S., Sitaram, R., Blefari, M. L., Kollias, S., Birbaumer, N., Stephan, K. E., Luft, A. R., & Gassert, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.115 · Cited by 129
“…(York, 1970), nucleus accumbens (Salamone and Correa, 2002), hippocampus (Rossato et al., 2009), amygdala (Wilson et al., 1994), subthalamic nucleus (Limousin et al., 1998) and prefrontal cortex (Williams and Goldman-Rakic, 1995) — all brain regions with presumed involvement in reward processing.”
Background
Postnatal alterations in dopaminergic markers in the human prefrontal cortex
Weickert, C. S., Webster, M. J., Gondipalli, P., Rothmond, D., Fatula, R. J., Herman, M. M., Kleinman, J. E., & Akil, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.009 · Cited by 126
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity
Sidiropoulou, K., Lu, F.-M., Fowler, M. A., Xiao, R., Phillips, C. W., Ozkan, E. D., Zhu, M. X., White, F. J., & Cooper, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2245 · Cited by 131

Authors: Williams, G. V., & Goldman-Rakic, P. S.
Affiliations: Yale University (US)
ORCID: Williams, Graham V.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1995-08
Volume: 376
Issue: 6541
Pages: 572-575
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/376572a0
OpenAlex: W2084007108
Cited by: 1,593
References: 42
Citations by year: 2026: 17 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 27 · 2018: 37 · 2017: 33 · 2016: 48 · 2015: 63 · 2014: 45 · 2013: 78 · 2012: 74
FWCI: 16.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dopamine D1 receptor, working memory, prefrontal cortex, memory field, dopamine D1 receptor antagonist, synaptic modulation, excitatory synaptic input, iontophoresis, single-unit recording
MeSH terms: Animals, Haplorhini, Dose-Response Relationship, Drug, Iontophoresis, Memory, Neurons, Psychomotor Performance, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks