The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Abstract
Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.
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“evidence from non‐human primates (Sawaguchi & Goldman‐Rakic, 1991, 1994; Williams & Goldmanrakic, 1995) and in healthy humans (Fischer et al., 2010) showed that dopamine depletion or antagonism impairs visuospatial WM.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Williams & Goldmanrakic, 1995
In the citing paper
“Third, dopamine exerts a significant influence over prefrontal cortical functions such as working memory (Williams and Goldman-Rakic, 1995), in a manner that depends on initial levels or efficacy of this neuromodulator (Cools and D’Esposito, 2011).”
From Goals and Habits in the Brain (2013) · cites this paper as Williams and Goldman-Rakic, 1995
In the citing paper
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [205]
In the citing paper
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [205]
In the citing paper
“It is also consistent with a growing literature documenting baseline performance-dependent effects of stimulants and related drugs, which have been explained by a hypothesized inverted U-shaped function, whereby optimal catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired performance (Robbins and Sahakian, 1979; N”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Williams and Goldman-Rakic, 1995
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Items 201–300 of 1,002
Granado, N., Ortiz, Ó., Suárez, L. M., Martín, E. D., Ceña, V., Solís, J. M., & Moratalla, R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm026 · Cited by 257
Levodopa: Faster and better word learning in normal humans
Knecht, S., Breitenstein, C., Bushuven, S., Wailke, S., Kamping, S., Flöel, A., Zwitserlood, P., & Ringelstein, E. B. (2004) · Annals of Neurology · doi:10.1002/ana.20125 · Cited by 252
“Other than its involvement in the internal reward system, dopamine regulates the excitability of the prefrontal cortical circuitry underlying working memory.(4) Finally, dopamine receptor agonists have been shown to enhance long-term potentiation at hippocampal-prefrontal synapses,(42) which may promote memory consoli…”
BackgroundDissociation in human prefrontal cortex of affective influences on working memory-related activity
Perlstein, W. M., Elbert, T. R., & Stenger, V. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241650598 · Cited by 263
Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia
Winterer, G., Coppola, R., Goldberg, T. E., Egan, M. F., Jones, D. W., Sanchez, C. E., & Weinberger, D. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.3.490 · Cited by 246
The dopaminergic midbrain encodes the expected certainty about desired outcomes
Schwartenbeck, P., FitzGerald, T. H. B., Mathys, C., Dolan, R., & Friston, K. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu159 · Cited by 219
Potentiation of NMDA receptor currents by dopamine D 1 receptors in prefrontal cortex
Chen, G., Greengard, P., & Yan, Z. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308618100 · Cited by 245
Gene–gene interaction associated with neural reward sensitivity
Yacubian, J., Sommer, T., Schroeder, K., Gläscher, J., Kalisch, R., Leuenberger, B., Braus, D. F., & Büchel, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702029104 · Cited by 241
Dynamics of a recurrent network of spiking neurons before and following learning
Amit, D. J., & Brunel, N. (1997) · Network Computation in Neural Systems · doi:10.1088/0954-898x_8_4_003 · Cited by 238
Functional imaging of the human dopaminergic midbrain
Düzel, E., Bunzeck, N., Guitart-Masip, M., Wittmann, B., Schott, B. H., & Tobler, P. N. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.005 · Cited by 216
Positive Affect Versus Reward: Emotional and Motivational Influences on Cognitive Control
Chiew, K. S., & Braver, T. S. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00279 · Cited by 268
“In contrast, DA antagonists reduce both active maintenance related PFC activity, and also cause behavioral impairments in working memory and cognitive control tasks (Sawaguchi et al., 1990; Sawaguchi and GoldmanRakic, 1994; Williams and Goldman-Rakic, 1995).”
BackgroundFusar-Poli, P., Howes, O. D., Allen, P., Broome, M., Valli, I., Asselin, M.-C., Grasby, P. M., & McGuire, P. K. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.77 · Cited by 234
“According to this model, there is a dopamine activity level that is optimal for efficient working memory function, corresponding to the peak of the inverted U curve.(19,62,63) The opposite direction of the correlations between Ki and prefrontal activation in the ARMS and control groups can be interpreted as reflecting…”
BackgroundDreisbach, G. (2005) · Brain and Cognition · doi:10.1016/j.bandc.2005.08.003 · Cited by 258
“On Wrst glance this assumption might seem to be at odds with Wndings from animal studies, showing that DA improves performance in simple WM tasks (Arnsten, Cai, Murphy, & Goldman-Rakic, 1994; Brozoski, Brown, Rosvold, & Goldman, 1979; Williams & Goldman-Rakic, 1995 ).”
ResultSustained Activity Encoding Working Memories: Not Fully Distributed
Leavitt, M. L., Mendoza-Halliday, D., & Martínez-Trujillo, J. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.004 · Cited by 238
“Studies in the monkey PFC have shown that sustained activity is sensitive to manipulations of dopaminergic systems [87].”
BackgroundIncrease of Extracellular Dopamine in Primate Prefrontal Cortex During a Working Memory Task
Watanabe, M., Kodama, T., & Hikosaka, K. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.5.2795 · Cited by 237
Dopamine D5 receptors of rat and human brain
Khan, Z. U., Gutiérrez, A., Martı́n, R., Peñafiel, A., Rivera, A., & de la Calle, A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00274-8 · Cited by 236
Differential regulation of fronto-executive function by the monoamines and acetylcholine
Robbins, T., & Roberts, A. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm066 · Cited by 279
Santana, N., Mengod, G., & Artigas, F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn134 · Cited by 231
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232
“…is critically involved in working memory and cognition through a complex control of the activity of pyramidal neurons (Glowinski et al., 1984; Williams and Goldman-Rakic, 1995; Goldman-Rakic, 1996; Yang and Seamans, 1996; Robbins, 2000; Tzschentke, 2001; O’Donnell, 2003; Wang et al., 2003).”
BackgroundInhibitory Plasticity: Balance, Control, and Codependence
Hennequin, G., Agnes, E. J., & Vogels, T. P. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031005 · Cited by 236
“Inspired by experimental research (Figure 5g) (Goldman-Rakic 1995, Williams & GoldmanRakic 1995), modelers included embedded cell assemblies in spiking neural networks that can maintain high firing rates in a self-sustained fashion even after the initial stimulus ends (Brunel & Wang 2001, Amit &…”
BackgroundMethodPhillips, A. G., Ahn, S., & Floresco, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4653-03.2004 · Cited by 230
“…shown that neural activity in the prefrontal cortex (PFC) is positively correlated with the accuracy of behavior guided by working memory (Goldman-Rakic, 1992; Goldman-Rakic, 1995; Pratt and Mizumori, 2001) and that this activity is regulated by DA D 1 receptors (Williams and Goldman-Rakic, 1995).”
InfluentialKrugel, L. K., Biele, G., Mohr, P. N. C., Li, S.-C., & Heekeren, H. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905191106 · Cited by 229
“, fast and intuitive learning from rewards (1, 2)], to complex executive processes that require high capacities of attention and working memory (3, 4).”
BackgroundClatworthy, P. L., Lewis, S. J. G., Brichard, L., Hong, Y. T., Izquierdo, D., Clark, L., Cools, R., Aigbirhio, F. I., Baron, J.-C., Fryer, T. D., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3266-08.2009 · Cited by 229
“Such effects can be explained by different hypothesized “inverted U”-shaped relationships between performance on different tasks and PFC dopamine, at the systems (Williams and Goldman-Rakic, 1995; Mattay et al., 2003; Roberts et al., 1994) or cellular (Vijayraghavan et al.”
BackgroundInfluentialMolecular Targets for Treating Cognitive Dysfunction in Schizophrenia
Gray, J. A., & Roth, B. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm074 · Cited by 227
Changes in behavior-related neuronal activity in the striatum during learning
Schultz, W. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00122-x · Cited by 225
Murphy, B. L., Arnsten, A. F. T., Jentsch, J. D., & Roth, R. H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07768.1996 · Cited by 225
Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia
George, T. P. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00296-2 · Cited by 226
A Neurocomputational Theory of the Dopaminergic Modulation of Working Memory Functions
Durstewitz, D., Kelc, M., & Güntürkün, O. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02807.1999 · Cited by 229
The amphetamine-induced sensitized state as a model of schizophrenia
Featherstone, R. E., Kapur, S., & Fletcher, P. J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.025 · Cited by 233
Floresco, S., & Phillips, A. G. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.934 · Cited by 231
Dopaminergic Modulation of Visual Attention and Working Memory in the Rodent Prefrontal Cortex
Chudasama, Y., & Robbins, T. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300490 · Cited by 234
“D1 agonists including SKF 81297 are typically characterized by an inverted ‘U’-shaped DA function where efficiency of cognitive performance is related to the level of D1 receptor stimulation (Robbins, 1985; Williams and Goldman-Rakic, 1995; Arnsten, 1998; Zahrt et al, 1997).”
BackgroundResultInfluentialCarlson, C. L., Tamm, L., & Gaub, M. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199712000-00019 · Cited by 237
The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity
Bortolozzi, A. A., Díaz-Mataix, L., Scorza, M. C., Celada, P., & Artigas, F. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03485.x · Cited by 230
Hanson, J. L., Chung, M. K., Avants, B. B., Rudolph, K. D., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., & Pollak, S. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0307-12.2012 · Cited by 219
“A large body of research in typically developing individuals, humans who have suffered brain damage, and nonhuman animal research samples has linked executive functions with the PFC (D’Esposito et al., 1995; Williams and Goldman-Rakic, 1995; Dias et al., 1996; Owen et al., 1996).”
Visuo-Spatial Working Memory Span: A Sensitive Measure of Cognitive Deficits in Children With ADHD
Westerberg, H., Hirvikoski, T., Forssberg, H., & Klingberg, T. (2004) · Child Neuropsychology · doi:10.1080/09297040409609806 · Cited by 225
“It is also well known that WM functioning is dependent on dopamine (Williams & Goldman-Rakic, 1995), which is consistent with the association of ADHD with atypical dopaminergic transmission (Cook et al., 1995).”
BackgroundPrefrontal cortex and working memory processes
Funahashi, S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.003 · Cited by 236
“…(Barbas , 1992; Pandya and Barnes, 1987), or modulatory signals by catecholaminergic and monoaminergic inputs (Arnsten, 1998; Luciana et al., 1998; Muly et al., 1998; Sawaguchi and Goldman-Rakic, 1994; Sawaguchi, 1998; Wang et al., 2004; Watanabe et al., 1997; Williams and Goldman-Rakic, 1995).”
Direct and indirect cellular effects of aspartame on the brain
Humphries, P., Pretorius, E., & Naudé, H. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602866 · Cited by 229
“D1-receptors are involved in working memory performance (Williams and Goldman-Rakic (1995)).”
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209
“For DA transmission through D1 receptors, an optimal level of DA activity is required for best working memory performance (Williams and Goldman-Rakic, 1995; Zahrt et al., 1997; Vijayraghavan et al., 2007).”
BackgroundMonte-Silva, K. K., Kuo, M., Thirugnanasambandam, N., Liebetanz, D., Paulus, W., & Nitsche, M. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0728-09.2009 · Cited by 217
“Substantial literature points to an inverted U-shaped relation between cognitive performance and DA or D1 stimulation levels (Williams and Goldman-Rakic, 1995; Verma and Moghaddam, 1996; Zahrt et al., 1997; Muly et al., 1998; Robbins, 2000; Floresco and Phillips, 2001).”
BackgroundD1Receptor in Interneurons of Macaque Prefrontal Cortex: Distribution and Subcellular Localization
Muly, E. C., Szigeti‐Buck, K., & Goldman‐Rakic, P. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10553.1998 · Cited by 220
Self-citationAultman, J. M., & Moghaddam, B. (2000) · Psychopharmacology · doi:10.1007/s002130000590 · Cited by 220
Cahill, L., & McGaugh, J. L. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80078-x · Cited by 301
Honey, G. D., & Bullmore, E. T. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.05.009 · Cited by 214
Nicola, S. M., Kombian, S. B., & Malenka, R. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01591.1996 · Cited by 212
Neonatal Damage of the Ventral Hippocampus Impairs Working Memory in the Rat
Lipska, B. K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00282-8 · Cited by 211
A Neural Circuit Basis for Spatial Working Memory
Constantinidis, C., & Wang, X. (2004) · The Neuroscientist · doi:10.1177/1073858404268742 · Cited by 223
“Similarly, neurons in the inferior temporal cortex can be highly selective for spatial position ( DiCarlo and Maunsell 2003 ).”
BackgroundRegulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors
Pei, L., Lee, F. J. S., Moszczyńska, A., Vukusic, B., & Liu, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3922-03.2004 · Cited by 215
“Many studies have suggested the involvement of dopamine D1-like receptors in the process of working and memory (Sawaguchi and Goldman-Rakic, 1991; Williams and Goldman- Rakic, 1995).”
BackgroundAnimal models of working memory: insights for targeting cognitive dysfunction in schizophrenia
Castner, S. A., Goldman‐Rakic, P. S., & Williams, G. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1710-9 · Cited by 211
“This is an ideal system for the examination of the effects of local and systemic drug action on memory-related neuronal responses (Williams and Goldman-Rakic 1995; Williams et al. 2002a), the strength of inhibitory processes in relation to spatial tuning and trial epoch (Rao et al. 1999, 2000;…”
Self-citationMaternal programming of defensive responses through sustained effects on gene expression
Zhang, T.-Y., Bagot, R., Parent, C., Nesbitt, C., Bredy, T. W., Caldji, C., Fish, E., Anisman, H., Szyf, M., & Meaney, M. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.009 · Cited by 206
Rethinking schizophrenia in the context of normal neurodevelopment
Catts, V. S., Fung, S. J., Long, L. E., Joshi, D., Vercammen, A., Allen, K. M., Fillman, S. G., Rothmond, D. A., Sinclair, D., Tiwari, Y., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00060 · Cited by 206
“…Nieoullon, 2002; Glickstein et al., 2005; Mizoguchi et al., 2009) are impacted in schizophrenia and are sensitive to changes in cortical dopamine (Williams and Goldman-Rakic, 1995; Lewis, 1997; Romanides et al., 1999) As these cognitive functions change across development, it is of interest to…”
BackgroundCognitive enhancement by drugs in health and disease
Husain, M., & Mehta, M. A. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.002 · Cited by 241
Influence of Reward Expectation on Visuospatial Processing in Macaque Lateral Prefrontal Cortex
Kobayashi, S., Lauwereyns, J., Koizumi, M., Sakagami, M., & Hikosaka, O. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00472.2001 · Cited by 206
The cerebral cortex: a case for a common site of action of antipsychotics
Lidow, M. S., Williams, G. V., & Goldman‐Rakic, P. S. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01186-9 · Cited by 201
Self-citationHall, K. T., Lembo, A. J., Kirsch, I., Ziogas, D. C., Douaiher, J., Jensen, K. B., Conboy, L. A., Kelley, J. M., Kokkotou, E. G., & Kaptchuk, T. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048135 · Cited by 212
“The inverted U-shaped dopamine response curve, reported in many COMT functional studies suggests a narrow range for optimum dopamine cortical function [48,49].”
BackgroundPehek, E. A., Nocjar, C., Roth, B. L., Byrd, T. A., & Mabrouk, O. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300819 · Cited by 212
“Therefore, it is likely that an optimal balance of DA tone in the PFC is essential for normal cortical function (Williams and Goldman-Rakic, 1995).”
BackgroundLambe, E. K., Krimer, L. S., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08780.2000 · Cited by 204
Li, Z., Ichikawa, J., Dai, J., & Meltzer, H. Y. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.04.028 · Cited by 203
Cools, R., & Arnsten, A. F. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01100-8 · Cited by 216
Disturbed memory and amnesia related to intensive care
Jones, C., Griffiths, R. D., & Humphris, G. M. (2000) · Memory · doi:10.1080/096582100387632 · Cited by 200
Frontal-striatal circuit functions: Context, sequence, and consequence
Saint‐Cyr, J. A. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617703910125 · Cited by 207
Functional reorganization of brain networks across the human menstrual cycle
Pritschet, L., Santander, T., Taylor, C. M., Layher, E., Yu, S., Miller, M. B., Grafton, S. T., & Jacobs, E. G. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117091 · Cited by 202
Esposito, G., Kirkby, B. S., Horn, J. D. V., Ellmore, T. M., & Berman, K. F. (1999) · Brain · doi:10.1093/brain/122.5.963 · Cited by 202
Dopamine Decreases the Excitability of Layer V Pyramidal Cells in the Rat Prefrontal Cortex
Gulledge, A. T., & Jaffe, D. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-21-09139.1998 · Cited by 201
Alcohol and the prefrontal cortex
Abernathy, K., Chandler, L. J., & Woodward, J. J. (2010) · International Review of Neurobiology · doi:10.1016/s0074-7742(10)91009-x · Cited by 196
COURTNEY, S. M. (2004) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.4.4.501 · Cited by 198
“For example, although work by Goldman-Rakic and her colleagues has demonstrated that both dopamine ( Williams & Goldman-Rakic, 1995 ) and serotonin (Williams, Rao, & Goldman-Rakic, 2002) affect spatial tuning of the cells in the DLPFC that demonstrate sustained activity during delayed response tasks, dopaminergic and…”
ResultTian, Y., Baek, J., Lee, S., & Jang, C. (2010) · Synapse · doi:10.1002/syn.20746 · Cited by 197
“…cortex, a subregion of frontal cortex, can produce distractibility, hyperactivity, and impulsivity (Solanto, 2002), and dopamine and GABA dysregulation here can influence cognitive impairment (Anderson et al., 1999; Goldman-Rakic et al., 2000; Rao et al., 2000; Williams and Goldman-Rakic, 1995).”
BackgroundBari, A., Eagle, D. M., Mar, A. C., Robinson, E. S. J., & Robbins, T. W. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1537-0 · Cited by 194
Mehta, M. A., Manes, F. F., Magnolfi, G., Sahakian, B. J., & Robbins, T. W. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1899-2 · Cited by 198
“…administration of DA D2 agents in monkeys appears to modulate SWM performance (Arnsten et al. 1995), while administration of specific DA D1, but not D2, receptor agents, directly into the PFC modulates performance on similar tasks (Sawaguchi and Goldman-Rakic 1991; Williams and Goldman-Rakic 1995).”
BackgroundSCH 23390: The First Selective Dopamine D1‐Like Receptor Antagonist
Bourne, J. A. (2001) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2001.tb00207.x · Cited by 201
“SCH 23390 by itself had no effect on performance cortex (8,51), demonstrating that supranormal D1 receptor stimulation in the PFC is sufficient to impair PFC working function.”
ResultInfluentialDopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex
Otani, S., Blond, O., Desce, J. M., & Crépel, F. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00677-5 · Cited by 196
FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain
Wang, H., Wu, L.-J., Kim, S. S., Lee, F. J. S., Gong, B., Toyoda, H., Ren, M., Shang, Y.-Z., Xu, H., Liu, F., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.027 · Cited by 186
“DA functions in its target cells through five subtypes of DA receptors (D1–D5) (Huang and Kandel, 1995; West and Grace, 2002; Williams and Goldman-Rakic, 1995).”
BackgroundDopaminergic Modulation of Long-term Synaptic Plasticity in Rat Prefrontal Neurons
Otani, S. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg092 · Cited by 196
“Dopamine plays important roles in the function of primate prefrontal cortex (PFC) (Sawaguchi and Goldman-Rakic, 1991, 1994; Goldman-Rakic, 1995; William and Goldman-Rakic, 1995) and the rodent medial frontal cortex (Glowinski et al., 1984), which is believed by many to be the functional counterpart…”
BackgroundInfluentialDopamine modulation in the basal ganglia locks the gate to working memory
Gruber, A. J., Dayan, P., Gutkin, B. S., & Solla, S. A. (2006) · Journal of Computational Neuroscience · doi:10.1007/s10827-005-5705-x · Cited by 189
Arnsten, A. F. T. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26014-7 · Cited by 198
de Jongh, R., Bolt, I. L. L. E., Schermer, M., & Olivier, B. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.12.001 · Cited by 198
Tan, H. Y., Nicodemus, K. K., Chen, Q., Li, Z., Brooke, J. K., Honea, R. A., Kolachana, B. S., Straub, R. E., Meyer‐Lindenberg, A., Sei, Y., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34725 · Cited by 199
Baldwin, A. E., Sadeghian, K., & Kelley, A. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01063.2002 · Cited by 193
Vittoz, N. M., & Berridge, C. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300807 · Cited by 192
“…under both appetitive and aversive conditions (Sokolowski and Salamone, 1994; Wilkinson et al, 1998; Bassareo and Di Chiara, 1997; Baldwin et al, 2002), working memory (Arnsten et al, 1994; Williams and Goldman-Rakic, 1995; Murphy et al, 1996; Phillips et al, 2004), and attention (Robbins, 2000).”
BackgroundDopaminergic influences on formation of a motor memory
Flöel, A., Breitenstein, C., Hummel, F. C., Celnik, P. A., Gingert, C., Sawaki, L. A., Knecht, S., & Cohen, L. G. (2005) · Annals of Neurology · doi:10.1002/ana.20536 · Cited by 187
Twenty-Five Lessons from Computational Neuromodulation
Dayan, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.027 · Cited by 190
“…a stimulus that predicts future reward or future safety, could directly influence the storage of this stimulus in working memory (Cohen and Servan-Schreiber, 1993; Durstewitz et al., 2000; O’Reilly et al., 2002), via dopamine’s known effects in prefrontal cortex (Williams and Goldman-Rakic, 1995).”
BackgroundXing, B., Li, Y.-C., & Gao, W.-J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.005 · Cited by 196
The primate working memory networks
Constantinidis, C., & Procyk, E. (2004) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.4.4.444 · Cited by 186
“The association of striatal and frontal dopamine input to learning and working memory is well known, and it is related to major prefrontal dysfunction in humans (Castner, Goldman-Rakic, & Williams, 2004; Schultz, 2001; G. V. Williams & Goldman-Rakic, 1995).”
BackgroundSullivan, R. M. (2004) · Stress · doi:10.1080/102538900410001679310 · Cited by 188
“…of DAergic activity in the medial PFC parallel findings noted earlier in a number of attentional and learning/memory paradigms, where too much or too little DA activity impairs the performance of prefrontally-mediated functions (Williams and Goldman-Rakic, 1995; Granon et al., 2000; Robbins, 2000).”
BackgroundResultMoratalla, R., Xu, M., Tonegawa, S., & Graybiel, A. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14928 · Cited by 188
Attention and working memory: a dynamical model of neuronal activity in the prefrontal cortex
Deco, G., & Rolls, E. T. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02956.x · Cited by 189
Parkinson's disease and dopaminergic therapy—differential effects on movement, reward and cognition
Rowe, J. B., Hughes, L. E., Ghosh, B. C. P., Eckstein, D., Williams‐Gray, C. H., Fallon, S. J., Barker, R., & Owen, A. M. (2008) · Brain · doi:10.1093/brain/awn112 · Cited by 196
“Finally, one must consider whether the dopaminergic treatment has a direct effect on the prefrontal BOLD fMRI response because of vasoactive afferents from dopaminergic neurons (Williams and Goldman-Rakic, 1995; Krimer et al., 1998).”
BackgroundGurden, H., Tassin, J., & Jay, T. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00395-4 · Cited by 189
Otani, S., Auclair, N., Desce, J. M., Roisin, M. P., & Crépel, F. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09788.1999 · Cited by 185
The pipeline and future of drug development in schizophrenia
Gray, J. A., & Roth, B. L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002062 · Cited by 182
Puig, M. V., Rose, J., Schmidt, R., & Freund, N. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00093 · Cited by 207
“…extracellular DA in the PFC during WM tasks (Watanabe et al., 1997) that exerts its actions via local D1R (Sawaguchi and Goldman-Rakic, 1991, 1994; Williams and Goldman-Rakic, 1995; Murphy et al., 1996; Collins et al., 1998; Robbins, 2000; Seamans and Yang, 2004; Castner and Williams, 2007;…”
BackgroundDopamine Modulates Episodic Memory Persistence in Old Age
Chowdhury, R., Guitart‐Masip, M., Bunzeck, N., Dolan, R. J., & Düzel, E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1278-12.2012 · Cited by 179
Yang, C. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00112-2 · Cited by 185
Restraint increases dopaminergic burst firing in awake rats
Anstrom, K. K., & Woodward, D. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300730 · Cited by 181
“Although higher cognitive processes have been shown to be dependent on cortical dopamine neurotransmission (Williams and Goldman-Rakic, 1995; Murphy et al, 1996), performance is not linearly related to DA receptor activation.”
BackgroundVisuomotor Areas of the Frontal Lobe
Schall, J. D. (1997) · Cerebral cortex · doi:10.1007/978-1-4757-9625-4_13 · Cited by 185
Williams‐Gray, C. H., Hampshire, A., Robbins, T. W., Owen, A. M., & Barker, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0774-07.2007 · Cited by 181
Spatial learning deficit in dopamine D1 receptor knockout mice
El-Ghundi, M., Fletcher, P. J., Drago, J., Sibley, D. R., O’Dowd, B. F., & George, S. R. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00573-7 · Cited by 173
The “Psychic” Neuron of the Cerebral Cortex
Goldman, P. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11270.x · Cited by 178
Lindefors, N., Barati, S., & O'Connor, W. T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00255-2 · Cited by 178
Dissociable Contributions by Prefrontal D1 and D2 Receptors to Risk-Based Decision Making
Onge, J. R. S., Abhari, H., & Floresco, S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1020-11.2011 · Cited by 186
“Previous studies of this kind have revealed either that D1, but not D2, antagonism disrupts functions such as attention or working memory (Williams and Goldman-Rakic, 1995; Seamans et al., 1998; Granon et al., 2000) or that both receptors act cooperatively to facilitate set-shifting or bias…”
BackgroundInfluentialBraun, U., Harneit, A., Pergola, G., Menara, T., Schäfer, A., Betzel, R. F., Zang, Z., Schweiger, J. I., Zhang, X., Schwarz, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23694-9 · Cited by 198
Role of Dopamine in Learning and Memory
Kulisevsky, J. (2000) · Drugs & Aging · doi:10.2165/00002512-200016050-00006 · Cited by 183
Metadata
- Authors
- Williams, G. V., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- ORCID
- Williams, Graham V.
- Venue
- Nature
- Published
- 1995-08
- Volume
- 376
- Issue
- 6541
- Pages
- 572-575
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2084007108
- Cited by
- 1,593
- References
- 42
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 27 · 2018: 37 · 2017: 33 · 2016: 48 · 2015: 63 · 2014: 45 · 2013: 78 · 2012: 74
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dopamine D1 receptor, working memory, prefrontal cortex, memory field, dopamine D1 receptor antagonist, synaptic modulation, excitatory synaptic input, iontophoresis, single-unit recording
- MeSH terms
- Animals, Haplorhini, Dose-Response Relationship, Drug, Iontophoresis, Memory, Neurons, Psychomotor Performance, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2
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